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Gene: CD2 |
Gene summary for CD2 |
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Gene information | Species | Human | Gene symbol | CD2 | Gene ID | 914 |
Gene name | CD2 molecule | |
Gene Alias | LFA-2 | |
Cytomap | 1p13.1 | |
Gene Type | protein-coding | GO ID | GO:0001766 | UniProtAcc | P06729 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
914 | CD2 | GSM4909317 | Human | Breast | IDC | 5.23e-05 | 1.70e-01 | 0.1355 |
914 | CD2 | M1 | Human | Breast | IDC | 3.01e-40 | 8.10e-01 | 0.1577 |
914 | CD2 | P1 | Human | Breast | IDC | 4.16e-12 | 6.08e-01 | 0.1527 |
914 | CD2 | LZE4T | Human | Esophagus | ESCC | 4.60e-14 | 7.29e-01 | 0.0811 |
914 | CD2 | LZE7T | Human | Esophagus | ESCC | 2.24e-10 | 7.96e-01 | 0.0667 |
914 | CD2 | LZE8T | Human | Esophagus | ESCC | 3.62e-04 | 4.38e-01 | 0.067 |
914 | CD2 | LZE22D1 | Human | Esophagus | HGIN | 3.59e-02 | 2.59e-01 | 0.0595 |
914 | CD2 | LZE24T | Human | Esophagus | ESCC | 4.59e-03 | 1.77e-01 | 0.0596 |
914 | CD2 | LZE6T | Human | Esophagus | ESCC | 3.15e-24 | 1.50e+00 | 0.0845 |
914 | CD2 | C21 | Human | Oral cavity | OSCC | 1.93e-15 | 6.64e-01 | 0.2678 |
914 | CD2 | C30 | Human | Oral cavity | OSCC | 2.02e-06 | 2.12e-01 | 0.3055 |
914 | CD2 | C38 | Human | Oral cavity | OSCC | 6.23e-08 | 1.25e+00 | 0.172 |
914 | CD2 | C46 | Human | Oral cavity | OSCC | 5.10e-05 | 2.47e-01 | 0.1673 |
914 | CD2 | C51 | Human | Oral cavity | OSCC | 1.67e-03 | 1.61e-01 | 0.2674 |
914 | CD2 | C57 | Human | Oral cavity | OSCC | 8.29e-04 | 1.33e-01 | 0.1679 |
914 | CD2 | C06 | Human | Oral cavity | OSCC | 2.51e-03 | 9.88e-01 | 0.2699 |
914 | CD2 | C07 | Human | Oral cavity | OSCC | 1.79e-03 | 3.19e-01 | 0.2491 |
914 | CD2 | LN22 | Human | Oral cavity | OSCC | 2.16e-04 | 7.29e-01 | 0.1733 |
914 | CD2 | LN38 | Human | Oral cavity | OSCC | 2.02e-02 | 6.93e-01 | 0.168 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512517 | Oral cavity | EOLP | positive regulation of lymphocyte activation | 72/2218 | 362/18723 | 6.21e-06 | 1.22e-04 | 72 |
GO:007066112 | Oral cavity | EOLP | leukocyte proliferation | 65/2218 | 318/18723 | 6.86e-06 | 1.33e-04 | 65 |
GO:190303915 | Oral cavity | EOLP | positive regulation of leukocyte cell-cell adhesion | 52/2218 | 239/18723 | 9.14e-06 | 1.70e-04 | 52 |
GO:004586017 | Oral cavity | EOLP | positive regulation of protein kinase activity | 74/2218 | 386/18723 | 1.78e-05 | 2.89e-04 | 74 |
GO:007066310 | Oral cavity | EOLP | regulation of leukocyte proliferation | 52/2218 | 245/18723 | 1.89e-05 | 3.01e-04 | 52 |
GO:00508677 | Oral cavity | EOLP | positive regulation of cell activation | 79/2218 | 420/18723 | 1.91e-05 | 3.02e-04 | 79 |
GO:00026968 | Oral cavity | EOLP | positive regulation of leukocyte activation | 77/2218 | 409/18723 | 2.34e-05 | 3.52e-04 | 77 |
GO:005087014 | Oral cavity | EOLP | positive regulation of T cell activation | 47/2218 | 216/18723 | 2.40e-05 | 3.58e-04 | 47 |
GO:004209817 | Oral cavity | EOLP | T cell proliferation | 44/2218 | 199/18723 | 2.86e-05 | 4.14e-04 | 44 |
GO:004665112 | Oral cavity | EOLP | lymphocyte proliferation | 58/2218 | 288/18723 | 3.29e-05 | 4.63e-04 | 58 |
GO:002240918 | Oral cavity | EOLP | positive regulation of cell-cell adhesion | 57/2218 | 284/18723 | 4.23e-05 | 5.77e-04 | 57 |
GO:00457308 | Oral cavity | EOLP | respiratory burst | 14/2218 | 37/18723 | 4.41e-05 | 5.93e-04 | 14 |
GO:00329436 | Oral cavity | EOLP | mononuclear cell proliferation | 58/2218 | 291/18723 | 4.48e-05 | 5.99e-04 | 58 |
GO:004825915 | Oral cavity | EOLP | regulation of receptor-mediated endocytosis | 28/2218 | 110/18723 | 6.12e-05 | 7.68e-04 | 28 |
GO:00506706 | Oral cavity | EOLP | regulation of lymphocyte proliferation | 47/2218 | 225/18723 | 7.03e-05 | 8.67e-04 | 47 |
GO:004340521 | Oral cavity | EOLP | regulation of MAP kinase activity | 39/2218 | 177/18723 | 8.57e-05 | 1.02e-03 | 39 |
GO:00329445 | Oral cavity | EOLP | regulation of mononuclear cell proliferation | 47/2218 | 227/18723 | 8.81e-05 | 1.04e-03 | 47 |
