Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CCDC186_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CCDC186_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CCDC186_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CCDC186_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CCDC186_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000974632 | Thyroid | ATC | response to hexose | 95/6293 | 219/18723 | 1.56e-03 | 7.92e-03 | 95 |
GO:000974932 | Thyroid | ATC | response to glucose | 92/6293 | 212/18723 | 1.80e-03 | 8.87e-03 | 92 |
GO:007169223 | Thyroid | ATC | protein localization to extracellular region | 150/6293 | 368/18723 | 2.25e-03 | 1.05e-02 | 150 |
GO:003350024 | Thyroid | ATC | carbohydrate homeostasis | 109/6293 | 259/18723 | 2.56e-03 | 1.18e-02 | 109 |
GO:000930623 | Thyroid | ATC | protein secretion | 146/6293 | 359/18723 | 2.83e-03 | 1.29e-02 | 146 |
GO:007132224 | Thyroid | ATC | cellular response to carbohydrate stimulus | 72/6293 | 163/18723 | 3.12e-03 | 1.41e-02 | 72 |
GO:003559223 | Thyroid | ATC | establishment of protein localization to extracellular region | 146/6293 | 360/18723 | 3.20e-03 | 1.44e-02 | 146 |
GO:004259325 | Thyroid | ATC | glucose homeostasis | 108/6293 | 258/18723 | 3.27e-03 | 1.47e-02 | 108 |
GO:000167825 | Thyroid | ATC | cellular glucose homeostasis | 75/6293 | 172/18723 | 3.89e-03 | 1.69e-02 | 75 |
GO:007133324 | Thyroid | ATC | cellular response to glucose stimulus | 66/6293 | 151/18723 | 6.05e-03 | 2.43e-02 | 66 |
GO:009951813 | Thyroid | ATC | vesicle cytoskeletal trafficking | 35/6293 | 73/18723 | 7.71e-03 | 3.00e-02 | 35 |
GO:007133124 | Thyroid | ATC | cellular response to hexose stimulus | 66/6293 | 153/18723 | 8.61e-03 | 3.28e-02 | 66 |
GO:007132624 | Thyroid | ATC | cellular response to monosaccharide stimulus | 66/6293 | 154/18723 | 1.02e-02 | 3.71e-02 | 66 |
GO:003577313 | Thyroid | ATC | insulin secretion involved in cellular response to glucose stimulus | 34/6293 | 73/18723 | 1.45e-02 | 4.98e-02 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC186 | SNV | Missense_Mutation | | c.775N>C | p.Glu259Gln | p.E259Q | Q7Z3E2 | protein_coding | tolerated(0.11) | probably_damaging(0.997) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC186 | SNV | Missense_Mutation | rs758664195 | c.1943N>A | p.Arg648Gln | p.R648Q | Q7Z3E2 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC186 | SNV | Missense_Mutation | rs757447418 | c.1292N>A | p.Arg431Gln | p.R431Q | Q7Z3E2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC186 | SNV | Missense_Mutation | novel | c.999N>T | p.Glu333Asp | p.E333D | Q7Z3E2 | protein_coding | tolerated(0.05) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC186 | SNV | Missense_Mutation | novel | c.2191N>T | p.Asn731Tyr | p.N731Y | Q7Z3E2 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC186 | insertion | Nonsense_Mutation | novel | c.1758_1759insTAATACAAATATATTCAGATATTTGCCATAGAGTTTAGTTTGTTTTTA | p.Ser586_Glu587insTer | p.S586_E587ins* | Q7Z3E2 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
CCDC186 | SNV | Missense_Mutation | rs759611860 | c.829G>A | p.Val277Ile | p.V277I | Q7Z3E2 | protein_coding | tolerated(0.32) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCDC186 | SNV | Missense_Mutation | | c.583N>C | p.Glu195Gln | p.E195Q | Q7Z3E2 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.714) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CCDC186 | SNV | Missense_Mutation | | c.1522C>G | p.Leu508Val | p.L508V | Q7Z3E2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCDC186 | SNV | Missense_Mutation | novel | c.410C>T | p.Ser137Leu | p.S137L | Q7Z3E2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.133) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |