Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/ENO1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ENO1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ENO1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ENO1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ENO1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ENO1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ENO1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ENO1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ENO1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ENO1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ENO1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ENO1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ENO1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442824 | Stomach | GC | small molecule catabolic process | 40/1159 | 376/18723 | 5.92e-04 | 8.09e-03 | 40 |
GO:00016666 | Stomach | GC | response to hypoxia | 34/1159 | 307/18723 | 7.34e-04 | 9.54e-03 | 34 |
GO:00704826 | Stomach | GC | response to oxygen levels | 37/1159 | 347/18723 | 8.94e-04 | 1.10e-02 | 37 |
GO:00067344 | Stomach | GC | NADH metabolic process | 7/1159 | 29/18723 | 1.60e-03 | 1.70e-02 | 7 |
GO:00060064 | Stomach | GC | glucose metabolic process | 23/1159 | 196/18723 | 2.39e-03 | 2.29e-02 | 23 |
GO:00096154 | Stomach | GC | response to virus | 37/1159 | 367/18723 | 2.41e-03 | 2.30e-02 | 37 |
GO:00362945 | Stomach | GC | cellular response to decreased oxygen levels | 19/1159 | 161/18723 | 5.13e-03 | 4.05e-02 | 19 |
GO:00459262 | Stomach | GC | negative regulation of growth | 26/1159 | 249/18723 | 6.36e-03 | 4.74e-02 | 26 |
GO:004603411 | Stomach | CAG with IM | ATP metabolic process | 72/1050 | 277/18723 | 6.46e-29 | 1.72e-25 | 72 |
GO:000609111 | Stomach | CAG with IM | generation of precursor metabolites and energy | 86/1050 | 490/18723 | 1.45e-21 | 1.93e-18 | 86 |
GO:000914411 | Stomach | CAG with IM | purine nucleoside triphosphate metabolic process | 25/1050 | 88/18723 | 8.00e-12 | 2.40e-09 | 25 |
GO:000920611 | Stomach | CAG with IM | purine ribonucleoside triphosphate biosynthetic process | 22/1050 | 68/18723 | 8.10e-12 | 2.40e-09 | 22 |
GO:000920511 | Stomach | CAG with IM | purine ribonucleoside triphosphate metabolic process | 24/1050 | 82/18723 | 1.03e-11 | 2.76e-09 | 24 |
GO:000914511 | Stomach | CAG with IM | purine nucleoside triphosphate biosynthetic process | 22/1050 | 69/18723 | 1.13e-11 | 2.86e-09 | 22 |
GO:000675411 | Stomach | CAG with IM | ATP biosynthetic process | 20/1050 | 57/18723 | 1.32e-11 | 3.14e-09 | 20 |
GO:000920111 | Stomach | CAG with IM | ribonucleoside triphosphate biosynthetic process | 22/1050 | 74/18723 | 5.34e-11 | 1.09e-08 | 22 |
GO:000919911 | Stomach | CAG with IM | ribonucleoside triphosphate metabolic process | 24/1050 | 89/18723 | 7.02e-11 | 1.34e-08 | 24 |
GO:000914211 | Stomach | CAG with IM | nucleoside triphosphate biosynthetic process | 23/1050 | 85/18723 | 1.62e-10 | 2.98e-08 | 23 |
GO:200123311 | Stomach | CAG with IM | regulation of apoptotic signaling pathway | 52/1050 | 356/18723 | 2.17e-10 | 3.85e-08 | 52 |
GO:000914111 | Stomach | CAG with IM | nucleoside triphosphate metabolic process | 26/1050 | 112/18723 | 4.23e-10 | 6.83e-08 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENO1 | SNV | Missense_Mutation | | c.689C>A | p.Ala230Asp | p.A230D | P06733 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.988) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ENO1 | SNV | Missense_Mutation | rs750183904 | c.466N>A | p.Gly156Ser | p.G156S | P06733 | protein_coding | deleterious_low_confidence(0.05) | possibly_damaging(0.594) | TCGA-E9-A22H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ENO1 | insertion | Nonsense_Mutation | novel | c.945_946insATTTTATTTTTATTTTTTTGAGAGGGATCTCACTC | p.Val316IlefsTer7 | p.V316Ifs*7 | P06733 | protein_coding | | | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
ENO1 | SNV | Missense_Mutation | | c.1240G>A | p.Glu414Lys | p.E414K | P06733 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.984) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | | SD |
ENO1 | SNV | Missense_Mutation | rs527568599 | c.452N>G | p.Asn151Ser | p.N151S | P06733 | protein_coding | deleterious_low_confidence(0.05) | benign(0.083) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENO1 | SNV | Missense_Mutation | novel | c.628N>A | p.Glu210Lys | p.E210K | P06733 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.796) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENO1 | insertion | Frame_Shift_Ins | novel | c.1081dupC | p.Gln361ProfsTer17 | p.Q361Pfs*17 | P06733 | protein_coding | | | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENO1 | SNV | Missense_Mutation | novel | c.97G>C | p.Ala33Pro | p.A33P | P06733 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
ENO1 | SNV | Missense_Mutation | | c.223C>G | p.Pro75Ala | p.P75A | P06733 | protein_coding | deleterious_low_confidence(0.03) | benign(0.046) | TCGA-AD-6965-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
ENO1 | SNV | Missense_Mutation | | c.1286G>A | p.Arg429Lys | p.R429K | P06733 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.861) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |