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Gene: CNOT3 |
Gene summary for CNOT3 |
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Gene information | Species | Human | Gene symbol | CNOT3 | Gene ID | 4849 |
Gene name | CCR4-NOT transcription complex subunit 3 | |
Gene Alias | IDDSADF | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | A0A024R4R3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4849 | CNOT3 | LZE4T | Human | Esophagus | ESCC | 4.39e-07 | 2.24e-01 | 0.0811 |
4849 | CNOT3 | LZE7T | Human | Esophagus | ESCC | 5.79e-07 | 3.07e-01 | 0.0667 |
4849 | CNOT3 | LZE8T | Human | Esophagus | ESCC | 3.39e-04 | 1.84e-01 | 0.067 |
4849 | CNOT3 | LZE20T | Human | Esophagus | ESCC | 5.69e-05 | 1.80e-01 | 0.0662 |
4849 | CNOT3 | LZE22T | Human | Esophagus | ESCC | 8.60e-08 | 4.62e-01 | 0.068 |
4849 | CNOT3 | LZE24T | Human | Esophagus | ESCC | 3.34e-22 | 4.62e-01 | 0.0596 |
4849 | CNOT3 | LZE22D3 | Human | Esophagus | HGIN | 8.52e-03 | 4.13e-01 | 0.0653 |
4849 | CNOT3 | P1T-E | Human | Esophagus | ESCC | 1.70e-11 | 4.20e-01 | 0.0875 |
4849 | CNOT3 | P2T-E | Human | Esophagus | ESCC | 1.01e-25 | 3.49e-01 | 0.1177 |
4849 | CNOT3 | P4T-E | Human | Esophagus | ESCC | 8.14e-16 | 3.70e-01 | 0.1323 |
4849 | CNOT3 | P5T-E | Human | Esophagus | ESCC | 1.44e-05 | 1.63e-01 | 0.1327 |
4849 | CNOT3 | P8T-E | Human | Esophagus | ESCC | 5.58e-47 | 8.04e-01 | 0.0889 |
4849 | CNOT3 | P9T-E | Human | Esophagus | ESCC | 7.26e-09 | 2.06e-01 | 0.1131 |
4849 | CNOT3 | P10T-E | Human | Esophagus | ESCC | 2.24e-32 | 5.43e-01 | 0.116 |
4849 | CNOT3 | P11T-E | Human | Esophagus | ESCC | 2.24e-11 | 4.00e-01 | 0.1426 |
4849 | CNOT3 | P12T-E | Human | Esophagus | ESCC | 2.29e-23 | 4.65e-01 | 0.1122 |
4849 | CNOT3 | P15T-E | Human | Esophagus | ESCC | 5.17e-37 | 6.74e-01 | 0.1149 |
4849 | CNOT3 | P16T-E | Human | Esophagus | ESCC | 5.34e-17 | 3.06e-01 | 0.1153 |
4849 | CNOT3 | P17T-E | Human | Esophagus | ESCC | 3.57e-11 | 4.42e-01 | 0.1278 |
4849 | CNOT3 | P19T-E | Human | Esophagus | ESCC | 3.14e-03 | 3.48e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005077918 | Skin | cSCC | RNA destabilization | 44/4864 | 88/18723 | 1.16e-06 | 2.03e-05 | 44 |
GO:001982715 | Skin | cSCC | stem cell population maintenance | 58/4864 | 131/18723 | 4.20e-06 | 6.24e-05 | 58 |
GO:003424915 | Skin | cSCC | negative regulation of cellular amide metabolic process | 104/4864 | 273/18723 | 6.44e-06 | 9.00e-05 | 104 |
GO:009872715 | Skin | cSCC | maintenance of cell number | 58/4864 | 134/18723 | 9.83e-06 | 1.29e-04 | 58 |
GO:001714814 | Skin | cSCC | negative regulation of translation | 93/4864 | 245/18723 | 2.28e-05 | 2.63e-04 | 93 |
GO:000028818 | Skin | cSCC | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 29/4864 | 56/18723 | 3.25e-05 | 3.56e-04 | 29 |
GO:000182512 | Skin | cSCC | blastocyst formation | 21/4864 | 38/18723 | 1.17e-04 | 1.08e-03 | 21 |
GO:000182912 | Skin | cSCC | trophectodermal cell differentiation | 11/4864 | 17/18723 | 8.85e-04 | 6.07e-03 | 11 |
GO:000028917 | Skin | cSCC | nuclear-transcribed mRNA poly(A) tail shortening | 14/4864 | 29/18723 | 8.08e-03 | 3.74e-02 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301810 | Esophagus | HGIN | RNA degradation | 27/1383 | 79/8465 | 7.73e-05 | 9.00e-04 | 7.15e-04 | 27 |
hsa0301815 | Esophagus | HGIN | RNA degradation | 27/1383 | 79/8465 | 7.73e-05 | 9.00e-04 | 7.15e-04 | 27 |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNOT3 | SNV | Missense_Mutation | c.853N>C | p.Asp285His | p.D285H | O75175 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-A7-A13F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CNOT3 | SNV | Missense_Mutation | rs745641513 | c.1699N>A | p.Glu567Lys | p.E567K | O75175 | protein_coding | tolerated(0.13) | benign(0.105) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
CNOT3 | SNV | Missense_Mutation | c.645N>T | p.Gln215His | p.Q215H | O75175 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CNOT3 | SNV | Missense_Mutation | c.1711N>G | p.Ile571Val | p.I571V | O75175 | protein_coding | tolerated(0.67) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CNOT3 | SNV | Missense_Mutation | c.124N>A | p.Glu42Lys | p.E42K | O75175 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CNOT3 | SNV | Missense_Mutation | c.2208N>T | p.Lys736Asn | p.K736N | O75175 | protein_coding | deleterious(0) | benign(0.23) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CNOT3 | SNV | Missense_Mutation | c.88C>G | p.Gln30Glu | p.Q30E | O75175 | protein_coding | tolerated(0.21) | benign(0.253) | TCGA-E9-A1NE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
CNOT3 | insertion | Frame_Shift_Ins | rs753475896 | c.732dupC | p.Ser245GlnfsTer8 | p.S245Qfs*8 | O75175 | protein_coding | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CNOT3 | insertion | Frame_Shift_Ins | novel | c.1670_1671insCTTTGAGCAGCAGTGGGGGCAACAATGCCAGCAGCCAGGCCTT | p.Glu557AspfsTer88 | p.E557Dfs*88 | O75175 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
CNOT3 | insertion | Frame_Shift_Ins | rs753475896 | c.732dupC | p.Ser245GlnfsTer8 | p.S245Qfs*8 | O75175 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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