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Gene: ARIH2 |
Gene summary for ARIH2 |
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Gene information | Species | Human | Gene symbol | ARIH2 | Gene ID | 10425 |
Gene name | ariadne RBR E3 ubiquitin protein ligase 2 | |
Gene Alias | ARI2 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | O95376 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10425 | ARIH2 | LZE4T | Human | Esophagus | ESCC | 7.82e-15 | 3.24e-01 | 0.0811 |
10425 | ARIH2 | LZE7T | Human | Esophagus | ESCC | 1.93e-08 | 5.29e-01 | 0.0667 |
10425 | ARIH2 | LZE8T | Human | Esophagus | ESCC | 1.52e-08 | 1.74e-01 | 0.067 |
10425 | ARIH2 | LZE22D1 | Human | Esophagus | HGIN | 1.47e-04 | 1.09e-01 | 0.0595 |
10425 | ARIH2 | LZE22T | Human | Esophagus | ESCC | 1.28e-02 | 3.55e-01 | 0.068 |
10425 | ARIH2 | LZE24D1 | Human | Esophagus | HGIN | 2.00e-02 | 4.02e-01 | 0.054 |
10425 | ARIH2 | LZE24T | Human | Esophagus | ESCC | 1.01e-23 | 5.73e-01 | 0.0596 |
10425 | ARIH2 | LZE6T | Human | Esophagus | ESCC | 9.15e-04 | 1.71e-01 | 0.0845 |
10425 | ARIH2 | P1T-E | Human | Esophagus | ESCC | 3.36e-09 | 3.12e-01 | 0.0875 |
10425 | ARIH2 | P2T-E | Human | Esophagus | ESCC | 1.01e-18 | 3.87e-01 | 0.1177 |
10425 | ARIH2 | P4T-E | Human | Esophagus | ESCC | 2.40e-26 | 7.56e-01 | 0.1323 |
10425 | ARIH2 | P5T-E | Human | Esophagus | ESCC | 2.60e-06 | 2.07e-01 | 0.1327 |
10425 | ARIH2 | P8T-E | Human | Esophagus | ESCC | 4.80e-21 | 3.28e-01 | 0.0889 |
10425 | ARIH2 | P9T-E | Human | Esophagus | ESCC | 1.25e-12 | 3.49e-01 | 0.1131 |
10425 | ARIH2 | P10T-E | Human | Esophagus | ESCC | 4.40e-20 | 4.28e-01 | 0.116 |
10425 | ARIH2 | P11T-E | Human | Esophagus | ESCC | 3.80e-16 | 5.33e-01 | 0.1426 |
10425 | ARIH2 | P12T-E | Human | Esophagus | ESCC | 4.17e-26 | 6.51e-01 | 0.1122 |
10425 | ARIH2 | P15T-E | Human | Esophagus | ESCC | 1.34e-21 | 4.95e-01 | 0.1149 |
10425 | ARIH2 | P16T-E | Human | Esophagus | ESCC | 2.75e-20 | 4.95e-01 | 0.1153 |
10425 | ARIH2 | P17T-E | Human | Esophagus | ESCC | 2.02e-04 | 2.60e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190374711 | Liver | HCC | regulation of establishment of protein localization to mitochondrion | 41/7958 | 50/18723 | 1.14e-08 | 2.83e-07 | 41 |
GO:190321411 | Liver | HCC | regulation of protein targeting to mitochondrion | 36/7958 | 44/18723 | 1.02e-07 | 1.98e-06 | 36 |
GO:007053411 | Liver | HCC | protein K63-linked ubiquitination | 39/7958 | 56/18723 | 3.63e-05 | 3.61e-04 | 39 |
GO:004858811 | Liver | HCC | developmental cell growth | 121/7958 | 234/18723 | 2.68e-03 | 1.28e-02 | 121 |
GO:001049820 | Oral cavity | OSCC | proteasomal protein catabolic process | 336/7305 | 490/18723 | 5.45e-41 | 8.63e-38 | 336 |
GO:004316120 | Oral cavity | OSCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 285/7305 | 412/18723 | 5.68e-36 | 5.99e-33 | 285 |
GO:007259418 | Oral cavity | OSCC | establishment of protein localization to organelle | 284/7305 | 422/18723 | 1.50e-32 | 1.35e-29 | 284 |
GO:000989620 | Oral cavity | OSCC | positive regulation of catabolic process | 307/7305 | 492/18723 | 2.29e-26 | 7.64e-24 | 307 |
