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Gene: CYRIB |
Gene summary for CYRIB |
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Gene information | Species | Human | Gene symbol | CYRIB | Gene ID | 51571 |
Gene name | CYFIP related Rac1 interactor B | |
Gene Alias | BM-009 | |
Cytomap | 8q24.21 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | A0A024R9G4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51571 | CYRIB | CA_HPV_1 | Human | Cervix | CC | 2.84e-03 | 1.84e-01 | 0.0264 |
51571 | CYRIB | N_HPV_2 | Human | Cervix | N_HPV | 3.16e-03 | 1.85e-01 | -0.0131 |
51571 | CYRIB | CCI_1 | Human | Cervix | CC | 1.93e-06 | -5.20e-01 | 0.528 |
51571 | CYRIB | CCI_2 | Human | Cervix | CC | 8.18e-06 | -5.20e-01 | 0.5249 |
51571 | CYRIB | CCI_3 | Human | Cervix | CC | 5.72e-09 | -5.20e-01 | 0.516 |
51571 | CYRIB | CCII_1 | Human | Cervix | CC | 7.66e-13 | -5.20e-01 | 0.3249 |
51571 | CYRIB | Tumor | Human | Cervix | CC | 6.17e-26 | -5.20e-01 | 0.1241 |
51571 | CYRIB | sample1 | Human | Cervix | CC | 1.45e-10 | -5.20e-01 | 0.0959 |
51571 | CYRIB | sample3 | Human | Cervix | CC | 2.98e-28 | -5.20e-01 | 0.1387 |
51571 | CYRIB | H2 | Human | Cervix | HSIL_HPV | 2.98e-28 | -5.20e-01 | 0.0632 |
51571 | CYRIB | L1 | Human | Cervix | CC | 3.46e-14 | -5.20e-01 | 0.0802 |
51571 | CYRIB | T1 | Human | Cervix | CC | 5.04e-24 | -5.20e-01 | 0.0918 |
51571 | CYRIB | T2 | Human | Cervix | CC | 1.97e-05 | -5.20e-01 | 0.0709 |
51571 | CYRIB | T3 | Human | Cervix | CC | 4.34e-27 | -5.20e-01 | 0.1389 |
51571 | CYRIB | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.85e-17 | 3.24e-01 | 0.0155 |
51571 | CYRIB | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.28e-26 | 6.02e-01 | -0.1808 |
51571 | CYRIB | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.22e-05 | 3.08e-01 | 0.0216 |
51571 | CYRIB | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.66e-36 | 8.32e-01 | -0.0811 |
51571 | CYRIB | HTA11_78_2000001011 | Human | Colorectum | AD | 2.21e-33 | 8.00e-01 | -0.1088 |
51571 | CYRIB | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-53 | 8.72e-01 | -0.1954 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002705 | Cervix | N_HPV | positive regulation of leukocyte mediated immunity | 13/534 | 134/18723 | 1.21e-04 | 2.33e-03 | 13 |
GO:0002824 | Cervix | N_HPV | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 11/534 | 107/18723 | 2.40e-04 | 3.86e-03 | 11 |
GO:004325425 | Cervix | N_HPV | regulation of protein-containing complex assembly | 26/534 | 428/18723 | 2.62e-04 | 4.15e-03 | 26 |
GO:190290423 | Cervix | N_HPV | negative regulation of supramolecular fiber organization | 14/534 | 167/18723 | 3.16e-04 | 4.75e-03 | 14 |
GO:0002706 | Cervix | N_HPV | regulation of lymphocyte mediated immunity | 14/534 | 168/18723 | 3.36e-04 | 5.00e-03 | 14 |
GO:00028211 | Cervix | N_HPV | positive regulation of adaptive immune response | 11/534 | 112/18723 | 3.58e-04 | 5.26e-03 | 11 |
GO:00326091 | Cervix | N_HPV | interferon-gamma production | 11/534 | 112/18723 | 3.58e-04 | 5.26e-03 | 11 |
GO:00326491 | Cervix | N_HPV | regulation of interferon-gamma production | 11/534 | 112/18723 | 3.58e-04 | 5.26e-03 | 11 |
GO:0002708 | Cervix | N_HPV | positive regulation of lymphocyte mediated immunity | 11/534 | 113/18723 | 3.87e-04 | 5.54e-03 | 11 |
GO:00026992 | Cervix | N_HPV | positive regulation of immune effector process | 17/534 | 235/18723 | 4.36e-04 | 6.01e-03 | 17 |
GO:003295625 | Cervix | N_HPV | regulation of actin cytoskeleton organization | 22/534 | 358/18723 | 6.55e-04 | 8.42e-03 | 22 |
GO:005125824 | Cervix | N_HPV | protein polymerization | 19/534 | 297/18723 | 9.32e-04 | 1.11e-02 | 19 |
GO:00019123 | Cervix | N_HPV | positive regulation of leukocyte mediated cytotoxicity | 7/534 | 56/18723 | 1.02e-03 | 1.20e-02 | 7 |
GO:001063914 | Cervix | N_HPV | negative regulation of organelle organization | 21/534 | 348/18723 | 1.08e-03 | 1.25e-02 | 21 |
GO:007121912 | Cervix | N_HPV | cellular response to molecule of bacterial origin | 15/534 | 221/18723 | 1.76e-03 | 1.78e-02 | 15 |
GO:007121622 | Cervix | N_HPV | cellular response to biotic stimulus | 16/534 | 246/18723 | 1.94e-03 | 1.91e-02 | 16 |
GO:003227213 | Cervix | N_HPV | negative regulation of protein polymerization | 8/534 | 80/18723 | 1.99e-03 | 1.95e-02 | 8 |
GO:00313432 | Cervix | N_HPV | positive regulation of cell killing | 7/534 | 63/18723 | 2.05e-03 | 1.98e-02 | 7 |
GO:00019102 | Cervix | N_HPV | regulation of leukocyte mediated cytotoxicity | 8/534 | 82/18723 | 2.33e-03 | 2.15e-02 | 8 |
GO:00308378 | Cervix | N_HPV | negative regulation of actin filament polymerization | 7/534 | 65/18723 | 2.46e-03 | 2.22e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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