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Gene: AHCYL1 |
Gene summary for AHCYL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AHCYL1 | Gene ID | 10768 |
Gene name | adenosylhomocysteinase like 1 | |
Gene Alias | DCAL | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | O43865 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10768 | AHCYL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.61e-07 | 6.84e-01 | -0.0811 |
10768 | AHCYL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.01e-07 | 6.34e-01 | -0.1088 |
10768 | AHCYL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.85e-15 | 7.03e-01 | -0.1954 |
10768 | AHCYL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.47e-04 | 3.89e-01 | -0.1464 |
10768 | AHCYL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.78e-05 | 6.11e-01 | -0.059 |
10768 | AHCYL1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.42e-04 | 7.17e-01 | 0.0131 |
10768 | AHCYL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.71e-09 | 5.48e-01 | 0.294 |
10768 | AHCYL1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.68e-06 | 6.64e-01 | 0.281 |
10768 | AHCYL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.86e-11 | 6.70e-01 | 0.3859 |
10768 | AHCYL1 | A015-C-203 | Human | Colorectum | FAP | 3.42e-12 | -2.47e-01 | -0.1294 |
10768 | AHCYL1 | A002-C-201 | Human | Colorectum | FAP | 1.55e-08 | -2.72e-01 | 0.0324 |
10768 | AHCYL1 | A002-C-203 | Human | Colorectum | FAP | 8.04e-03 | -9.98e-02 | 0.2786 |
10768 | AHCYL1 | A001-C-119 | Human | Colorectum | FAP | 6.59e-08 | -3.51e-01 | -0.1557 |
10768 | AHCYL1 | A001-C-108 | Human | Colorectum | FAP | 1.58e-08 | -2.28e-01 | -0.0272 |
10768 | AHCYL1 | A002-C-205 | Human | Colorectum | FAP | 3.75e-10 | -2.66e-01 | -0.1236 |
10768 | AHCYL1 | A015-C-006 | Human | Colorectum | FAP | 3.23e-07 | -2.86e-01 | -0.0994 |
10768 | AHCYL1 | A015-C-106 | Human | Colorectum | FAP | 8.48e-04 | -1.86e-01 | -0.0511 |
10768 | AHCYL1 | A002-C-114 | Human | Colorectum | FAP | 1.67e-07 | -2.22e-01 | -0.1561 |
10768 | AHCYL1 | A015-C-104 | Human | Colorectum | FAP | 2.25e-12 | -2.78e-01 | -0.1899 |
10768 | AHCYL1 | A001-C-014 | Human | Colorectum | FAP | 4.01e-05 | -1.87e-01 | 0.0135 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005068411 | Liver | Cirrhotic | regulation of mRNA processing | 81/4634 | 137/18723 | 1.05e-17 | 1.60e-15 | 81 |
GO:001003812 | Liver | Cirrhotic | response to metal ion | 150/4634 | 373/18723 | 2.27e-11 | 1.37e-09 | 150 |
GO:000691312 | Liver | Cirrhotic | nucleocytoplasmic transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116912 | Liver | Cirrhotic | nuclear transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
GO:005116812 | Liver | Cirrhotic | nuclear export | 67/4634 | 154/18723 | 2.57e-07 | 6.41e-06 | 67 |
GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
GO:005159211 | Liver | Cirrhotic | response to calcium ion | 61/4634 | 149/18723 | 9.47e-06 | 1.38e-04 | 61 |
GO:00224065 | Liver | Cirrhotic | membrane docking | 39/4634 | 86/18723 | 2.47e-05 | 3.22e-04 | 39 |
GO:00066114 | Liver | Cirrhotic | protein export from nucleus | 27/4634 | 57/18723 | 1.74e-04 | 1.63e-03 | 27 |
GO:19043851 | Liver | Cirrhotic | cellular response to angiotensin | 14/4634 | 25/18723 | 8.15e-04 | 5.95e-03 | 14 |
GO:01400565 | Liver | Cirrhotic | organelle localization by membrane tethering | 32/4634 | 77/18723 | 8.65e-04 | 6.23e-03 | 32 |
GO:19907761 | Liver | Cirrhotic | response to angiotensin | 15/4634 | 28/18723 | 9.91e-04 | 6.98e-03 | 15 |
GO:00107656 | Liver | Cirrhotic | positive regulation of sodium ion transport | 17/4634 | 35/18723 | 1.93e-03 | 1.21e-02 | 17 |
GO:0031440 | Liver | Cirrhotic | regulation of mRNA 3'-end processing | 14/4634 | 28/18723 | 3.40e-03 | 1.89e-02 | 14 |
GO:0031123 | Liver | Cirrhotic | RNA 3'-end processing | 42/4634 | 116/18723 | 3.85e-03 | 2.10e-02 | 42 |
GO:0031124 | Liver | Cirrhotic | mRNA 3'-end processing | 25/4634 | 62/18723 | 4.90e-03 | 2.56e-02 | 25 |
GO:00067303 | Liver | Cirrhotic | one-carbon metabolic process | 17/4634 | 40/18723 | 1.04e-02 | 4.61e-02 | 17 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002704 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa0027011 | Endometrium | EEC | Cysteine and methionine metabolism | 15/1237 | 52/8465 | 6.02e-03 | 3.12e-02 | 2.33e-02 | 15 |
hsa00270 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002701 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCYL1 | SNV | Missense_Mutation | novel | c.1148N>T | p.Glu383Val | p.E383V | O43865 | protein_coding | deleterious(0) | benign(0.062) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
AHCYL1 | SNV | Missense_Mutation | c.909N>T | p.Arg303Ser | p.R303S | O43865 | protein_coding | deleterious(0.02) | possibly_damaging(0.458) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
AHCYL1 | insertion | Frame_Shift_Ins | novel | c.899_899+1insCTCTCTTACTAGTACAGAAAGT | p.Leu301SerfsTer28 | p.L301Sfs*28 | O43865 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
AHCYL1 | SNV | Missense_Mutation | rs538566120 | c.1213N>A | p.Asp405Asn | p.D405N | O43865 | protein_coding | deleterious(0.03) | benign(0.429) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AHCYL1 | SNV | Missense_Mutation | novel | c.305N>A | p.Ser102Asn | p.S102N | O43865 | protein_coding | tolerated(0.51) | benign(0) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AHCYL1 | SNV | Missense_Mutation | novel | c.766G>A | p.Val256Met | p.V256M | O43865 | protein_coding | deleterious(0.03) | probably_damaging(0.92) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
AHCYL1 | SNV | Missense_Mutation | c.361G>A | p.Glu121Lys | p.E121K | O43865 | protein_coding | tolerated(0.07) | possibly_damaging(0.706) | TCGA-ZX-AA5X-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
AHCYL1 | SNV | Missense_Mutation | novel | c.821N>T | p.Pro274Leu | p.P274L | O43865 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
AHCYL1 | SNV | Missense_Mutation | c.409N>A | p.Ala137Thr | p.A137T | O43865 | protein_coding | tolerated(0.36) | benign(0.39) | TCGA-AA-3530-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AHCYL1 | SNV | Missense_Mutation | rs756700510 | c.641G>A | p.Arg214His | p.R214H | O43865 | protein_coding | deleterious(0.03) | benign(0.022) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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