Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CAMLG_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CAMLG_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CAMLG_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAMLG_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAMLG_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAMLG_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAMLG_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CAMLG_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CAMLG_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190305017 | Endometrium | EEC | regulation of proteolysis involved in cellular protein catabolic process | 60/2168 | 221/18723 | 1.46e-10 | 1.69e-08 | 60 |
GO:004316117 | Endometrium | EEC | proteasome-mediated ubiquitin-dependent protein catabolic process | 92/2168 | 412/18723 | 3.01e-10 | 3.23e-08 | 92 |
GO:003139717 | Endometrium | EEC | negative regulation of protein ubiquitination | 31/2168 | 83/18723 | 1.05e-09 | 9.13e-08 | 31 |
GO:200005817 | Endometrium | EEC | regulation of ubiquitin-dependent protein catabolic process | 47/2168 | 164/18723 | 2.09e-09 | 1.72e-07 | 47 |
GO:190332117 | Endometrium | EEC | negative regulation of protein modification by small protein conjugation or removal | 33/2168 | 95/18723 | 2.68e-09 | 2.01e-07 | 33 |
GO:006113617 | Endometrium | EEC | regulation of proteasomal protein catabolic process | 51/2168 | 187/18723 | 2.91e-09 | 2.10e-07 | 51 |
GO:003243417 | Endometrium | EEC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 39/2168 | 134/18723 | 3.01e-08 | 1.71e-06 | 39 |
GO:004217716 | Endometrium | EEC | negative regulation of protein catabolic process | 35/2168 | 121/18723 | 1.79e-07 | 8.20e-06 | 35 |
GO:190336314 | Endometrium | EEC | negative regulation of cellular protein catabolic process | 25/2168 | 75/18723 | 5.43e-07 | 2.04e-05 | 25 |
GO:004586117 | Endometrium | EEC | negative regulation of proteolysis | 72/2168 | 351/18723 | 8.46e-07 | 2.98e-05 | 72 |
GO:200005916 | Endometrium | EEC | negative regulation of ubiquitin-dependent protein catabolic process | 18/2168 | 48/18723 | 3.08e-06 | 8.48e-05 | 18 |
GO:190305114 | Endometrium | EEC | negative regulation of proteolysis involved in cellular protein catabolic process | 21/2168 | 64/18723 | 5.73e-06 | 1.40e-04 | 21 |
GO:003133017 | Endometrium | EEC | negative regulation of cellular catabolic process | 55/2168 | 262/18723 | 7.93e-06 | 1.80e-04 | 55 |
GO:009015015 | Endometrium | EEC | establishment of protein localization to membrane | 52/2168 | 260/18723 | 5.46e-05 | 8.64e-04 | 52 |
GO:000989516 | Endometrium | EEC | negative regulation of catabolic process | 61/2168 | 320/18723 | 5.76e-05 | 8.97e-04 | 61 |
GO:190179911 | Endometrium | EEC | negative regulation of proteasomal protein catabolic process | 16/2168 | 49/18723 | 7.80e-05 | 1.13e-03 | 16 |
GO:003243512 | Endometrium | EEC | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 13/2168 | 35/18723 | 8.13e-05 | 1.17e-03 | 13 |
GO:004887217 | Endometrium | EEC | homeostasis of number of cells | 53/2168 | 272/18723 | 9.52e-05 | 1.34e-03 | 53 |
GO:005120512 | Endometrium | EEC | protein insertion into membrane | 14/2168 | 57/18723 | 4.65e-03 | 2.97e-02 | 14 |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMLG | SNV | Missense_Mutation | rs143564828 | c.310N>A | p.Glu104Lys | p.E104K | P49069 | protein_coding | deleterious(0.01) | benign(0.266) | TCGA-HM-A3JK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CAMLG | SNV | Missense_Mutation | novel | c.133N>C | p.Asn45His | p.N45H | P49069 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | | c.71C>T | p.Ala24Val | p.A24V | P49069 | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.558) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | rs751766092 | c.566N>A | p.Arg189Gln | p.R189Q | P49069 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.946) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | rs765331970 | c.763N>A | p.Glu255Lys | p.E255K | P49069 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | novel | c.308N>T | p.Ala103Val | p.A103V | P49069 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | novel | c.204N>T | p.Gln68His | p.Q68H | P49069 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | rs757373789 | c.446N>A | p.Arg149His | p.R149H | P49069 | protein_coding | tolerated_low_confidence(0.19) | benign(0.006) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMLG | SNV | Missense_Mutation | rs765331970 | c.763N>A | p.Glu255Lys | p.E255K | P49069 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
CAMLG | SNV | Missense_Mutation | novel | c.868T>C | p.Tyr290His | p.Y290H | P49069 | protein_coding | deleterious(0.02) | possibly_damaging(0.748) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |