Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GABARAP_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/GABARAP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GABARAP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/GABARAP_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GABARAP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/GABARAP_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GABARAP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GABARAP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GABARAP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GABARAP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190336425 | Cervix | N_HPV | positive regulation of cellular protein catabolic process | 15/534 | 155/18723 | 3.84e-05 | 9.41e-04 | 15 |
GO:007149624 | Cervix | N_HPV | cellular response to external stimulus | 23/534 | 320/18723 | 5.03e-05 | 1.15e-03 | 23 |
GO:003166724 | Cervix | N_HPV | response to nutrient levels | 29/534 | 474/18723 | 1.04e-04 | 2.08e-03 | 29 |
GO:004573225 | Cervix | N_HPV | positive regulation of protein catabolic process | 18/534 | 231/18723 | 1.19e-04 | 2.31e-03 | 18 |
GO:190305025 | Cervix | N_HPV | regulation of proteolysis involved in cellular protein catabolic process | 17/534 | 221/18723 | 2.13e-04 | 3.55e-03 | 17 |
GO:003166815 | Cervix | N_HPV | cellular response to extracellular stimulus | 18/534 | 246/18723 | 2.60e-04 | 4.13e-03 | 18 |
GO:006113625 | Cervix | N_HPV | regulation of proteasomal protein catabolic process | 15/534 | 187/18723 | 3.15e-04 | 4.75e-03 | 15 |
GO:000989615 | Cervix | N_HPV | positive regulation of catabolic process | 28/534 | 492/18723 | 4.43e-04 | 6.10e-03 | 28 |
GO:009719124 | Cervix | N_HPV | extrinsic apoptotic signaling pathway | 16/534 | 219/18723 | 5.71e-04 | 7.61e-03 | 16 |
GO:003133115 | Cervix | N_HPV | positive regulation of cellular catabolic process | 25/534 | 427/18723 | 5.88e-04 | 7.74e-03 | 25 |
GO:000660515 | Cervix | N_HPV | protein targeting | 20/534 | 314/18723 | 7.30e-04 | 9.21e-03 | 20 |
GO:001049815 | Cervix | N_HPV | proteasomal protein catabolic process | 27/534 | 490/18723 | 9.06e-04 | 1.08e-02 | 27 |
GO:003243615 | Cervix | N_HPV | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 9/534 | 90/18723 | 1.06e-03 | 1.23e-02 | 9 |
GO:003166915 | Cervix | N_HPV | cellular response to nutrient levels | 15/534 | 215/18723 | 1.34e-03 | 1.45e-02 | 15 |
GO:190305214 | Cervix | N_HPV | positive regulation of proteolysis involved in cellular protein catabolic process | 11/534 | 133/18723 | 1.51e-03 | 1.58e-02 | 11 |
GO:190180015 | Cervix | N_HPV | positive regulation of proteasomal protein catabolic process | 10/534 | 114/18723 | 1.57e-03 | 1.63e-02 | 10 |
GO:003243425 | Cervix | N_HPV | regulation of proteasomal ubiquitin-dependent protein catabolic process | 11/534 | 134/18723 | 1.60e-03 | 1.66e-02 | 11 |
GO:200005825 | Cervix | N_HPV | regulation of ubiquitin-dependent protein catabolic process | 12/534 | 164/18723 | 2.66e-03 | 2.35e-02 | 12 |
GO:200006015 | Cervix | N_HPV | positive regulation of ubiquitin-dependent protein catabolic process | 9/534 | 107/18723 | 3.53e-03 | 2.84e-02 | 9 |
GO:004259413 | Cervix | N_HPV | response to starvation | 13/534 | 197/18723 | 4.39e-03 | 3.33e-02 | 13 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GABARAP | SNV | Missense_Mutation | | c.80N>G | p.Asp27Gly | p.D27G | O95166 | protein_coding | deleterious(0.02) | benign(0.043) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GABARAP | SNV | Missense_Mutation | | c.217N>A | p.Glu73Lys | p.E73K | O95166 | protein_coding | deleterious(0.01) | benign(0.369) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GABARAP | SNV | Missense_Mutation | novel | c.269N>T | p.Thr90Ile | p.T90I | O95166 | protein_coding | tolerated(0.35) | benign(0.158) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GABARAP | SNV | Missense_Mutation | novel | c.60N>T | p.Lys20Asn | p.K20N | O95166 | protein_coding | tolerated(0.08) | benign(0.214) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABARAP | SNV | Missense_Mutation | novel | c.69N>T | p.Lys23Asn | p.K23N | O95166 | protein_coding | tolerated(0.17) | benign(0.017) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABARAP | SNV | Missense_Mutation | | c.300N>C | p.Glu100Asp | p.E100D | O95166 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABARAP | SNV | Missense_Mutation | rs781270795 | c.303A>C | p.Glu101Asp | p.E101D | O95166 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GABARAP | SNV | Missense_Mutation | novel | c.271A>C | p.Met91Leu | p.M91L | O95166 | protein_coding | tolerated(0.07) | benign(0.05) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GABARAP | SNV | Missense_Mutation | novel | c.122T>C | p.Ile41Thr | p.I41T | O95166 | protein_coding | deleterious(0.01) | benign(0.267) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |