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Gene: FADD |
Gene summary for FADD |
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Gene information | Species | Human | Gene symbol | FADD | Gene ID | 8772 |
Gene name | Fas associated via death domain | |
Gene Alias | GIG3 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | Q13158 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8772 | FADD | LZE4T | Human | Esophagus | ESCC | 3.08e-18 | 5.80e-01 | 0.0811 |
8772 | FADD | LZE5T | Human | Esophagus | ESCC | 9.93e-08 | 5.04e-01 | 0.0514 |
8772 | FADD | LZE8T | Human | Esophagus | ESCC | 8.22e-06 | 1.76e-01 | 0.067 |
8772 | FADD | LZE20T | Human | Esophagus | ESCC | 1.47e-17 | 6.62e-01 | 0.0662 |
8772 | FADD | LZE21D1 | Human | Esophagus | HGIN | 1.77e-03 | 6.20e-01 | 0.0632 |
8772 | FADD | LZE22T | Human | Esophagus | ESCC | 6.33e-08 | 9.59e-01 | 0.068 |
8772 | FADD | LZE24T | Human | Esophagus | ESCC | 9.82e-10 | 2.66e-01 | 0.0596 |
8772 | FADD | LZE21T | Human | Esophagus | ESCC | 1.08e-11 | 1.22e+00 | 0.0655 |
8772 | FADD | P1T-E | Human | Esophagus | ESCC | 1.45e-24 | 1.11e+00 | 0.0875 |
8772 | FADD | P2T-E | Human | Esophagus | ESCC | 2.36e-108 | 2.14e+00 | 0.1177 |
8772 | FADD | P4T-E | Human | Esophagus | ESCC | 3.61e-21 | 5.62e-01 | 0.1323 |
8772 | FADD | P5T-E | Human | Esophagus | ESCC | 2.72e-27 | 5.36e-01 | 0.1327 |
8772 | FADD | P8T-E | Human | Esophagus | ESCC | 8.52e-76 | 1.47e+00 | 0.0889 |
8772 | FADD | P9T-E | Human | Esophagus | ESCC | 7.29e-13 | 2.63e-01 | 0.1131 |
8772 | FADD | P10T-E | Human | Esophagus | ESCC | 3.41e-09 | 1.55e-01 | 0.116 |
8772 | FADD | P11T-E | Human | Esophagus | ESCC | 6.07e-09 | 4.33e-01 | 0.1426 |
8772 | FADD | P12T-E | Human | Esophagus | ESCC | 6.68e-33 | 3.20e-01 | 0.1122 |
8772 | FADD | P15T-E | Human | Esophagus | ESCC | 6.18e-25 | 6.75e-01 | 0.1149 |
8772 | FADD | P16T-E | Human | Esophagus | ESCC | 1.77e-90 | 1.80e+00 | 0.1153 |
8772 | FADD | P17T-E | Human | Esophagus | ESCC | 5.79e-24 | 1.84e+00 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00712601 | Liver | HCC | cellular response to mechanical stimulus | 48/7958 | 81/18723 | 1.72e-03 | 8.96e-03 | 48 |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
GO:0060338 | Liver | HCC | regulation of type I interferon-mediated signaling pathway | 24/7958 | 36/18723 | 2.95e-03 | 1.38e-02 | 24 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00450881 | Liver | HCC | regulation of innate immune response | 113/7958 | 218/18723 | 3.27e-03 | 1.50e-02 | 113 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:200105612 | Liver | HCC | positive regulation of cysteine-type endopeptidase activity | 79/7958 | 148/18723 | 4.82e-03 | 2.03e-02 | 79 |
GO:00432791 | Liver | HCC | response to alkaloid | 62/7958 | 115/18723 | 8.79e-03 | 3.42e-02 | 62 |
GO:200123320 | Oral cavity | OSCC | regulation of apoptotic signaling pathway | 242/7305 | 356/18723 | 6.66e-29 | 3.24e-26 | 242 |
GO:004586220 | Oral cavity | OSCC | positive regulation of proteolysis | 236/7305 | 372/18723 | 6.53e-22 | 1.38e-19 | 236 |
GO:200011620 | Oral cavity | OSCC | regulation of cysteine-type endopeptidase activity | 152/7305 | 235/18723 | 1.14e-15 | 8.13e-14 | 152 |
GO:009719120 | Oral cavity | OSCC | extrinsic apoptotic signaling pathway | 142/7305 | 219/18723 | 7.34e-15 | 4.55e-13 | 142 |
GO:200123510 | Oral cavity | OSCC | positive regulation of apoptotic signaling pathway | 92/7305 | 126/18723 | 8.45e-15 | 5.19e-13 | 92 |
GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
GO:004312218 | Oral cavity | OSCC | regulation of I-kappaB kinase/NF-kappaB signaling | 155/7305 | 249/18723 | 7.79e-14 | 4.14e-12 | 155 |
GO:004312310 | Oral cavity | OSCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 122/7305 | 186/18723 | 1.68e-13 | 8.52e-12 | 122 |
GO:000724910 | Oral cavity | OSCC | I-kappaB kinase/NF-kappaB signaling | 169/7305 | 281/18723 | 4.69e-13 | 2.25e-11 | 169 |
GO:005254720 | Oral cavity | OSCC | regulation of peptidase activity | 255/7305 | 461/18723 | 5.78e-13 | 2.75e-11 | 255 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502230 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
hsa0501030 | Esophagus | HGIN | Alzheimer disease | 130/1383 | 384/8465 | 5.26e-18 | 1.71e-16 | 1.36e-16 | 130 |
hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa0513039 | Esophagus | HGIN | Pathogenic Escherichia coli infection | 54/1383 | 197/8465 | 4.91e-05 | 6.15e-04 | 4.89e-04 | 54 |
hsa0516930 | Esophagus | HGIN | Epstein-Barr virus infection | 55/1383 | 202/8465 | 5.13e-05 | 6.19e-04 | 4.92e-04 | 55 |
hsa0516730 | Esophagus | HGIN | Kaposi sarcoma-associated herpesvirus infection | 51/1383 | 194/8465 | 2.46e-04 | 2.69e-03 | 2.14e-03 | 51 |
hsa0421020 | Esophagus | HGIN | Apoptosis | 36/1383 | 136/8465 | 1.67e-03 | 1.52e-02 | 1.20e-02 | 36 |
hsa0517029 | Esophagus | HGIN | Human immunodeficiency virus 1 infection | 51/1383 | 212/8465 | 2.16e-03 | 1.90e-02 | 1.51e-02 | 51 |
hsa046219 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa0465726 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa0516330 | Esophagus | HGIN | Human cytomegalovirus infection | 51/1383 | 225/8465 | 7.67e-03 | 4.63e-02 | 3.68e-02 | 51 |
hsa05022113 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
hsa05010113 | Esophagus | HGIN | Alzheimer disease | 130/1383 | 384/8465 | 5.26e-18 | 1.71e-16 | 1.36e-16 | 130 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05130115 | Esophagus | HGIN | Pathogenic Escherichia coli infection | 54/1383 | 197/8465 | 4.91e-05 | 6.15e-04 | 4.89e-04 | 54 |
hsa05169114 | Esophagus | HGIN | Epstein-Barr virus infection | 55/1383 | 202/8465 | 5.13e-05 | 6.19e-04 | 4.92e-04 | 55 |
hsa05167114 | Esophagus | HGIN | Kaposi sarcoma-associated herpesvirus infection | 51/1383 | 194/8465 | 2.46e-04 | 2.69e-03 | 2.14e-03 | 51 |
hsa04210110 | Esophagus | HGIN | Apoptosis | 36/1383 | 136/8465 | 1.67e-03 | 1.52e-02 | 1.20e-02 | 36 |
hsa05170112 | Esophagus | HGIN | Human immunodeficiency virus 1 infection | 51/1383 | 212/8465 | 2.16e-03 | 1.90e-02 | 1.51e-02 | 51 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FADD | deletion | Frame_Shift_Del | novel | c.464delA | p.Asn155ThrfsTer16 | p.N155Tfs*16 | Q13158 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FADD | SNV | Missense_Mutation | novel | c.163C>A | p.Leu55Met | p.L55M | Q13158 | protein_coding | tolerated(0.06) | probably_damaging(0.995) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | novel | c.404G>A | p.Arg135His | p.R135H | Q13158 | protein_coding | tolerated(0.44) | benign(0.203) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FADD | SNV | Missense_Mutation | novel | c.485N>C | p.Val162Ala | p.V162A | Q13158 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FADD | SNV | Missense_Mutation | novel | c.525C>A | p.Asp175Glu | p.D175E | Q13158 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | c.331N>C | p.Asp111His | p.D111H | Q13158 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FADD | insertion | Frame_Shift_Ins | novel | c.524_525insG | p.Asp175GlufsTer11 | p.D175Efs*11 | Q13158 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FADD | SNV | Missense_Mutation | novel | c.14N>C | p.Leu5Pro | p.L5P | Q13158 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | novel | c.404N>A | p.Arg135His | p.R135H | Q13158 | protein_coding | tolerated(0.44) | benign(0.203) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FADD | SNV | Missense_Mutation | novel | c.80N>A | p.Cys27Tyr | p.C27Y | Q13158 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8772 | FADD | NA | FAS LIGAND | 11384965 |
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