![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ALDH3A1 |
Gene summary for ALDH3A1 |
![]() |
Gene information | Species | Human | Gene symbol | ALDH3A1 | Gene ID | 218 |
Gene name | aldehyde dehydrogenase 3 family member A1 | |
Gene Alias | ALDH3 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | P30838 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
218 | ALDH3A1 | LZE2T | Human | Esophagus | ESCC | 5.11e-15 | 2.93e+00 | 0.082 |
218 | ALDH3A1 | LZE4T | Human | Esophagus | ESCC | 1.88e-16 | 2.08e+00 | 0.0811 |
218 | ALDH3A1 | LZE7T | Human | Esophagus | ESCC | 3.14e-09 | 2.08e+00 | 0.0667 |
218 | ALDH3A1 | LZE21D1 | Human | Esophagus | HGIN | 6.77e-04 | 2.21e+00 | 0.0632 |
218 | ALDH3A1 | LZE22D1 | Human | Esophagus | HGIN | 2.87e-06 | 1.44e+00 | 0.0595 |
218 | ALDH3A1 | LZE22T | Human | Esophagus | ESCC | 7.40e-04 | 1.42e+00 | 0.068 |
218 | ALDH3A1 | LZE21T | Human | Esophagus | ESCC | 1.19e-09 | 2.10e+00 | 0.0655 |
218 | ALDH3A1 | P2T-E | Human | Esophagus | ESCC | 1.91e-16 | -4.95e-01 | 0.1177 |
218 | ALDH3A1 | P4T-E | Human | Esophagus | ESCC | 3.85e-26 | 1.88e+00 | 0.1323 |
218 | ALDH3A1 | P5T-E | Human | Esophagus | ESCC | 5.87e-16 | -1.97e-01 | 0.1327 |
218 | ALDH3A1 | P8T-E | Human | Esophagus | ESCC | 2.77e-04 | 4.60e-01 | 0.0889 |
218 | ALDH3A1 | P9T-E | Human | Esophagus | ESCC | 8.04e-49 | 2.67e+00 | 0.1131 |
218 | ALDH3A1 | P10T-E | Human | Esophagus | ESCC | 1.16e-13 | -1.49e-01 | 0.116 |
218 | ALDH3A1 | P15T-E | Human | Esophagus | ESCC | 3.13e-21 | 1.51e+00 | 0.1149 |
218 | ALDH3A1 | P16T-E | Human | Esophagus | ESCC | 1.89e-17 | -4.76e-01 | 0.1153 |
218 | ALDH3A1 | P20T-E | Human | Esophagus | ESCC | 6.89e-13 | 1.27e+00 | 0.1124 |
218 | ALDH3A1 | P21T-E | Human | Esophagus | ESCC | 4.54e-18 | 2.11e+00 | 0.1617 |
218 | ALDH3A1 | P22T-E | Human | Esophagus | ESCC | 5.29e-44 | 1.48e+00 | 0.1236 |
218 | ALDH3A1 | P27T-E | Human | Esophagus | ESCC | 4.80e-52 | 2.33e+00 | 0.1055 |
218 | ALDH3A1 | P28T-E | Human | Esophagus | ESCC | 3.59e-24 | 1.75e+00 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004854521 | Stomach | CSG | response to steroid hormone | 40/1034 | 339/18723 | 4.99e-06 | 1.94e-04 | 40 |
GO:003166721 | Stomach | CSG | response to nutrient levels | 49/1034 | 474/18723 | 1.83e-05 | 5.57e-04 | 49 |
GO:00515912 | Stomach | CSG | response to cAMP | 14/1034 | 93/18723 | 5.62e-04 | 8.29e-03 | 14 |
GO:00466832 | Stomach | CSG | response to organophosphorus | 17/1034 | 131/18723 | 8.87e-04 | 1.18e-02 | 17 |
GO:000756821 | Stomach | CSG | aging | 33/1034 | 339/18723 | 1.16e-03 | 1.42e-02 | 33 |
GO:003629321 | Stomach | CSG | response to decreased oxygen levels | 31/1034 | 322/18723 | 1.91e-03 | 2.02e-02 | 31 |
GO:00068052 | Stomach | CSG | xenobiotic metabolic process | 14/1034 | 111/18723 | 3.18e-03 | 2.92e-02 | 14 |
