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Gene: APRT |
Gene summary for APRT |
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Gene information | Species | Human | Gene symbol | APRT | Gene ID | 353 |
Gene name | adenine phosphoribosyltransferase | |
Gene Alias | AMP | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P07741 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
353 | APRT | GSM4909286 | Human | Breast | IDC | 1.66e-05 | 2.08e-01 | 0.1081 |
353 | APRT | GSM4909288 | Human | Breast | IDC | 7.20e-09 | 7.16e-02 | 0.0988 |
353 | APRT | GSM4909291 | Human | Breast | IDC | 4.51e-05 | 2.59e-01 | 0.1753 |
353 | APRT | GSM4909294 | Human | Breast | IDC | 1.92e-26 | 4.04e-01 | 0.2022 |
353 | APRT | GSM4909296 | Human | Breast | IDC | 1.37e-28 | 2.64e-01 | 0.1524 |
353 | APRT | GSM4909297 | Human | Breast | IDC | 1.53e-32 | -4.88e-01 | 0.1517 |
353 | APRT | GSM4909304 | Human | Breast | IDC | 2.26e-27 | 5.38e-01 | 0.1636 |
353 | APRT | GSM4909309 | Human | Breast | IDC | 2.44e-04 | -2.68e-01 | 0.0483 |
353 | APRT | GSM4909311 | Human | Breast | IDC | 1.11e-49 | -5.29e-01 | 0.1534 |
353 | APRT | GSM4909312 | Human | Breast | IDC | 4.52e-22 | -3.35e-01 | 0.1552 |
353 | APRT | GSM4909313 | Human | Breast | IDC | 1.88e-05 | -2.95e-01 | 0.0391 |
353 | APRT | GSM4909315 | Human | Breast | IDC | 4.23e-02 | -2.91e-02 | 0.21 |
353 | APRT | GSM4909316 | Human | Breast | IDC | 5.81e-13 | 2.77e-01 | 0.21 |
353 | APRT | GSM4909318 | Human | Breast | IDC | 1.54e-06 | 3.24e-01 | 0.2031 |
353 | APRT | GSM4909319 | Human | Breast | IDC | 6.03e-67 | -3.96e-01 | 0.1563 |
353 | APRT | GSM4909320 | Human | Breast | IDC | 1.06e-16 | 1.17e-01 | 0.1575 |
353 | APRT | GSM4909321 | Human | Breast | IDC | 4.17e-29 | 4.59e-02 | 0.1559 |
353 | APRT | brca1 | Human | Breast | Precancer | 2.51e-26 | 5.29e-01 | -0.0338 |
353 | APRT | brca2 | Human | Breast | Precancer | 2.59e-04 | 2.82e-01 | -0.024 |
353 | APRT | M2 | Human | Breast | IDC | 3.45e-26 | 6.64e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075891 | Colorectum | SER | body fluid secretion | 26/2897 | 93/18723 | 1.49e-03 | 1.60e-02 | 26 |
GO:00091261 | Colorectum | SER | purine nucleoside monophosphate metabolic process | 15/2897 | 44/18723 | 1.77e-03 | 1.82e-02 | 15 |
GO:00091671 | Colorectum | SER | purine ribonucleoside monophosphate metabolic process | 14/2897 | 41/18723 | 2.45e-03 | 2.32e-02 | 14 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00061632 | Colorectum | MSS | purine nucleotide metabolic process | 128/3467 | 396/18723 | 2.04e-11 | 3.02e-09 | 128 |
GO:00091502 | Colorectum | MSS | purine ribonucleotide metabolic process | 121/3467 | 368/18723 | 2.08e-11 | 3.02e-09 | 121 |
GO:00725212 | Colorectum | MSS | purine-containing compound metabolic process | 132/3467 | 416/18723 | 4.13e-11 | 4.86e-09 | 132 |
GO:00092592 | Colorectum | MSS | ribonucleotide metabolic process | 123/3467 | 385/18723 | 1.17e-10 | 1.20e-08 | 123 |
GO:00196932 | Colorectum | MSS | ribose phosphate metabolic process | 124/3467 | 396/18723 | 4.11e-10 | 3.49e-08 | 124 |
GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
GO:00067532 | Colorectum | MSS | nucleoside phosphate metabolic process | 145/3467 | 497/18723 | 3.25e-09 | 2.23e-07 | 145 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00091522 | Colorectum | MSS | purine ribonucleotide biosynthetic process | 57/3467 | 169/18723 | 1.63e-06 | 5.32e-05 | 57 |
GO:00092602 | Colorectum | MSS | ribonucleotide biosynthetic process | 59/3467 | 182/18723 | 4.55e-06 | 1.27e-04 | 59 |
GO:00463902 | Colorectum | MSS | ribose phosphate biosynthetic process | 60/3467 | 190/18723 | 9.54e-06 | 2.33e-04 | 60 |
GO:00061642 | Colorectum | MSS | purine nucleotide biosynthetic process | 59/3467 | 191/18723 | 2.36e-05 | 4.97e-04 | 59 |
GO:00725222 | Colorectum | MSS | purine-containing compound biosynthetic process | 61/3467 | 200/18723 | 2.65e-05 | 5.46e-04 | 61 |
GO:00091262 | Colorectum | MSS | purine nucleoside monophosphate metabolic process | 19/3467 | 44/18723 | 1.38e-04 | 2.06e-03 | 19 |
GO:00508782 | Colorectum | MSS | regulation of body fluid levels | 99/3467 | 379/18723 | 1.40e-04 | 2.07e-03 | 99 |
GO:00091672 | Colorectum | MSS | purine ribonucleoside monophosphate metabolic process | 18/3467 | 41/18723 | 1.60e-04 | 2.29e-03 | 18 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APRT | SNV | Missense_Mutation | novel | c.277C>T | p.Pro93Ser | p.P93S | P07741 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
APRT | SNV | Missense_Mutation | c.496N>A | p.Glu166Lys | p.E166K | P07741 | protein_coding | tolerated(0.19) | benign(0.049) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
APRT | SNV | Missense_Mutation | rs752166198 | c.265N>T | p.Arg89Trp | p.R89W | P07741 | protein_coding | deleterious(0) | possibly_damaging(0.831) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APRT | SNV | Missense_Mutation | c.524N>A | p.Ser175Tyr | p.S175Y | P07741 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
APRT | SNV | Missense_Mutation | novel | c.296C>T | p.Ala99Val | p.A99V | P07741 | protein_coding | tolerated(1) | benign(0.001) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
APRT | SNV | Missense_Mutation | novel | c.443N>T | p.Ala148Val | p.A148V | P07741 | protein_coding | tolerated(0.08) | probably_damaging(0.985) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APRT | SNV | Missense_Mutation | novel | c.112N>C | p.Ser38Pro | p.S38P | P07741 | protein_coding | deleterious(0.02) | possibly_damaging(0.794) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APRT | SNV | Missense_Mutation | c.363G>C | p.Gln121His | p.Q121H | P07741 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APRT | SNV | Missense_Mutation | c.363N>C | p.Gln121His | p.Q121H | P07741 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APRT | SNV | Missense_Mutation | rs117335001 | c.260N>A | p.Arg87Gln | p.R87Q | P07741 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-68-8250-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
353 | APRT | ENZYME, DRUGGABLE GENOME | TPA | ALTEPLASE | 6933001 | |
353 | APRT | ENZYME, DRUGGABLE GENOME | HYDROGEN PEROXIDE | 10213488 |
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