GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:003461412 | Liver | HCC | cellular response to reactive oxygen species | 102/7958 | 155/18723 | 3.70e-09 | 9.89e-08 | 102 |
GO:001082112 | Liver | HCC | regulation of mitochondrion organization | 96/7958 | 144/18723 | 3.82e-09 | 1.02e-07 | 96 |
GO:007138322 | Liver | HCC | cellular response to steroid hormone stimulus | 128/7958 | 204/18723 | 3.92e-09 | 1.04e-07 | 128 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:003133312 | Liver | HCC | negative regulation of protein-containing complex assembly | 91/7958 | 141/18723 | 1.01e-07 | 1.98e-06 | 91 |
GO:00517882 | Liver | HCC | response to misfolded protein | 23/7958 | 25/18723 | 2.95e-07 | 5.14e-06 | 23 |
GO:00703011 | Liver | HCC | cellular response to hydrogen peroxide | 66/7958 | 98/18723 | 5.74e-07 | 9.07e-06 | 66 |
GO:190314611 | Liver | HCC | regulation of autophagy of mitochondrion | 28/7958 | 33/18723 | 6.57e-07 | 1.03e-05 | 28 |
GO:006191211 | Liver | HCC | selective autophagy | 49/7958 | 68/18723 | 7.43e-07 | 1.15e-05 | 49 |
GO:007121811 | Liver | HCC | cellular response to misfolded protein | 21/7958 | 23/18723 | 1.39e-06 | 2.01e-05 | 21 |
GO:00080882 | Liver | HCC | axo-dendritic transport | 52/7958 | 75/18723 | 2.34e-06 | 3.14e-05 | 52 |
GO:000651521 | Liver | HCC | protein quality control for misfolded or incompletely synthesized proteins | 24/7958 | 28/18723 | 3.01e-06 | 3.99e-05 | 24 |
GO:004340121 | Liver | HCC | steroid hormone mediated signaling pathway | 84/7958 | 136/18723 | 4.42e-06 | 5.62e-05 | 84 |
GO:003051821 | Liver | HCC | intracellular steroid hormone receptor signaling pathway | 73/7958 | 116/18723 | 7.04e-06 | 8.41e-05 | 73 |
GO:00723843 | Liver | HCC | organelle transport along microtubule | 56/7958 | 85/18723 | 1.13e-05 | 1.29e-04 | 56 |
GO:007050711 | Liver | HCC | regulation of microtubule cytoskeleton organization | 88/7958 | 148/18723 | 2.28e-05 | 2.41e-04 | 88 |
GO:0098780 | Liver | HCC | response to mitochondrial depolarisation | 17/7958 | 19/18723 | 2.93e-05 | 3.03e-04 | 17 |
GO:003314321 | Liver | HCC | regulation of intracellular steroid hormone receptor signaling pathway | 49/7958 | 74/18723 | 3.21e-05 | 3.26e-04 | 49 |
GO:003070521 | Liver | HCC | cytoskeleton-dependent intracellular transport | 111/7958 | 195/18723 | 3.25e-05 | 3.28e-04 | 111 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HDAC6 | MYOFIB | Colorectum | ADJ | OTUD6B-AS1,COL13A1,RNF170, etc. | 3.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HDAC6 | MYOFIB | Colorectum | FAP | OTUD6B-AS1,COL13A1,RNF170, etc. | 2.54e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
HDAC6 | BAS | Endometrium | ADJ | MINDY2,ZNF662,TAF1C, etc. | 6.21e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HDAC6 | iATC | Thyroid | Healthy | MRPL36,NSRP1,MVB12A, etc. | 6.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC6 | SNV | Missense_Mutation | novel | c.3579G>C | p.Gln1193His | p.Q1193H | Q9UBN7 | protein_coding | deleterious(0) | possibly_damaging(0.722) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
HDAC6 | SNV | Missense_Mutation | | c.2601N>A | p.Met867Ile | p.M867I | Q9UBN7 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HDAC6 | SNV | Missense_Mutation | rs782451640 | c.2609G>A | p.Arg870Gln | p.R870Q | Q9UBN7 | protein_coding | tolerated(0.48) | benign(0.033) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.1699N>T | p.Asp567Tyr | p.D567Y | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD |
HDAC6 | SNV | Missense_Mutation | | c.379C>G | p.Arg127Gly | p.R127G | Q9UBN7 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
HDAC6 | SNV | Missense_Mutation | | c.2518N>C | p.Glu840Gln | p.E840Q | Q9UBN7 | protein_coding | deleterious(0.03) | benign(0.113) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | | c.846N>T | p.Arg282Ser | p.R282S | Q9UBN7 | protein_coding | tolerated(0.77) | benign(0.038) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
HDAC6 | SNV | Missense_Mutation | novel | c.208N>A | p.Gly70Arg | p.G70R | Q9UBN7 | protein_coding | deleterious(0.03) | benign(0.294) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
HDAC6 | SNV | Missense_Mutation | rs781974625 | c.3181N>A | p.Glu1061Lys | p.E1061K | Q9UBN7 | protein_coding | tolerated(0.35) | benign(0) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC6 | SNV | Missense_Mutation | rs782618133 | c.2021N>G | p.Tyr674Cys | p.Y674C | Q9UBN7 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID28092474-Compound-32i | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-28 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-9 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID29671355-Compound-14 | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PRACINOSTAT | PRACINOSTAT | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | PMID28092474-Compound-33p | | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | | BELINOSTAT | BELINOSTAT | 25937017 |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 187051807 | SCRIPTAID | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 187051792 | PANOBINOSTAT | |
10013 | HDAC6 | ENZYME, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, DRUGGABLE GENOME | inhibitor | 249565599 | | |