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Gene: DCPS |
Gene summary for DCPS |
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Gene information | Species | Human | Gene symbol | DCPS | Gene ID | 28960 |
Gene name | decapping enzyme, scavenger | |
Gene Alias | ARS | |
Cytomap | 11q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | Q96C86 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28960 | DCPS | LZE4T | Human | Esophagus | ESCC | 6.70e-09 | 1.57e-01 | 0.0811 |
28960 | DCPS | LZE7T | Human | Esophagus | ESCC | 3.68e-05 | 2.55e-01 | 0.0667 |
28960 | DCPS | LZE20T | Human | Esophagus | ESCC | 2.06e-06 | 2.66e-01 | 0.0662 |
28960 | DCPS | LZE24T | Human | Esophagus | ESCC | 2.15e-22 | 4.44e-01 | 0.0596 |
28960 | DCPS | P2T-E | Human | Esophagus | ESCC | 4.86e-26 | 5.46e-01 | 0.1177 |
28960 | DCPS | P4T-E | Human | Esophagus | ESCC | 1.52e-49 | 1.03e+00 | 0.1323 |
28960 | DCPS | P5T-E | Human | Esophagus | ESCC | 1.42e-19 | 3.77e-01 | 0.1327 |
28960 | DCPS | P8T-E | Human | Esophagus | ESCC | 1.04e-14 | 2.99e-01 | 0.0889 |
28960 | DCPS | P9T-E | Human | Esophagus | ESCC | 1.77e-16 | 4.01e-01 | 0.1131 |
28960 | DCPS | P10T-E | Human | Esophagus | ESCC | 2.04e-26 | 4.59e-01 | 0.116 |
28960 | DCPS | P11T-E | Human | Esophagus | ESCC | 1.13e-18 | 5.73e-01 | 0.1426 |
28960 | DCPS | P12T-E | Human | Esophagus | ESCC | 2.45e-36 | 5.40e-01 | 0.1122 |
28960 | DCPS | P15T-E | Human | Esophagus | ESCC | 4.35e-17 | 3.79e-01 | 0.1149 |
28960 | DCPS | P16T-E | Human | Esophagus | ESCC | 1.62e-54 | 9.96e-01 | 0.1153 |
28960 | DCPS | P17T-E | Human | Esophagus | ESCC | 1.01e-09 | 3.97e-01 | 0.1278 |
28960 | DCPS | P19T-E | Human | Esophagus | ESCC | 6.29e-12 | 7.67e-01 | 0.1662 |
28960 | DCPS | P20T-E | Human | Esophagus | ESCC | 1.57e-09 | 1.81e-01 | 0.1124 |
28960 | DCPS | P21T-E | Human | Esophagus | ESCC | 3.14e-51 | 9.03e-01 | 0.1617 |
28960 | DCPS | P22T-E | Human | Esophagus | ESCC | 1.56e-13 | 2.76e-01 | 0.1236 |
28960 | DCPS | P23T-E | Human | Esophagus | ESCC | 4.11e-13 | 2.78e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00002912 | Oral cavity | OSCC | nuclear-transcribed mRNA catabolic process, exonucleolytic | 19/7305 | 19/18723 | 1.69e-08 | 3.36e-07 | 19 |
GO:190165419 | Oral cavity | OSCC | response to ketone | 114/7305 | 194/18723 | 1.82e-08 | 3.60e-07 | 114 |
GO:00610149 | Oral cavity | OSCC | positive regulation of mRNA catabolic process | 58/7305 | 87/18723 | 1.59e-07 | 2.61e-06 | 58 |
GO:003166918 | Oral cavity | OSCC | cellular response to nutrient levels | 121/7305 | 215/18723 | 1.96e-07 | 3.17e-06 | 121 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00611579 | Oral cavity | OSCC | mRNA destabilization | 55/7305 | 84/18723 | 8.05e-07 | 1.12e-05 | 55 |
GO:00507799 | Oral cavity | OSCC | RNA destabilization | 57/7305 | 88/18723 | 8.70e-07 | 1.19e-05 | 57 |
GO:00439282 | Oral cavity | OSCC | exonucleolytic catabolism of deadenylated mRNA | 13/7305 | 13/18723 | 4.82e-06 | 5.48e-05 | 13 |
GO:00075849 | Oral cavity | OSCC | response to nutrient | 95/7305 | 174/18723 | 2.09e-05 | 1.99e-04 | 95 |
