Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ALKBH5_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ALKBH5_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ALKBH5_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ALKBH5_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ALKBH5_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ALKBH5_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ALKBH5_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00159316 | Liver | Cirrhotic | nucleobase-containing compound transport | 87/4634 | 222/18723 | 1.25e-06 | 2.52e-05 | 87 |
GO:00704827 | Liver | Cirrhotic | response to oxygen levels | 125/4634 | 347/18723 | 1.55e-06 | 3.02e-05 | 125 |
GO:00510282 | Liver | Cirrhotic | mRNA transport | 56/4634 | 130/18723 | 3.47e-06 | 5.97e-05 | 56 |
GO:00362937 | Liver | Cirrhotic | response to decreased oxygen levels | 113/4634 | 322/18723 | 1.87e-05 | 2.52e-04 | 113 |
GO:00016667 | Liver | Cirrhotic | response to hypoxia | 108/4634 | 307/18723 | 2.51e-05 | 3.26e-04 | 108 |
GO:0071166 | Liver | Cirrhotic | ribonucleoprotein complex localization | 32/4634 | 77/18723 | 8.65e-04 | 6.23e-03 | 32 |
GO:00064052 | Liver | Cirrhotic | RNA export from nucleus | 34/4634 | 84/18723 | 1.06e-03 | 7.40e-03 | 34 |
GO:0031503 | Liver | Cirrhotic | protein-containing complex localization | 75/4634 | 220/18723 | 1.13e-03 | 7.73e-03 | 75 |
GO:0071426 | Liver | Cirrhotic | ribonucleoprotein complex export from nucleus | 31/4634 | 76/18723 | 1.49e-03 | 9.87e-03 | 31 |
GO:0070989 | Liver | Cirrhotic | oxidative demethylation | 10/4634 | 19/18723 | 8.23e-03 | 3.83e-02 | 10 |
GO:00064062 | Liver | Cirrhotic | mRNA export from nucleus | 23/4634 | 59/18723 | 1.08e-02 | 4.77e-02 | 23 |
GO:00714272 | Liver | Cirrhotic | mRNA-containing ribonucleoprotein complex export from nucleus | 23/4634 | 59/18723 | 1.08e-02 | 4.77e-02 | 23 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:000640121 | Liver | HCC | RNA catabolic process | 201/7958 | 278/18723 | 3.88e-24 | 1.02e-21 | 201 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:190331121 | Liver | HCC | regulation of mRNA metabolic process | 205/7958 | 288/18723 | 3.38e-23 | 6.90e-21 | 205 |
GO:000640321 | Liver | HCC | RNA localization | 151/7958 | 201/18723 | 3.72e-21 | 5.89e-19 | 151 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALKBH5 | SNV | Missense_Mutation | novel | c.579N>G | p.Asn193Lys | p.N193K | Q6P6C2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
ALKBH5 | SNV | Missense_Mutation | | c.877N>C | p.Glu293Gln | p.E293Q | Q6P6C2 | protein_coding | deleterious(0.04) | possibly_damaging(0.484) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ALKBH5 | SNV | Missense_Mutation | | c.871N>T | p.Arg291Trp | p.R291W | Q6P6C2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AO-A0J3-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | SD |
ALKBH5 | SNV | Missense_Mutation | novel | c.458N>G | p.Glu153Gly | p.E153G | Q6P6C2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-D8-A140-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin+cyclophosphamid | SD |
ALKBH5 | insertion | Nonsense_Mutation | novel | c.1030_1031insTTGATTCTCAAGAGATGGCTTATGGGTCTTCGGGGCCTTG | p.Lys344IlefsTer14 | p.K344Ifs*14 | Q6P6C2 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
ALKBH5 | SNV | Missense_Mutation | | c.979N>T | p.Arg327Cys | p.R327C | Q6P6C2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.88) | TCGA-C5-A1MJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ALKBH5 | SNV | Missense_Mutation | | c.1168N>G | p.Lys390Glu | p.K390E | Q6P6C2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ALKBH5 | SNV | Missense_Mutation | rs751699434 | c.1117N>A | p.Glu373Lys | p.E373K | Q6P6C2 | protein_coding | tolerated_low_confidence(0.09) | benign(0.212) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ALKBH5 | SNV | Missense_Mutation | | c.686G>A | p.Gly229Asp | p.G229D | Q6P6C2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ALKBH5 | SNV | Missense_Mutation | | c.245N>T | p.Ala82Val | p.A82V | Q6P6C2 | protein_coding | tolerated(0.44) | possibly_damaging(0.837) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |