GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0003044 | Stomach | GC | regulation of systemic arterial blood pressure mediated by a chemical signal | 11/1159 | 47/18723 | 1.08e-04 | 2.09e-03 | 11 |
GO:00444096 | Stomach | GC | entry into host | 22/1159 | 151/18723 | 1.55e-04 | 2.81e-03 | 22 |
GO:00467186 | Stomach | GC | viral entry into host cell | 21/1159 | 144/18723 | 2.13e-04 | 3.61e-03 | 21 |
GO:00516045 | Stomach | GC | protein maturation | 34/1159 | 294/18723 | 3.35e-04 | 5.33e-03 | 34 |
GO:0003081 | Stomach | GC | regulation of systemic arterial blood pressure by renin-angiotensin | 7/1159 | 23/18723 | 3.48e-04 | 5.49e-03 | 7 |
GO:00343295 | Stomach | GC | cell junction assembly | 42/1159 | 420/18723 | 1.50e-03 | 1.62e-02 | 42 |
GO:0001991 | Stomach | GC | regulation of systemic arterial blood pressure by circulatory renin-angiotensin | 5/1159 | 16/18723 | 2.21e-03 | 2.18e-02 | 5 |
GO:0003073 | Stomach | GC | regulation of systemic arterial blood pressure | 14/1159 | 96/18723 | 2.29e-03 | 2.21e-02 | 14 |
GO:0008217 | Stomach | GC | regulation of blood pressure | 22/1159 | 186/18723 | 2.66e-03 | 2.46e-02 | 22 |
GO:00069422 | Stomach | GC | regulation of striated muscle contraction | 13/1159 | 95/18723 | 5.64e-03 | 4.34e-02 | 13 |
GO:0001990 | Stomach | GC | regulation of systemic arterial blood pressure by hormone | 7/1159 | 37/18723 | 6.86e-03 | 4.95e-02 | 7 |
GO:001905851 | Stomach | SIM | viral life cycle | 35/708 | 317/18723 | 1.45e-08 | 1.69e-06 | 35 |
GO:001603251 | Stomach | SIM | viral process | 41/708 | 415/18723 | 2.13e-08 | 2.33e-06 | 41 |
GO:004440351 | Stomach | SIM | biological process involved in symbiotic interaction | 30/708 | 290/18723 | 6.39e-07 | 3.87e-05 | 30 |
GO:00725935 | Stomach | SIM | reactive oxygen species metabolic process | 24/708 | 239/18723 | 1.38e-05 | 4.74e-04 | 24 |
GO:005212651 | Stomach | SIM | movement in host environment | 19/708 | 175/18723 | 3.66e-05 | 1.05e-03 | 19 |
GO:005170151 | Stomach | SIM | biological process involved in interaction with host | 20/708 | 203/18723 | 9.18e-05 | 2.28e-03 | 20 |
GO:20003795 | Stomach | SIM | positive regulation of reactive oxygen species metabolic process | 11/708 | 76/18723 | 1.28e-04 | 2.94e-03 | 11 |
GO:00444095 | Stomach | SIM | entry into host | 16/708 | 151/18723 | 1.96e-04 | 4.08e-03 | 16 |
GO:20003775 | Stomach | SIM | regulation of reactive oxygen species metabolic process | 16/708 | 157/18723 | 3.07e-04 | 5.70e-03 | 16 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACE2 | SNV | Missense_Mutation | novel | c.1216G>A | p.Glu406Lys | p.E406K | Q9BYF1 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACE2 | SNV | Missense_Mutation | | c.484N>T | p.Leu162Phe | p.L162F | Q9BYF1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ACE2 | insertion | Nonsense_Mutation | novel | c.1544_1545insCTATTGATTGCTGATGACGGGGACAAGATC | p.Tyr516_Thr517insTer | p.Y516_T517ins* | Q9BYF1 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ACE2 | SNV | Missense_Mutation | novel | c.1854C>G | p.Ile618Met | p.I618M | Q9BYF1 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ACE2 | SNV | Missense_Mutation | novel | c.1371N>C | p.Glu457Asp | p.E457D | Q9BYF1 | protein_coding | tolerated(1) | possibly_damaging(0.536) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ACE2 | SNV | Missense_Mutation | novel | c.2408C>T | p.Thr803Ile | p.T803I | Q9BYF1 | protein_coding | deleterious_low_confidence(0) | benign(0.388) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACE2 | SNV | Missense_Mutation | novel | c.1486A>G | p.Thr496Ala | p.T496A | Q9BYF1 | protein_coding | tolerated(0.24) | benign(0.005) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
ACE2 | SNV | Missense_Mutation | novel | c.1091N>C | p.Val364Ala | p.V364A | Q9BYF1 | protein_coding | deleterious(0) | possibly_damaging(0.502) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACE2 | SNV | Missense_Mutation | novel | c.2269A>G | p.Ile757Val | p.I757V | Q9BYF1 | protein_coding | tolerated_low_confidence(0.58) | benign(0.01) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACE2 | SNV | Missense_Mutation | rs865959788 | c.1010N>A | p.Gly337Glu | p.G337E | Q9BYF1 | protein_coding | tolerated(0.43) | benign(0.023) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | inhibitor | 223366196 | ORE-1001 | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | | GL1001 | ORE-1001 | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | | GSK2586881 | GSK-2586881 | 25893478 |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | | ORE-1001 | ORE-1001 | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | inhibitor | 178103169 | | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | activator | 223366197 | | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | | LISINOPRIL | LISINOPRIL | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | | 178101824 | | |
59272 | ACE2 | ENZYME, TRANSPORTER, DRUGGABLE GENOME, NEUTRAL ZINC METALLOPEPTIDASE, CELL SURFACE, PROTEASE | | captopril | CAPTOPRIL | 17473847 |