GO:003133120 | Oral cavity | OSCC | positive regulation of cellular catabolic process | 273/7305 | 427/18723 | 6.39e-26 | 2.02e-23 | 273 |
GO:004217620 | Oral cavity | OSCC | regulation of protein catabolic process | 254/7305 | 391/18723 | 1.07e-25 | 3.22e-23 | 254 |
GO:004586220 | Oral cavity | OSCC | positive regulation of proteolysis | 236/7305 | 372/18723 | 6.53e-22 | 1.38e-19 | 236 |
GO:003238615 | Oral cavity | OSCC | regulation of intracellular transport | 218/7305 | 337/18723 | 6.91e-22 | 1.41e-19 | 218 |
GO:190336220 | Oral cavity | OSCC | regulation of cellular protein catabolic process | 174/7305 | 255/18723 | 2.04e-21 | 3.70e-19 | 174 |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:190305020 | Oral cavity | OSCC | regulation of proteolysis involved in cellular protein catabolic process | 152/7305 | 221/18723 | 2.16e-19 | 3.15e-17 | 152 |
GO:003315718 | Oral cavity | OSCC | regulation of intracellular protein transport | 155/7305 | 229/18723 | 1.05e-18 | 1.28e-16 | 155 |
GO:006113620 | Oral cavity | OSCC | regulation of proteasomal protein catabolic process | 132/7305 | 187/18723 | 1.57e-18 | 1.81e-16 | 132 |
GO:190382920 | Oral cavity | OSCC | positive regulation of cellular protein localization | 179/7305 | 276/18723 | 2.20e-18 | 2.41e-16 | 179 |
GO:200005820 | Oral cavity | OSCC | regulation of ubiquitin-dependent protein catabolic process | 118/7305 | 164/18723 | 9.37e-18 | 9.27e-16 | 118 |
GO:003243420 | Oral cavity | OSCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/7305 | 134/18723 | 4.72e-17 | 4.04e-15 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARIH2 | SNV | Missense_Mutation | c.782N>A | p.Arg261His | p.R261H | O95376 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
ARIH2 | SNV | Missense_Mutation | novel | c.1295A>T | p.Tyr432Phe | p.Y432F | O95376 | protein_coding | deleterious(0.03) | possibly_damaging(0.788) | TCGA-UC-A7PD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ARIH2 | SNV | Missense_Mutation | c.980T>C | p.Leu327Pro | p.L327P | O95376 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARIH2 | SNV | Missense_Mutation | c.923G>T | p.Gly308Val | p.G308V | O95376 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
ARIH2 | SNV | Missense_Mutation | c.760N>A | p.Glu254Lys | p.E254K | O95376 | protein_coding | deleterious(0.03) | possibly_damaging(0.585) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARIH2 | SNV | Missense_Mutation | novel | c.828N>C | p.Trp276Cys | p.W276C | O95376 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.323N>A | p.Arg108Lys | p.R108K | O95376 | protein_coding | tolerated(0.85) | benign(0.014) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.323N>T | p.Arg108Ile | p.R108I | O95376 | protein_coding | tolerated(0.14) | possibly_damaging(0.473) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.1244N>G | p.Lys415Arg | p.K415R | O95376 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.118G>A | p.Val40Met | p.V40M | O95376 | protein_coding | tolerated(0.13) | benign(0.038) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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