GO:007048221 | Stomach | CSG | response to oxygen levels | 32/1034 | 347/18723 | 3.20e-03 | 2.92e-02 | 32 |
GO:00140742 | Stomach | CSG | response to purine-containing compound | 17/1034 | 148/18723 | 3.35e-03 | 3.04e-02 | 17 |
GO:000166621 | Stomach | CSG | response to hypoxia | 29/1034 | 307/18723 | 3.46e-03 | 3.12e-02 | 29 |
GO:00075842 | Stomach | CSG | response to nutrient | 19/1034 | 174/18723 | 3.54e-03 | 3.18e-02 | 19 |
GO:000608121 | Stomach | CSG | cellular aldehyde metabolic process | 9/1034 | 60/18723 | 5.38e-03 | 4.33e-02 | 9 |
GO:000941031 | Stomach | CAG | response to xenobiotic stimulus | 35/552 | 462/18723 | 3.65e-07 | 2.85e-05 | 35 |
GO:00319603 | Stomach | CAG | response to corticosteroid | 18/552 | 167/18723 | 2.26e-06 | 1.23e-04 | 18 |
GO:004854531 | Stomach | CAG | response to steroid hormone | 27/552 | 339/18723 | 3.15e-06 | 1.55e-04 | 27 |
GO:00513843 | Stomach | CAG | response to glucocorticoid | 16/552 | 148/18723 | 7.91e-06 | 3.46e-04 | 16 |
GO:003166731 | Stomach | CAG | response to nutrient levels | 32/552 | 474/18723 | 1.28e-05 | 5.12e-04 | 32 |
GO:003629331 | Stomach | CAG | response to decreased oxygen levels | 24/552 | 322/18723 | 3.28e-05 | 1.09e-03 | 24 |
GO:007048231 | Stomach | CAG | response to oxygen levels | 25/552 | 347/18723 | 3.97e-05 | 1.28e-03 | 25 |
GO:000166631 | Stomach | CAG | response to hypoxia | 22/552 | 307/18723 | 1.23e-04 | 3.03e-03 | 22 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0001016 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0001017 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa004102 | Liver | HCC | beta-Alanine metabolism | 22/4020 | 31/8465 | 6.93e-03 | 1.92e-02 | 1.07e-02 | 22 |
hsa004103 | Liver | HCC | beta-Alanine metabolism | 22/4020 | 31/8465 | 6.93e-03 | 1.92e-02 | 1.07e-02 | 22 |
hsa0001014 | Oral cavity | OSCC | Glycolysis / Gluconeogenesis | 40/3704 | 67/8465 | 6.08e-03 | 1.44e-02 | 7.31e-03 | 40 |
hsa0001015 | Oral cavity | OSCC | Glycolysis / Gluconeogenesis | 40/3704 | 67/8465 | 6.08e-03 | 1.44e-02 | 7.31e-03 | 40 |
hsa0001023 | Oral cavity | LP | Glycolysis / Gluconeogenesis | 28/2418 | 67/8465 | 1.36e-02 | 4.44e-02 | 2.86e-02 | 28 |
hsa0001033 | Oral cavity | LP | Glycolysis / Gluconeogenesis | 28/2418 | 67/8465 | 1.36e-02 | 4.44e-02 | 2.86e-02 | 28 |
hsa000108 | Stomach | GC | Glycolysis / Gluconeogenesis | 14/708 | 67/8465 | 1.08e-03 | 7.69e-03 | 5.41e-03 | 14 |
hsa00980 | Stomach | GC | Metabolism of xenobiotics by cytochrome P450 | 15/708 | 78/8465 | 1.77e-03 | 1.16e-02 | 8.15e-03 | 15 |
hsa0001011 | Stomach | GC | Glycolysis / Gluconeogenesis | 14/708 | 67/8465 | 1.08e-03 | 7.69e-03 | 5.41e-03 | 14 |
hsa009801 | Stomach | GC | Metabolism of xenobiotics by cytochrome P450 | 15/708 | 78/8465 | 1.77e-03 | 1.16e-02 | 8.15e-03 | 15 |
hsa0001041 | Stomach | SIM | Glycolysis / Gluconeogenesis | 13/465 | 67/8465 | 5.81e-05 | 6.73e-04 | 5.40e-04 | 13 |
hsa009802 | Stomach | SIM | Metabolism of xenobiotics by cytochrome P450 | 11/465 | 78/8465 | 3.37e-03 | 2.18e-02 | 1.75e-02 | 11 |
hsa0001051 | Stomach | SIM | Glycolysis / Gluconeogenesis | 13/465 | 67/8465 | 5.81e-05 | 6.73e-04 | 5.40e-04 | 13 |
hsa009803 | Stomach | SIM | Metabolism of xenobiotics by cytochrome P450 | 11/465 | 78/8465 | 3.37e-03 | 2.18e-02 | 1.75e-02 | 11 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDH3A1 | insertion | Frame_Shift_Ins | novel | c.1334_1335insC | p.Ser446GlufsTer51 | p.S446Efs*51 | P30838 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ALDH3A1 | SNV | Missense_Mutation | c.982T>C | p.Ser328Pro | p.S328P | P30838 | protein_coding | deleterious(0.03) | probably_damaging(0.969) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ALDH3A1 | SNV | Missense_Mutation | c.941N>A | p.Arg314His | p.R314H | P30838 | protein_coding | tolerated(0.12) | probably_damaging(0.926) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
ALDH3A1 | SNV | Missense_Mutation | rs545815877 | c.440N>T | p.Ala147Val | p.A147V | P30838 | protein_coding | deleterious(0.02) | possibly_damaging(0.874) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ALDH3A1 | SNV | Missense_Mutation | rs774092621 | c.655N>A | p.Val219Met | p.V219M | P30838 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-CM-5344-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
ALDH3A1 | SNV | Missense_Mutation | rs780443108 | c.569N>T | p.Thr190Met | p.T190M | P30838 | protein_coding | deleterious(0.02) | benign(0.193) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ALDH3A1 | SNV | Missense_Mutation | c.340N>C | p.Trp114Arg | p.W114R | P30838 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALDH3A1 | SNV | Missense_Mutation | rs755608749 | c.419N>T | p.Ser140Leu | p.S140L | P30838 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
ALDH3A1 | SNV | Missense_Mutation | novel | c.1325N>T | p.Arg442Ile | p.R442I | P30838 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ALDH3A1 | SNV | Missense_Mutation | rs774582773 | c.1168N>A | p.Asp390Asn | p.D390N | P30838 | protein_coding | deleterious(0.04) | possibly_damaging(0.796) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
218 | ALDH3A1 | DRUGGABLE GENOME, ENZYME | DISULFIRAM | DISULFIRAM | 2185582 | |
218 | ALDH3A1 | DRUGGABLE GENOME, ENZYME | cyclophosphamide | CYCLOPHOSPHAMIDE | ||
218 | ALDH3A1 | DRUGGABLE GENOME, ENZYME | fluorouracil | FLUOROURACIL | ||
218 | ALDH3A1 | DRUGGABLE GENOME, ENZYME | ANTABUSE | ANTABUSE | 7907815 | |
218 | ALDH3A1 | DRUGGABLE GENOME, ENZYME | ETHANOL | ALCOHOL | 15909415,12652939,14987799 | |
218 | ALDH3A1 | DRUGGABLE GENOME, ENZYME | doxorubicin | DOXORUBICIN |
Page: 1 |