GO:00905032 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis, exonucleolytic | 29/7305 | 42/18723 | 7.73e-05 | 6.00e-04 | 29 |
GO:19016555 | Oral cavity | OSCC | cellular response to ketone | 56/7305 | 96/18723 | 9.61e-05 | 7.25e-04 | 56 |
GO:00002889 | Oral cavity | OSCC | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 36/7305 | 56/18723 | 1.12e-04 | 8.24e-04 | 36 |
GO:00342495 | Oral cavity | OSCC | negative regulation of cellular amide metabolic process | 130/7305 | 273/18723 | 2.20e-03 | 1.00e-02 | 130 |
GO:00332733 | Oral cavity | OSCC | response to vitamin | 50/7305 | 93/18723 | 2.71e-03 | 1.18e-02 | 50 |
GO:00171485 | Oral cavity | OSCC | negative regulation of translation | 113/7305 | 245/18723 | 1.34e-02 | 4.45e-02 | 113 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:190331119 | Oral cavity | LP | regulation of mRNA metabolic process | 129/4623 | 288/18723 | 5.70e-14 | 6.10e-12 | 129 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa03018 | Liver | Cirrhotic | RNA degradation | 44/2530 | 79/8465 | 1.43e-06 | 1.65e-05 | 1.02e-05 | 44 |
hsa030181 | Liver | Cirrhotic | RNA degradation | 44/2530 | 79/8465 | 1.43e-06 | 1.65e-05 | 1.02e-05 | 44 |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301823 | Oral cavity | LP | RNA degradation | 39/2418 | 79/8465 | 6.98e-05 | 4.38e-04 | 2.83e-04 | 39 |
hsa0301833 | Oral cavity | LP | RNA degradation | 39/2418 | 79/8465 | 6.98e-05 | 4.38e-04 | 2.83e-04 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCPS | SNV | Missense_Mutation | c.419N>C | p.Leu140Pro | p.L140P | Q96C86 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DCPS | SNV | Missense_Mutation | novel | c.184N>T | p.Ile62Phe | p.I62F | Q96C86 | protein_coding | deleterious(0) | benign(0.229) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD |
DCPS | deletion | Frame_Shift_Del | novel | c.677delG | p.Gly226AlafsTer33 | p.G226Afs*33 | Q96C86 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
DCPS | SNV | Missense_Mutation | c.122G>A | p.Arg41His | p.R41H | Q96C86 | protein_coding | tolerated(0.36) | benign(0) | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
DCPS | SNV | Missense_Mutation | rs554435261 | c.658N>A | p.Ala220Thr | p.A220T | Q96C86 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DCPS | SNV | Missense_Mutation | rs773359297 | c.434G>A | p.Arg145His | p.R145H | Q96C86 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DCPS | SNV | Missense_Mutation | rs371676072 | c.958N>A | p.Ala320Thr | p.A320T | Q96C86 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DCPS | SNV | Missense_Mutation | novel | c.350N>G | p.His117Arg | p.H117R | Q96C86 | protein_coding | tolerated(0.68) | benign(0) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DCPS | SNV | Missense_Mutation | rs768453817 | c.694N>A | p.Asp232Asn | p.D232N | Q96C86 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCPS | SNV | Missense_Mutation | c.235N>T | p.Asp79Tyr | p.D79Y | Q96C86 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
28960 | DCPS | ENZYME, DRUGGABLE GENOME | RG3039 | |||
28960 | DCPS | ENZYME, DRUGGABLE GENOME | RG3039 |
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