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Gene: HSPB1 |
Gene summary for HSPB1 |
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Gene information | Species | Human | Gene symbol | HSPB1 | Gene ID | 3315 |
Gene name | heat shock protein family B (small) member 1 | |
Gene Alias | CMT2F | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P04792 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3315 | HSPB1 | GSM4909280 | Human | Breast | Precancer | 7.43e-04 | 4.23e-01 | 0.0305 |
3315 | HSPB1 | GSM4909281 | Human | Breast | IDC | 1.58e-04 | 1.35e-01 | 0.21 |
3315 | HSPB1 | GSM4909282 | Human | Breast | IDC | 3.02e-72 | 9.71e-01 | -0.0288 |
3315 | HSPB1 | GSM4909285 | Human | Breast | IDC | 1.58e-11 | 2.57e-01 | 0.21 |
3315 | HSPB1 | GSM4909286 | Human | Breast | IDC | 1.06e-15 | -7.60e-01 | 0.1081 |
3315 | HSPB1 | GSM4909288 | Human | Breast | IDC | 4.70e-02 | -4.58e-01 | 0.0988 |
3315 | HSPB1 | GSM4909290 | Human | Breast | IDC | 2.40e-08 | -6.55e-01 | 0.2096 |
3315 | HSPB1 | GSM4909291 | Human | Breast | IDC | 2.59e-77 | 1.30e+00 | 0.1753 |
3315 | HSPB1 | GSM4909293 | Human | Breast | IDC | 1.22e-04 | 2.69e-02 | 0.1581 |
3315 | HSPB1 | GSM4909296 | Human | Breast | IDC | 4.74e-57 | 9.63e-01 | 0.1524 |
3315 | HSPB1 | GSM4909297 | Human | Breast | IDC | 5.80e-12 | 4.31e-01 | 0.1517 |
3315 | HSPB1 | GSM4909298 | Human | Breast | IDC | 4.33e-10 | 3.05e-01 | 0.1551 |
3315 | HSPB1 | GSM4909301 | Human | Breast | IDC | 2.70e-110 | 1.16e+00 | 0.1577 |
3315 | HSPB1 | GSM4909302 | Human | Breast | IDC | 4.70e-20 | 6.65e-01 | 0.1545 |
3315 | HSPB1 | GSM4909304 | Human | Breast | IDC | 2.30e-59 | 8.19e-01 | 0.1636 |
3315 | HSPB1 | GSM4909306 | Human | Breast | IDC | 3.03e-49 | 7.89e-01 | 0.1564 |
3315 | HSPB1 | GSM4909307 | Human | Breast | IDC | 2.44e-42 | 7.99e-01 | 0.1569 |
3315 | HSPB1 | GSM4909308 | Human | Breast | IDC | 2.68e-71 | 1.01e+00 | 0.158 |
3315 | HSPB1 | GSM4909309 | Human | Breast | IDC | 2.02e-03 | 4.21e-01 | 0.0483 |
3315 | HSPB1 | GSM4909311 | Human | Breast | IDC | 1.10e-18 | 3.19e-01 | 0.1534 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006413111 | Skin | cSCC | translational initiation | 84/4864 | 118/18723 | 9.12e-25 | 2.29e-22 | 84 |
GO:009719329 | Skin | cSCC | intrinsic apoptotic signaling pathway | 150/4864 | 288/18723 | 1.76e-21 | 3.34e-19 | 150 |
GO:200123329 | Skin | cSCC | regulation of apoptotic signaling pathway | 173/4864 | 356/18723 | 2.25e-20 | 3.44e-18 | 173 |
GO:200124229 | Skin | cSCC | regulation of intrinsic apoptotic signaling pathway | 96/4864 | 164/18723 | 9.88e-19 | 1.32e-16 | 96 |
GO:0035966112 | Skin | cSCC | response to topologically incorrect protein | 90/4864 | 159/18723 | 2.26e-16 | 2.12e-14 | 90 |
GO:000644619 | Skin | cSCC | regulation of translational initiation | 54/4864 | 79/18723 | 3.38e-15 | 2.72e-13 | 54 |
GO:0006986112 | Skin | cSCC | response to unfolded protein | 78/4864 | 137/18723 | 1.44e-14 | 1.03e-12 | 78 |
GO:0061077111 | Skin | cSCC | chaperone-mediated protein folding | 46/4864 | 67/18723 | 2.93e-13 | 1.75e-11 | 46 |
GO:000697929 | Skin | cSCC | response to oxidative stress | 184/4864 | 446/18723 | 8.57e-13 | 4.89e-11 | 184 |
GO:000961522 | Skin | cSCC | response to virus | 152/4864 | 367/18723 | 5.88e-11 | 2.75e-09 | 152 |
GO:200123429 | Skin | cSCC | negative regulation of apoptotic signaling pathway | 101/4864 | 224/18723 | 4.17e-10 | 1.70e-08 | 101 |
GO:006219729 | Skin | cSCC | cellular response to chemical stress | 138/4864 | 337/18723 | 1.10e-09 | 4.23e-08 | 138 |
GO:200124327 | Skin | cSCC | negative regulation of intrinsic apoptotic signaling pathway | 53/4864 | 98/18723 | 2.91e-09 | 1.02e-07 | 53 |
GO:000724925 | Skin | cSCC | I-kappaB kinase/NF-kappaB signaling | 116/4864 | 281/18723 | 1.33e-08 | 4.08e-07 | 116 |
GO:004312225 | Skin | cSCC | regulation of I-kappaB kinase/NF-kappaB signaling | 105/4864 | 249/18723 | 1.70e-08 | 5.09e-07 | 105 |
GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
GO:001050619 | Skin | cSCC | regulation of autophagy | 127/4864 | 317/18723 | 2.36e-08 | 6.71e-07 | 127 |
GO:003459928 | Skin | cSCC | cellular response to oxidative stress | 117/4864 | 288/18723 | 3.37e-08 | 8.95e-07 | 117 |
GO:0008631111 | Skin | cSCC | intrinsic apoptotic signaling pathway in response to oxidative stress | 29/4864 | 45/18723 | 6.53e-08 | 1.64e-06 | 29 |
GO:004593628 | Skin | cSCC | negative regulation of phosphate metabolic process | 160/4864 | 441/18723 | 8.89e-07 | 1.63e-05 | 160 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051465 | Cervix | CC | Amoebiasis | 29/1267 | 102/8465 | 3.31e-04 | 1.70e-03 | 1.01e-03 | 29 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0514612 | Cervix | CC | Amoebiasis | 29/1267 | 102/8465 | 3.31e-04 | 1.70e-03 | 1.01e-03 | 29 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa040102 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa040103 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa051466 | Endometrium | AEH | Amoebiasis | 29/1197 | 102/8465 | 1.22e-04 | 1.10e-03 | 8.06e-04 | 29 |
hsa0514613 | Endometrium | AEH | Amoebiasis | 29/1197 | 102/8465 | 1.22e-04 | 1.10e-03 | 8.06e-04 | 29 |
hsa0514622 | Endometrium | EEC | Amoebiasis | 28/1237 | 102/8465 | 5.23e-04 | 3.83e-03 | 2.85e-03 | 28 |
hsa0514632 | Endometrium | EEC | Amoebiasis | 28/1237 | 102/8465 | 5.23e-04 | 3.83e-03 | 2.85e-03 | 28 |
hsa040108 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa051464 | Lung | IAC | Amoebiasis | 23/1053 | 102/8465 | 2.99e-03 | 1.53e-02 | 1.02e-02 | 23 |
hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0514611 | Lung | IAC | Amoebiasis | 23/1053 | 102/8465 | 2.99e-03 | 1.53e-02 | 1.02e-02 | 23 |
hsa0401021 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa0514621 | Lung | AIS | Amoebiasis | 20/961 | 102/8465 | 9.86e-03 | 4.20e-02 | 2.69e-02 | 20 |
hsa0401031 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa0514631 | Lung | AIS | Amoebiasis | 20/961 | 102/8465 | 9.86e-03 | 4.20e-02 | 2.69e-02 | 20 |
hsa040104 | Lung | AAH | MAPK signaling pathway | 27/348 | 302/8465 | 1.13e-04 | 6.32e-03 | 5.08e-03 | 27 |
hsa040105 | Lung | AAH | MAPK signaling pathway | 27/348 | 302/8465 | 1.13e-04 | 6.32e-03 | 5.08e-03 | 27 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPB1 | SNV | Missense_Mutation | novel | c.503N>A | p.Pro168His | p.P168H | P04792 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
HSPB1 | SNV | Missense_Mutation | novel | c.513G>T | p.Lys171Asn | p.K171N | P04792 | protein_coding | tolerated(0.06) | benign(0.223) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HSPB1 | SNV | Missense_Mutation | novel | c.574N>T | p.Gly192Trp | p.G192W | P04792 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HSPB1 | SNV | Missense_Mutation | novel | c.413N>G | p.Phe138Cys | p.F138C | P04792 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-NC-A5HR-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
HSPB1 | insertion | Frame_Shift_Ins | rs747325717 | c.432_433insC | p.Gly147ArgfsTer14 | p.G147Rfs*14 | P04792 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3315 | HSPB1 | DRUGGABLE GENOME | DIFFERENTIATION AGENTS | 8065161 | ||
3315 | HSPB1 | DRUGGABLE GENOME | TRIAMTERENE | TRIAMTERENE | ||
3315 | HSPB1 | DRUGGABLE GENOME | UREA | UREA | 9094264 | |
3315 | HSPB1 | DRUGGABLE GENOME | QUERCETIN | QUERCETIN | 19296652 | |
3315 | HSPB1 | DRUGGABLE GENOME | TYROSINE KINASE INHIBITOR | 8875961 | ||
3315 | HSPB1 | DRUGGABLE GENOME | inhibitor | OGX-427 | APATORSEN | |
3315 | HSPB1 | DRUGGABLE GENOME | PHENANTHROLINE | PHENANTHROLINE | ||
3315 | HSPB1 | DRUGGABLE GENOME | DIFFERENTIATION INDUCER | 7500647 | ||
3315 | HSPB1 | DRUGGABLE GENOME | DICARBONODITHIOIMIDIC DIAMIDE | DICARBONODITHIOIMIDIC DIAMIDE | ||
3315 | HSPB1 | DRUGGABLE GENOME | BENZENETHIOL | BENZENETHIOL |
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