|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: EVL |
Gene summary for EVL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | EVL | Gene ID | 51466 |
| Gene name | Enah/Vasp-like | |
| Gene Alias | RNB6 | |
| Cytomap | 14q32.2 | |
| Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | A0A024R6K5 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51466 | EVL | GSM4909293 | Human | Breast | IDC | 2.67e-07 | 2.40e-01 | 0.1581 |
| 51466 | EVL | GSM4909296 | Human | Breast | IDC | 2.10e-02 | 2.13e-01 | 0.1524 |
| 51466 | EVL | GSM4909297 | Human | Breast | IDC | 8.52e-16 | 5.53e-01 | 0.1517 |
| 51466 | EVL | GSM4909301 | Human | Breast | IDC | 1.36e-09 | 4.02e-01 | 0.1577 |
| 51466 | EVL | GSM4909302 | Human | Breast | IDC | 2.60e-49 | 1.03e+00 | 0.1545 |
| 51466 | EVL | GSM4909303 | Human | Breast | IDC | 7.33e-07 | 5.84e-01 | 0.0438 |
| 51466 | EVL | GSM4909304 | Human | Breast | IDC | 1.40e-05 | 2.75e-01 | 0.1636 |
| 51466 | EVL | GSM4909305 | Human | Breast | IDC | 5.52e-09 | 4.66e-01 | 0.0436 |
| 51466 | EVL | GSM4909306 | Human | Breast | IDC | 3.04e-30 | 7.26e-01 | 0.1564 |
| 51466 | EVL | GSM4909307 | Human | Breast | IDC | 3.22e-27 | 7.02e-01 | 0.1569 |
| 51466 | EVL | GSM4909308 | Human | Breast | IDC | 2.91e-64 | 9.90e-01 | 0.158 |
| 51466 | EVL | GSM4909311 | Human | Breast | IDC | 2.94e-20 | 3.87e-01 | 0.1534 |
| 51466 | EVL | GSM4909312 | Human | Breast | IDC | 5.78e-12 | 4.68e-01 | 0.1552 |
| 51466 | EVL | GSM4909313 | Human | Breast | IDC | 2.81e-09 | 4.70e-01 | 0.0391 |
| 51466 | EVL | GSM4909317 | Human | Breast | IDC | 4.98e-19 | 5.45e-01 | 0.1355 |
| 51466 | EVL | GSM4909319 | Human | Breast | IDC | 7.22e-11 | -1.35e-01 | 0.1563 |
| 51466 | EVL | GSM4909321 | Human | Breast | IDC | 9.44e-30 | 7.76e-01 | 0.1559 |
| 51466 | EVL | M1 | Human | Breast | IDC | 2.97e-32 | 8.20e-01 | 0.1577 |
| 51466 | EVL | M5 | Human | Breast | IDC | 2.79e-12 | 9.47e-01 | 0.1598 |
| 51466 | EVL | NCCBC2 | Human | Breast | DCIS | 1.75e-12 | 8.57e-01 | 0.1554 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00512622 | Oral cavity | OSCC | protein tetramerization | 48/7305 | 87/18723 | 1.60e-03 | 7.62e-03 | 48 |
| GO:003223119 | Oral cavity | OSCC | regulation of actin filament bundle assembly | 56/7305 | 105/18723 | 1.99e-03 | 9.23e-03 | 56 |
| GO:19000276 | Oral cavity | OSCC | regulation of ruffle assembly | 20/7305 | 31/18723 | 3.57e-03 | 1.49e-02 | 20 |
| GO:001063218 | Oral cavity | OSCC | regulation of epithelial cell migration | 136/7305 | 292/18723 | 4.82e-03 | 1.92e-02 | 136 |
| GO:00514969 | Oral cavity | OSCC | positive regulation of stress fiber assembly | 30/7305 | 52/18723 | 4.84e-03 | 1.92e-02 | 30 |
| GO:005149220 | Oral cavity | OSCC | regulation of stress fiber assembly | 48/7305 | 91/18723 | 5.32e-03 | 2.07e-02 | 48 |
| GO:00313458 | Oral cavity | OSCC | negative regulation of cell projection organization | 89/7305 | 186/18723 | 8.51e-03 | 3.09e-02 | 89 |
| GO:003103217 | Oral cavity | OSCC | actomyosin structure organization | 93/7305 | 196/18723 | 9.63e-03 | 3.41e-02 | 93 |
| GO:011002020 | Oral cavity | OSCC | regulation of actomyosin structure organization | 51/7305 | 100/18723 | 9.74e-03 | 3.45e-02 | 51 |
| GO:00450107 | Oral cavity | OSCC | actin nucleation | 29/7305 | 52/18723 | 1.05e-02 | 3.57e-02 | 29 |
| GO:190290334 | Oral cavity | NEOLP | regulation of supramolecular fiber organization | 88/2005 | 383/18723 | 2.44e-12 | 4.83e-10 | 88 |
