Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/IPO7_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/IPO7_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/IPO7_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/IPO7_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/IPO7_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/IPO7_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1904030 | Prostate | BPH | negative regulation of cyclin-dependent protein kinase activity | 14/3107 | 33/18723 | 4.08e-04 | 2.97e-03 | 14 |
GO:0045736 | Prostate | BPH | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 13/3107 | 32/18723 | 1.07e-03 | 6.67e-03 | 13 |
GO:00719012 | Prostate | BPH | negative regulation of protein serine/threonine kinase activity | 33/3107 | 120/18723 | 1.76e-03 | 1.01e-02 | 33 |
GO:007259417 | Prostate | Tumor | establishment of protein localization to organelle | 151/3246 | 422/18723 | 3.19e-20 | 2.83e-17 | 151 |
GO:003450414 | Prostate | Tumor | protein localization to nucleus | 100/3246 | 290/18723 | 1.05e-12 | 9.98e-11 | 100 |
GO:000691316 | Prostate | Tumor | nucleocytoplasmic transport | 97/3246 | 301/18723 | 1.78e-10 | 1.05e-08 | 97 |
GO:005116916 | Prostate | Tumor | nuclear transport | 97/3246 | 301/18723 | 1.78e-10 | 1.05e-08 | 97 |
GO:004232618 | Prostate | Tumor | negative regulation of phosphorylation | 112/3246 | 385/18723 | 6.17e-09 | 2.42e-07 | 112 |
GO:004593619 | Prostate | Tumor | negative regulation of phosphate metabolic process | 124/3246 | 441/18723 | 9.08e-09 | 3.44e-07 | 124 |
GO:001056319 | Prostate | Tumor | negative regulation of phosphorus metabolic process | 124/3246 | 442/18723 | 1.05e-08 | 3.88e-07 | 124 |
GO:005134819 | Prostate | Tumor | negative regulation of transferase activity | 81/3246 | 268/18723 | 1.30e-07 | 3.35e-06 | 81 |
GO:001703814 | Prostate | Tumor | protein import | 66/3246 | 206/18723 | 1.78e-07 | 4.38e-06 | 66 |
GO:000193318 | Prostate | Tumor | negative regulation of protein phosphorylation | 97/3246 | 342/18723 | 2.36e-07 | 5.60e-06 | 97 |
GO:007190014 | Prostate | Tumor | regulation of protein serine/threonine kinase activity | 98/3246 | 359/18723 | 1.39e-06 | 2.51e-05 | 98 |
GO:003367316 | Prostate | Tumor | negative regulation of kinase activity | 70/3246 | 237/18723 | 2.27e-06 | 3.87e-05 | 70 |
GO:005117012 | Prostate | Tumor | import into nucleus | 51/3246 | 159/18723 | 4.08e-06 | 6.51e-05 | 51 |
GO:000660611 | Prostate | Tumor | protein import into nucleus | 50/3246 | 155/18723 | 4.22e-06 | 6.67e-05 | 50 |
GO:000646917 | Prostate | Tumor | negative regulation of protein kinase activity | 63/3246 | 212/18723 | 5.73e-06 | 8.78e-05 | 63 |
GO:19040291 | Prostate | Tumor | regulation of cyclin-dependent protein kinase activity | 34/3246 | 98/18723 | 2.60e-05 | 3.18e-04 | 34 |
GO:00000791 | Prostate | Tumor | regulation of cyclin-dependent protein serine/threonine kinase activity | 32/3246 | 94/18723 | 6.75e-05 | 7.21e-04 | 32 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030137 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0301312 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa030132 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa030133 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa030134 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
hsa030135 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IPO7 | SNV | Missense_Mutation | rs773555364 | c.2413N>T | p.Arg805Cys | p.R805C | O95373 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IPO7 | SNV | Missense_Mutation | | c.2403A>T | p.Leu801Phe | p.L801F | O95373 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-D8-A1X8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimicin+cyclophosphamide | SD |
IPO7 | deletion | Frame_Shift_Del | novel | c.788delN | p.Ala264ProfsTer5 | p.A264Pfs*5 | O95373 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
IPO7 | SNV | Missense_Mutation | | c.2248A>G | p.Lys750Glu | p.K750E | O95373 | protein_coding | deleterious(0.01) | possibly_damaging(0.805) | TCGA-EA-A5FO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IPO7 | SNV | Missense_Mutation | | c.1564N>G | p.Gln522Glu | p.Q522E | O95373 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EK-A2R7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IPO7 | SNV | Missense_Mutation | | c.3044G>T | p.Gly1015Val | p.G1015V | O95373 | protein_coding | deleterious(0) | benign(0.156) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IPO7 | SNV | Missense_Mutation | novel | c.21N>G | p.Ile7Met | p.I7M | O95373 | protein_coding | deleterious(0.01) | possibly_damaging(0.681) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IPO7 | SNV | Missense_Mutation | novel | c.2849N>C | p.Asp950Ala | p.D950A | O95373 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
IPO7 | SNV | Missense_Mutation | | c.1976C>T | p.Ala659Val | p.A659V | O95373 | protein_coding | tolerated(1) | benign(0.042) | TCGA-VS-A9V4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
IPO7 | SNV | Missense_Mutation | novel | c.2411N>G | p.Leu804Arg | p.L804R | O95373 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |