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Gene: CITED2 |
Gene summary for CITED2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CITED2 | Gene ID | 10370 |
| Gene name | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | |
| Gene Alias | ASD8 | |
| Cytomap | 6q24.1 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | D9ZGF1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10370 | CITED2 | LZE7T | Human | Esophagus | ESCC | 1.86e-04 | -5.27e-02 | 0.0667 |
| 10370 | CITED2 | LZE8T | Human | Esophagus | ESCC | 1.68e-02 | -2.10e-01 | 0.067 |
| 10370 | CITED2 | LZE24T | Human | Esophagus | ESCC | 5.29e-10 | 1.09e+00 | 0.0596 |
| 10370 | CITED2 | LZE21T | Human | Esophagus | ESCC | 1.55e-03 | 7.30e-01 | 0.0655 |
| 10370 | CITED2 | P1T-E | Human | Esophagus | ESCC | 3.36e-12 | 1.34e+00 | 0.0875 |
| 10370 | CITED2 | P2T-E | Human | Esophagus | ESCC | 5.02e-23 | 5.22e-01 | 0.1177 |
| 10370 | CITED2 | P4T-E | Human | Esophagus | ESCC | 7.34e-14 | 7.64e-01 | 0.1323 |
| 10370 | CITED2 | P5T-E | Human | Esophagus | ESCC | 5.43e-42 | 1.42e+00 | 0.1327 |
| 10370 | CITED2 | P8T-E | Human | Esophagus | ESCC | 2.89e-24 | 7.21e-01 | 0.0889 |
| 10370 | CITED2 | P9T-E | Human | Esophagus | ESCC | 1.09e-02 | 4.32e-01 | 0.1131 |
| 10370 | CITED2 | P10T-E | Human | Esophagus | ESCC | 8.94e-27 | 5.41e-01 | 0.116 |
| 10370 | CITED2 | P11T-E | Human | Esophagus | ESCC | 1.14e-24 | 1.89e+00 | 0.1426 |
| 10370 | CITED2 | P12T-E | Human | Esophagus | ESCC | 1.67e-07 | 3.99e-01 | 0.1122 |
| 10370 | CITED2 | P15T-E | Human | Esophagus | ESCC | 1.09e-37 | 1.45e+00 | 0.1149 |
| 10370 | CITED2 | P16T-E | Human | Esophagus | ESCC | 3.99e-23 | 6.50e-01 | 0.1153 |
| 10370 | CITED2 | P17T-E | Human | Esophagus | ESCC | 1.91e-03 | 8.57e-01 | 0.1278 |
| 10370 | CITED2 | P19T-E | Human | Esophagus | ESCC | 6.24e-04 | 9.82e-01 | 0.1662 |
| 10370 | CITED2 | P20T-E | Human | Esophagus | ESCC | 2.05e-14 | 7.33e-01 | 0.1124 |
| 10370 | CITED2 | P21T-E | Human | Esophagus | ESCC | 6.31e-09 | 1.35e-01 | 0.1617 |
| 10370 | CITED2 | P22T-E | Human | Esophagus | ESCC | 2.55e-04 | 2.11e-01 | 0.1236 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00018433 | Liver | HCC | neural tube closure | 53/7958 | 88/18723 | 5.95e-04 | 3.75e-03 | 53 |
| GO:00972016 | Liver | HCC | negative regulation of transcription from RNA polymerase II promoter in response to stress | 11/7958 | 12/18723 | 5.97e-04 | 3.75e-03 | 11 |
| GO:00140204 | Liver | HCC | primary neural tube formation | 56/7958 | 94/18723 | 6.19e-04 | 3.86e-03 | 56 |
| GO:00305111 | Liver | HCC | positive regulation of transforming growth factor beta receptor signaling pathway | 23/7958 | 32/18723 | 7.37e-04 | 4.47e-03 | 23 |
| GO:19038461 | Liver | HCC | positive regulation of cellular response to transforming growth factor beta stimulus | 23/7958 | 32/18723 | 7.37e-04 | 4.47e-03 | 23 |
| GO:007145611 | Liver | HCC | cellular response to hypoxia | 84/7958 | 151/18723 | 7.57e-04 | 4.56e-03 | 84 |
| GO:00606063 | Liver | HCC | tube closure | 53/7958 | 89/18723 | 8.67e-04 | 5.14e-03 | 53 |
| GO:000717921 | Liver | HCC | transforming growth factor beta receptor signaling pathway | 106/7958 | 198/18723 | 1.09e-03 | 6.23e-03 | 106 |
| GO:00459263 | Liver | HCC | negative regulation of growth | 129/7958 | 249/18723 | 1.81e-03 | 9.37e-03 | 129 |
| GO:00075691 | Liver | HCC | cell aging | 73/7958 | 132/18723 | 2.00e-03 | 1.01e-02 | 73 |
| GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
| GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
| GO:19038442 | Liver | HCC | regulation of cellular response to transforming growth factor beta stimulus | 72/7958 | 131/18723 | 2.65e-03 | 1.27e-02 | 72 |
| GO:00219154 | Liver | HCC | neural tube development | 82/7958 | 152/18723 | 2.83e-03 | 1.33e-02 | 82 |
| GO:00436271 | Liver | HCC | response to estrogen | 44/7958 | 75/18723 | 3.44e-03 | 1.55e-02 | 44 |
| GO:001701511 | Liver | HCC | regulation of transforming growth factor beta receptor signaling pathway | 70/7958 | 128/18723 | 3.56e-03 | 1.59e-02 | 70 |
| GO:00601351 | Liver | HCC | maternal process involved in female pregnancy | 37/7958 | 62/18723 | 4.73e-03 | 2.02e-02 | 37 |
| GO:00018384 | Liver | HCC | embryonic epithelial tube formation | 66/7958 | 121/18723 | 4.94e-03 | 2.07e-02 | 66 |
| GO:00075651 | Liver | HCC | female pregnancy | 99/7958 | 193/18723 | 8.24e-03 | 3.23e-02 | 99 |
| GO:00721754 | Liver | HCC | epithelial tube formation | 70/7958 | 132/18723 | 9.29e-03 | 3.57e-02 | 70 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04137210 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
| hsa0413738 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
| hsa0413721 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
| hsa0413731 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
| hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
| hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
| hsa0413728 | Oral cavity | OSCC | Mitophagy - animal | 58/3704 | 72/8465 | 1.48e-10 | 2.07e-09 | 1.05e-09 | 58 |
| hsa04137112 | Oral cavity | OSCC | Mitophagy - animal | 58/3704 | 72/8465 | 1.48e-10 | 2.07e-09 | 1.05e-09 | 58 |
| hsa0413729 | Oral cavity | LP | Mitophagy - animal | 38/2418 | 72/8465 | 1.24e-05 | 8.63e-05 | 5.57e-05 | 38 |
| hsa0413737 | Oral cavity | LP | Mitophagy - animal | 38/2418 | 72/8465 | 1.24e-05 | 8.63e-05 | 5.57e-05 | 38 |
| hsa0413726 | Prostate | BPH | Mitophagy - animal | 28/1718 | 72/8465 | 2.12e-04 | 1.13e-03 | 6.98e-04 | 28 |
| hsa04137111 | Prostate | BPH | Mitophagy - animal | 28/1718 | 72/8465 | 2.12e-04 | 1.13e-03 | 6.98e-04 | 28 |
| hsa0413727 | Prostate | Tumor | Mitophagy - animal | 30/1791 | 72/8465 | 6.31e-05 | 4.64e-04 | 2.88e-04 | 30 |
| hsa0413736 | Prostate | Tumor | Mitophagy - animal | 30/1791 | 72/8465 | 6.31e-05 | 4.64e-04 | 2.88e-04 | 30 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CITED2 | SNV | Missense_Mutation | novel | c.775G>A | p.Asp259Asn | p.D259N | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| CITED2 | SNV | Missense_Mutation | novel | c.235G>T | p.Gly79Trp | p.G79W | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BH-A8FY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CITED2 | SNV | Missense_Mutation | novel | c.8G>T | p.Gly3Val | p.G3V | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.98) | TCGA-OL-A5RZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
| CITED2 | SNV | Missense_Mutation | c.697C>A | p.Leu233Ile | p.L233I | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| CITED2 | SNV | Missense_Mutation | rs762473911 | c.202N>G | p.Met68Val | p.M68V | protein_coding | tolerated(0.15) | benign(0.015) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| CITED2 | SNV | Missense_Mutation | novel | c.669N>G | p.Ile223Met | p.I223M | protein_coding | tolerated(0.52) | benign(0.047) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| CITED2 | SNV | Missense_Mutation | novel | c.278C>T | p.Ala93Val | p.A93V | protein_coding | tolerated(0.28) | benign(0.328) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
| CITED2 | SNV | Missense_Mutation | novel | c.389N>T | p.Asn130Ile | p.N130I | protein_coding | deleterious(0.01) | benign(0.277) | TCGA-AX-A3G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
| CITED2 | SNV | Missense_Mutation | rs780995434 | c.505A>G | p.Ser169Gly | p.S169G | protein_coding | tolerated(0.41) | benign(0) | TCGA-B5-A11G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CITED2 | SNV | Missense_Mutation | novel | c.310N>G | p.Met104Val | p.M104V | protein_coding | tolerated(0.11) | benign(0.11) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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