| GO:004325432 | Oral cavity | NEOLP | regulation of protein-containing complex assembly | 95/2005 | 428/18723 | 2.76e-12 | 5.29e-10 | 95 |
| GO:000701534 | Oral cavity | NEOLP | actin filament organization | 94/2005 | 442/18723 | 4.49e-11 | 5.80e-09 | 94 |
| GO:003297033 | Oral cavity | NEOLP | regulation of actin filament-based process | 85/2005 | 397/18723 | 2.70e-10 | 2.51e-08 | 85 |
| GO:000166725 | Oral cavity | NEOLP | ameboidal-type cell migration | 96/2005 | 475/18723 | 5.16e-10 | 4.14e-08 | 96 |
| GO:003133433 | Oral cavity | NEOLP | positive regulation of protein-containing complex assembly | 58/2005 | 237/18723 | 1.09e-09 | 7.92e-08 | 58 |
| GO:001063123 | Oral cavity | NEOLP | epithelial cell migration | 77/2005 | 357/18723 | 1.32e-09 | 9.43e-08 | 77 |
| GO:190290533 | Oral cavity | NEOLP | positive regulation of supramolecular fiber organization | 53/2005 | 209/18723 | 1.47e-09 | 1.01e-07 | 53 |
| GO:003295633 | Oral cavity | NEOLP | regulation of actin cytoskeleton organization | 77/2005 | 358/18723 | 1.51e-09 | 1.02e-07 | 77 |
| GO:003227133 | Oral cavity | NEOLP | regulation of protein polymerization | 57/2005 | 233/18723 | 1.54e-09 | 1.03e-07 | 57 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0401518 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
| hsa0401519 | Oral cavity | OSCC | Rap1 signaling pathway | 107/3704 | 210/8465 | 2.01e-02 | 4.34e-02 | 2.21e-02 | 107 |
| hsa0401524 | Oral cavity | NEOLP | Rap1 signaling pathway | 40/1112 | 210/8465 | 9.07e-03 | 3.17e-02 | 1.99e-02 | 40 |
| hsa0401534 | Oral cavity | NEOLP | Rap1 signaling pathway | 40/1112 | 210/8465 | 9.07e-03 | 3.17e-02 | 1.99e-02 | 40 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| EVL | SNV | Missense_Mutation | novel | c.1090T>C | p.Ser364Pro | p.S364P | Q9UI08 | protein_coding | deleterious(0.03) | benign(0.405) | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
| EVL | SNV | Missense_Mutation | novel | c.444N>T | p.Gln148His | p.Q148H | Q9UI08 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| EVL | insertion | In_Frame_Ins | novel | c.899_900insCACCAGACGGGGCCTAGACAA | p.Met300delinsIleThrArgArgGlyLeuAspLys | p.M300delinsITRRGLDK | Q9UI08 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| EVL | insertion | In_Frame_Ins | novel | c.1093_1094insACTCCTCAGGTGAGA | p.Ser364_Arg365insAsnSerSerGlyGlu | p.S364_R365insNSSGE | Q9UI08 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| EVL | SNV | Missense_Mutation | c.1075N>G | p.Gln359Glu | p.Q359E | Q9UI08 | protein_coding | tolerated(0.64) | possibly_damaging(0.83) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
| EVL | SNV | Missense_Mutation | novel | c.1065N>C | p.Lys355Asn | p.K355N | Q9UI08 | protein_coding | tolerated(0.15) | probably_damaging(0.985) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| EVL | SNV | Missense_Mutation | novel | c.409G>C | p.Asp137His | p.D137H | Q9UI08 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| EVL | SNV | Missense_Mutation | novel | c.1090T>C | p.Ser364Pro | p.S364P | Q9UI08 | protein_coding | deleterious(0.03) | benign(0.405) | TCGA-A6-6648-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
| EVL | SNV | Missense_Mutation | novel | c.251G>T | p.Arg84Leu | p.R84L | Q9UI08 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| EVL | SNV | Missense_Mutation | rs750787699 | c.452N>A | p.Arg151His | p.R151H | Q9UI08 | protein_coding | deleterious(0.02) | benign(0.037) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |