Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FSD2

Gene summary for FSD2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FSD2

Gene ID

123722

Gene namefibronectin type III and SPRY domain containing 2
Gene AliasSPRYD1
Cytomap15q25.2
Gene Typeprotein-coding
GO ID

GO:0005575

UniProtAcc

A1L4K1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
123722FSD2HCC1HumanLiverHCC6.31e-221.60e+000.5336
123722FSD2HCC2HumanLiverHCC6.04e-302.02e+000.5341
123722FSD2HCC5HumanLiverHCC4.49e-231.51e+000.4932
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001097523ThyroidATCregulation of neuron projection development212/6293445/187234.16e-101.14e-08212
GO:003133035ThyroidATCnegative regulation of cellular catabolic process136/6293262/187236.47e-101.71e-08136
GO:000989529ThyroidATCnegative regulation of catabolic process159/6293320/187231.61e-093.99e-08159
GO:003166927ThyroidATCcellular response to nutrient levels112/6293215/187231.57e-083.20e-07112
GO:003166827ThyroidATCcellular response to extracellular stimulus125/6293246/187231.65e-083.31e-07125
GO:004259424ThyroidATCresponse to starvation103/6293197/187234.59e-088.31e-07103
GO:000926724ThyroidATCcellular response to starvation85/6293156/187236.14e-081.09e-0685
GO:0031667210ThyroidATCresponse to nutrient levels212/6293474/187232.37e-073.70e-06212
GO:0016358110ThyroidATCdendrite development119/6293243/187234.65e-076.75e-06119
GO:003090015ThyroidATCforebrain development164/6293379/187234.85e-053.87e-04164
GO:002153712ThyroidATCtelencephalon development113/6293248/187235.61e-054.32e-04113
GO:002154312ThyroidATCpallium development81/6293169/187237.67e-055.80e-0481
GO:003563322ThyroidATCmaintenance of blood-brain barrier22/629335/187233.74e-042.28e-0322
GO:003526414ThyroidATCmulticellular organism growth61/6293132/187231.73e-038.66e-0361
GO:004505621ThyroidATCtranscytosis14/629321/187231.99e-039.54e-0314
GO:003030719ThyroidATCpositive regulation of cell growth74/6293166/187232.06e-039.73e-0374
GO:004863815ThyroidATCregulation of developmental growth136/6293330/187232.17e-031.02e-02136
GO:000657522ThyroidATCcellular modified amino acid metabolic process82/6293188/187232.60e-031.20e-0282
GO:0021766ThyroidATChippocampus development38/629380/187236.84e-032.72e-0238
GO:004592720ThyroidATCpositive regulation of growth106/6293259/187237.90e-033.06e-02106
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FSD2SNVMissense_Mutationrs200109394c.1411N>Tp.Pro471Serp.P471SA1L4K1protein_codingdeleterious(0.04)probably_damaging(1)TCGA-A7-A26E-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanSD
FSD2SNVMissense_Mutationc.413N>Tp.Gly138Valp.G138VA1L4K1protein_codingdeleterious(0.04)benign(0.348)TCGA-AN-A0AM-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
FSD2SNVMissense_Mutationrs774888742c.1499N>Tp.Ser500Leup.S500LA1L4K1protein_codingdeleterious(0)probably_damaging(0.998)TCGA-D8-A142-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamidSD
FSD2SNVMissense_Mutationc.923C>Ap.Thr308Lysp.T308KA1L4K1protein_codingdeleterious(0.01)benign(0.435)TCGA-D8-A1X9-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyadriamycin+cyclophosphamideSD
FSD2SNVMissense_Mutationrs781225191c.388G>Ap.Glu130Lysp.E130KA1L4K1protein_codingtolerated(0.07)benign(0.096)TCGA-DS-A0VK-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
FSD2SNVMissense_Mutationnovelc.493N>Tp.Val165Phep.V165FA1L4K1protein_codingdeleterious(0)probably_damaging(0.957)TCGA-DS-A1OC-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapygemcitabineSD
FSD2SNVMissense_Mutationc.520N>Ap.Glu174Lysp.E174KA1L4K1protein_codingtolerated(0.07)possibly_damaging(0.867)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
FSD2SNVMissense_Mutationc.1398G>Ap.Met466Ilep.M466IA1L4K1protein_codingtolerated(0.05)benign(0.003)TCGA-LP-A4AV-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
FSD2SNVMissense_Mutationc.88G>Ap.Glu30Lysp.E30KA1L4K1protein_codingtolerated(0.41)benign(0.006)TCGA-VS-A8QC-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapypaclitaxelPD
FSD2SNVMissense_Mutationnovelc.586N>Ap.Glu196Lysp.E196KA1L4K1protein_codingdeleterious(0.04)benign(0.157)TCGA-ZJ-AAXU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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