GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003003812 | Liver | Cirrhotic | contractile actin filament bundle assembly | 42/4634 | 106/18723 | 4.99e-04 | 3.98e-03 | 42 |
GO:004314912 | Liver | Cirrhotic | stress fiber assembly | 42/4634 | 106/18723 | 4.99e-04 | 3.98e-03 | 42 |
GO:003223112 | Liver | Cirrhotic | regulation of actin filament bundle assembly | 41/4634 | 105/18723 | 8.18e-04 | 5.97e-03 | 41 |
GO:00715013 | Liver | Cirrhotic | cellular response to sterol depletion | 10/4634 | 16/18723 | 1.51e-03 | 9.91e-03 | 10 |
GO:011002012 | Liver | Cirrhotic | regulation of actomyosin structure organization | 38/4634 | 100/18723 | 2.22e-03 | 1.35e-02 | 38 |
GO:005149212 | Liver | Cirrhotic | regulation of stress fiber assembly | 35/4634 | 91/18723 | 2.56e-03 | 1.53e-02 | 35 |
GO:00329333 | Liver | Cirrhotic | SREBP signaling pathway | 9/4634 | 15/18723 | 3.88e-03 | 2.10e-02 | 9 |
GO:00069912 | Liver | Cirrhotic | response to sterol depletion | 10/4634 | 18/18723 | 5.00e-03 | 2.59e-02 | 10 |
GO:00322337 | Liver | Cirrhotic | positive regulation of actin filament bundle assembly | 25/4634 | 63/18723 | 6.24e-03 | 3.10e-02 | 25 |
GO:190290322 | Liver | HCC | regulation of supramolecular fiber organization | 224/7958 | 383/18723 | 1.54e-10 | 5.33e-09 | 224 |
GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
GO:190290522 | Liver | HCC | positive regulation of supramolecular fiber organization | 131/7958 | 209/18723 | 2.85e-09 | 7.69e-08 | 131 |
GO:005149522 | Liver | HCC | positive regulation of cytoskeleton organization | 138/7958 | 226/18723 | 1.26e-08 | 3.12e-07 | 138 |
GO:000698411 | Liver | HCC | ER-nucleus signaling pathway | 38/7958 | 46/18723 | 2.68e-08 | 6.17e-07 | 38 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:003295622 | Liver | HCC | regulation of actin cytoskeleton organization | 202/7958 | 358/18723 | 6.18e-08 | 1.29e-06 | 202 |
GO:011005322 | Liver | HCC | regulation of actin filament organization | 158/7958 | 278/18723 | 9.01e-07 | 1.37e-05 | 158 |
GO:005101722 | Liver | HCC | actin filament bundle assembly | 96/7958 | 157/18723 | 1.81e-06 | 2.52e-05 | 96 |
GO:006157222 | Liver | HCC | actin filament bundle organization | 97/7958 | 161/18723 | 4.04e-06 | 5.22e-05 | 97 |
GO:00069911 | Liver | HCC | response to sterol depletion | 17/7958 | 18/18723 | 5.15e-06 | 6.44e-05 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF10L | SNV | Missense_Mutation | | c.1639N>T | p.Val547Leu | p.V547L | Q9HCE6 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
ARHGEF10L | SNV | Missense_Mutation | | c.1094N>A | p.Arg365His | p.R365H | Q9HCE6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF10L | SNV | Missense_Mutation | | c.1489G>A | p.Ala497Thr | p.A497T | Q9HCE6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF10L | SNV | Missense_Mutation | | c.1042N>A | p.Glu348Lys | p.E348K | Q9HCE6 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-E2-A1L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ARHGEF10L | SNV | Missense_Mutation | | c.2288N>G | p.Pro763Arg | p.P763R | Q9HCE6 | protein_coding | tolerated(0.22) | probably_damaging(0.983) | TCGA-E9-A1NF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
ARHGEF10L | insertion | Nonsense_Mutation | novel | c.2470_2471insTAGTCATTCAGGAGCAGGTACTCTCAGAAAATTCTTTGTGACGAT | p.Gly824delinsValValIleGlnGluGlnValLeuSerGluAsnSerLeuTerArgCys | p.G824delinsVVIQEQVLSENSL*RC | Q9HCE6 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF10L | deletion | Frame_Shift_Del | | c.186delN | p.Pro64HisfsTer2 | p.P64Hfs*2 | Q9HCE6 | protein_coding | | | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ARHGEF10L | deletion | Frame_Shift_Del | novel | c.1008delG | p.Lys336AsnfsTer11 | p.K336Nfs*11 | Q9HCE6 | protein_coding | | | TCGA-LL-A740-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ARHGEF10L | SNV | Missense_Mutation | rs776413301 | c.1384T>C | p.Phe462Leu | p.F462L | Q9HCE6 | protein_coding | deleterious(0.02) | benign(0.073) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARHGEF10L | SNV | Missense_Mutation | | c.2334N>G | p.Phe778Leu | p.F778L | Q9HCE6 | protein_coding | tolerated(0.67) | possibly_damaging(0.81) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |