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Gene: EIF4H |
Gene summary for EIF4H |
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Gene information | Species | Human | Gene symbol | EIF4H | Gene ID | 7458 |
Gene name | eukaryotic translation initiation factor 4H | |
Gene Alias | WBSCR1 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q15056 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7458 | EIF4H | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.24e-11 | 5.90e-01 | -0.1808 |
7458 | EIF4H | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.85e-09 | 5.98e-01 | -0.0811 |
7458 | EIF4H | HTA11_78_2000001011 | Human | Colorectum | AD | 5.14e-14 | 6.67e-01 | -0.1088 |
7458 | EIF4H | HTA11_347_2000001011 | Human | Colorectum | AD | 4.24e-22 | 6.62e-01 | -0.1954 |
7458 | EIF4H | HTA11_411_2000001011 | Human | Colorectum | SER | 7.11e-07 | 7.72e-01 | -0.2602 |
7458 | EIF4H | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.11e-03 | 4.17e-01 | -0.1207 |
7458 | EIF4H | HTA11_83_2000001011 | Human | Colorectum | SER | 6.15e-07 | 4.35e-01 | -0.1526 |
7458 | EIF4H | HTA11_696_2000001011 | Human | Colorectum | AD | 4.53e-15 | 5.85e-01 | -0.1464 |
7458 | EIF4H | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.15e-13 | 7.34e-01 | -0.059 |
7458 | EIF4H | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.18e-07 | 6.70e-01 | -0.2061 |
7458 | EIF4H | HTA11_866_3004761011 | Human | Colorectum | AD | 6.32e-11 | 5.24e-01 | 0.096 |
7458 | EIF4H | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.91e-06 | 5.97e-01 | 0.0446 |
7458 | EIF4H | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.29e-03 | 5.51e-01 | 0.0528 |
7458 | EIF4H | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.56e-05 | 6.79e-01 | -0.0177 |
7458 | EIF4H | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.27e-12 | 1.06e+00 | 0.0171 |
7458 | EIF4H | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.11e-08 | 5.09e-01 | 0.0674 |
7458 | EIF4H | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.22e-32 | 9.78e-01 | 0.294 |
7458 | EIF4H | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.15e-05 | 1.30e+00 | 0.3487 |
7458 | EIF4H | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.76e-22 | 1.05e+00 | 0.281 |
7458 | EIF4H | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.42e-15 | 7.18e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002183112 | Thyroid | PTC | cytoplasmic translational initiation | 27/5968 | 34/18723 | 1.57e-08 | 3.69e-07 | 27 |
GO:000173117 | Thyroid | PTC | formation of translation preinitiation complex | 9/5968 | 11/18723 | 9.49e-04 | 5.70e-03 | 9 |
GO:0002181210 | Thyroid | goiters | cytoplasmic translation | 73/497 | 148/18723 | 1.65e-75 | 6.83e-72 | 73 |
GO:0022613210 | Thyroid | goiters | ribonucleoprotein complex biogenesis | 47/497 | 463/18723 | 2.79e-15 | 8.90e-13 | 47 |
GO:0022618210 | Thyroid | goiters | ribonucleoprotein complex assembly | 26/497 | 220/18723 | 1.99e-10 | 2.85e-08 | 26 |
GO:0071826210 | Thyroid | goiters | ribonucleoprotein complex subunit organization | 26/497 | 227/18723 | 3.98e-10 | 5.50e-08 | 26 |
GO:0006417210 | Thyroid | goiters | regulation of translation | 35/497 | 468/18723 | 3.94e-08 | 3.71e-06 | 35 |
GO:000641328 | Thyroid | goiters | translational initiation | 16/497 | 118/18723 | 9.22e-08 | 7.64e-06 | 16 |
GO:000644625 | Thyroid | goiters | regulation of translational initiation | 12/497 | 79/18723 | 1.09e-06 | 6.20e-05 | 12 |
GO:000218327 | Thyroid | goiters | cytoplasmic translational initiation | 6/497 | 34/18723 | 2.43e-04 | 6.65e-03 | 6 |
GO:000173121 | Thyroid | goiters | formation of translation preinitiation complex | 3/497 | 11/18723 | 2.62e-03 | 4.17e-02 | 3 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:000218135 | Thyroid | ATC | cytoplasmic translation | 121/6293 | 148/18723 | 1.41e-33 | 1.49e-30 | 121 |
GO:000641334 | Thyroid | ATC | translational initiation | 83/6293 | 118/18723 | 3.44e-16 | 2.88e-14 | 83 |
GO:007182635 | Thyroid | ATC | ribonucleoprotein complex subunit organization | 133/6293 | 227/18723 | 8.32e-15 | 5.01e-13 | 133 |
GO:002261835 | Thyroid | ATC | ribonucleoprotein complex assembly | 129/6293 | 220/18723 | 1.93e-14 | 1.10e-12 | 129 |
GO:000641735 | Thyroid | ATC | regulation of translation | 236/6293 | 468/18723 | 2.39e-14 | 1.34e-12 | 236 |
GO:000644632 | Thyroid | ATC | regulation of translational initiation | 55/6293 | 79/18723 | 6.38e-11 | 2.06e-09 | 55 |
GO:000218334 | Thyroid | ATC | cytoplasmic translational initiation | 27/6293 | 34/18723 | 5.57e-08 | 1.00e-06 | 27 |
GO:000173131 | Thyroid | ATC | formation of translation preinitiation complex | 9/6293 | 11/18723 | 1.46e-03 | 7.47e-03 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF4H | SNV | Missense_Mutation | c.307N>T | p.Gly103Cys | p.G103C | Q15056 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF4H | deletion | In_Frame_Del | novel | c.3_5delNNN | p.Ala2del | p.A2del | Q15056 | protein_coding | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | ||
EIF4H | SNV | Missense_Mutation | novel | c.211C>T | p.Arg71Trp | p.R71W | Q15056 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | novel | c.25G>C | p.Asp9His | p.D9H | Q15056 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.839) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | c.232N>G | p.Thr78Ala | p.T78A | Q15056 | protein_coding | deleterious(0) | possibly_damaging(0.711) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
EIF4H | SNV | Missense_Mutation | novel | c.212N>A | p.Arg71Gln | p.R71Q | Q15056 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CM-4750-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
EIF4H | SNV | Missense_Mutation | c.164A>G | p.Gln55Arg | p.Q55R | Q15056 | protein_coding | deleterious(0.05) | possibly_damaging(0.656) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF4H | SNV | Missense_Mutation | novel | c.647G>A | p.Arg216Gln | p.R216Q | Q15056 | protein_coding | deleterious(0) | benign(0.441) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | novel | c.467C>A | p.Ser156Tyr | p.S156Y | Q15056 | protein_coding | deleterious(0.02) | possibly_damaging(0.601) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | novel | c.92N>A | p.Arg31His | p.R31H | Q15056 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7458 | EIF4H | DRUGGABLE GENOME | GNF-PF-4618 | CHEMBL585964 |
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