GO:000223724 | Oral cavity | EOLP | response to molecule of bacterial origin | 67/2218 | 363/18723 | 1.42e-04 | 1.53e-03 | 67 |
GO:003367419 | Oral cavity | EOLP | positive regulation of kinase activity | 82/2218 | 467/18723 | 1.58e-04 | 1.68e-03 | 82 |
GO:004212910 | Oral cavity | EOLP | regulation of T cell proliferation | 36/2218 | 171/18723 | 4.01e-04 | 3.58e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Breast | ADJ |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Breast | ADJ |
PVR | CD226 | PVR_CD226 | PVR | Breast | ADJ |
CD70 | CD27 | CD70_CD27 | CD70 | Breast | ADJ |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Breast | DCIS |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Breast | DCIS |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Breast | DCIS |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Breast | IDC |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | ADJ |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Cervix | ADJ |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Cervix | ADJ |
CD70 | CD27 | CD70_CD27 | CD70 | Cervix | ADJ |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | CC |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Cervix | CC |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Cervix | CC |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | Healthy |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | Precancer |
PTPRC | CD22 | PTPRC_CD22 | CD45 | CRC | AD |
CD48 | CD244 | CD48_CD244A | CD48 | CRC | AD |
PTPRC | CD22 | PTPRC_CD22 | CD45 | CRC | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD2 | SNV | Missense_Mutation | c.205N>A | p.Ala69Thr | p.A69T | P06729 | protein_coding | deleterious(0.04) | probably_damaging(0.929) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD2 | SNV | Missense_Mutation | c.150N>C | p.Met50Ile | p.M50I | P06729 | protein_coding | tolerated(0.08) | benign(0.196) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CD2 | SNV | Missense_Mutation | c.776A>C | p.Glu259Ala | p.E259A | P06729 | protein_coding | tolerated(0.06) | possibly_damaging(0.669) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CD2 | SNV | Missense_Mutation | novel | c.420C>G | p.Ile140Met | p.I140M | P06729 | protein_coding | tolerated(0.11) | possibly_damaging(0.687) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CD2 | SNV | Missense_Mutation | c.141T>G | p.Ser47Arg | p.S47R | P06729 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CD2 | SNV | Missense_Mutation | rs769894316 | c.595G>A | p.Glu199Lys | p.E199K | P06729 | protein_coding | tolerated(0.84) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CD2 | SNV | Missense_Mutation | c.67N>T | p.Val23Phe | p.V23F | P06729 | protein_coding | tolerated(0.06) | benign(0.086) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CD2 | SNV | Missense_Mutation | c.166N>A | p.Asp56Asn | p.D56N | P06729 | protein_coding | tolerated(0.09) | probably_damaging(0.927) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CD2 | SNV | Missense_Mutation | c.881N>T | p.Ser294Ile | p.S294I | P06729 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CD2 | SNV | Missense_Mutation | novel | c.320N>C | p.Val107Ala | p.V107A | P06729 | protein_coding | deleterious(0.05) | possibly_damaging(0.811) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | 178103393 | ALEFACEPT | |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ALEFACEPT | ALEFACEPT | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | CHEMBL2108742 | SIPLIZUMAB | |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ZNCL2 | 8131214 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | SMS 201-995 | 7628916 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | CHEMBL1201571 | ALEFACEPT | |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | Siplizumab | SIPLIZUMAB | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | TUMOR NECROSIS FACTOR | 1359970 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | COBALT | 8131214 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ALEFACEPT | ALEFACEPT |
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