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Gene: DDX3X |
Gene summary for DDX3X |
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Gene information | Species | Human | Gene symbol | DDX3X | Gene ID | 1654 |
Gene name | DEAD-box helicase 3 X-linked | |
Gene Alias | CAP-Rf | |
Cytomap | Xp11.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O00571 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1654 | DDX3X | GSM4909282 | Human | Breast | IDC | 1.60e-08 | -4.66e-01 | -0.0288 |
1654 | DDX3X | GSM4909285 | Human | Breast | IDC | 2.26e-03 | -3.03e-01 | 0.21 |
1654 | DDX3X | GSM4909286 | Human | Breast | IDC | 1.38e-07 | -2.68e-01 | 0.1081 |
1654 | DDX3X | GSM4909293 | Human | Breast | IDC | 7.56e-05 | 2.20e-01 | 0.1581 |
1654 | DDX3X | GSM4909294 | Human | Breast | IDC | 3.00e-05 | -2.81e-01 | 0.2022 |
1654 | DDX3X | GSM4909296 | Human | Breast | IDC | 1.49e-15 | -4.01e-01 | 0.1524 |
1654 | DDX3X | GSM4909297 | Human | Breast | IDC | 1.39e-14 | -1.92e-01 | 0.1517 |
1654 | DDX3X | GSM4909301 | Human | Breast | IDC | 1.01e-02 | -3.16e-01 | 0.1577 |
1654 | DDX3X | GSM4909311 | Human | Breast | IDC | 5.10e-37 | -5.06e-01 | 0.1534 |
1654 | DDX3X | GSM4909312 | Human | Breast | IDC | 9.85e-13 | -2.67e-01 | 0.1552 |
1654 | DDX3X | GSM4909313 | Human | Breast | IDC | 1.09e-04 | 1.49e-01 | 0.0391 |
1654 | DDX3X | GSM4909317 | Human | Breast | IDC | 4.79e-07 | 3.61e-01 | 0.1355 |
1654 | DDX3X | GSM4909319 | Human | Breast | IDC | 8.78e-39 | -6.57e-01 | 0.1563 |
1654 | DDX3X | GSM4909320 | Human | Breast | IDC | 1.57e-05 | -5.09e-01 | 0.1575 |
1654 | DDX3X | GSM4909321 | Human | Breast | IDC | 1.04e-15 | -2.05e-01 | 0.1559 |
1654 | DDX3X | brca1 | Human | Breast | Precancer | 6.61e-04 | -3.33e-01 | -0.0338 |
1654 | DDX3X | brca10 | Human | Breast | Precancer | 4.37e-07 | -4.79e-01 | -0.0029 |
1654 | DDX3X | NCCBC14 | Human | Breast | DCIS | 3.00e-06 | -1.85e-01 | 0.2021 |
1654 | DDX3X | NCCBC5 | Human | Breast | DCIS | 5.30e-12 | -3.22e-01 | 0.2046 |
1654 | DDX3X | P1 | Human | Breast | IDC | 1.12e-23 | 2.15e-02 | 0.1527 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:019873818 | Skin | AK | cell-cell signaling by wnt | 98/1910 | 446/18723 | 1.26e-13 | 3.72e-11 | 98 |
GO:004225427 | Skin | AK | ribosome biogenesis | 73/1910 | 299/18723 | 8.44e-13 | 2.08e-10 | 73 |
GO:190332028 | Skin | AK | regulation of protein modification by small protein conjugation or removal | 62/1910 | 242/18723 | 4.90e-12 | 1.04e-09 | 62 |
GO:001905828 | Skin | AK | viral life cycle | 74/1910 | 317/18723 | 6.21e-12 | 1.27e-09 | 74 |
GO:003011118 | Skin | AK | regulation of Wnt signaling pathway | 73/1910 | 328/18723 | 9.27e-11 | 1.52e-08 | 73 |
GO:003139628 | Skin | AK | regulation of protein ubiquitination | 54/1910 | 210/18723 | 9.94e-11 | 1.55e-08 | 54 |
GO:004225528 | Skin | AK | ribosome assembly | 25/1910 | 61/18723 | 3.23e-10 | 4.15e-08 | 25 |
GO:200123428 | Skin | AK | negative regulation of apoptotic signaling pathway | 55/1910 | 224/18723 | 4.38e-10 | 5.24e-08 | 55 |
GO:006007017 | Skin | AK | canonical Wnt signaling pathway | 67/1910 | 303/18723 | 7.30e-10 | 7.45e-08 | 67 |
GO:001604920 | Skin | AK | cell growth | 93/1910 | 482/18723 | 9.55e-10 | 9.42e-08 | 93 |
GO:003425025 | Skin | AK | positive regulation of cellular amide metabolic process | 43/1910 | 162/18723 | 2.77e-09 | 2.40e-07 | 43 |
GO:000641326 | Skin | AK | translational initiation | 35/1910 | 118/18723 | 3.54e-09 | 2.87e-07 | 35 |
GO:004477210 | Skin | AK | mitotic cell cycle phase transition | 83/1910 | 424/18723 | 3.81e-09 | 3.05e-07 | 83 |
GO:005254727 | Skin | AK | regulation of peptidase activity | 88/1910 | 461/18723 | 4.65e-09 | 3.44e-07 | 88 |
GO:200124326 | Skin | AK | negative regulation of intrinsic apoptotic signaling pathway | 31/1910 | 98/18723 | 4.97e-09 | 3.63e-07 | 31 |
GO:004586127 | Skin | AK | negative regulation of proteolysis | 72/1910 | 351/18723 | 5.40e-09 | 3.90e-07 | 72 |
GO:000734616 | Skin | AK | regulation of mitotic cell cycle | 87/1910 | 457/18723 | 6.50e-09 | 4.47e-07 | 87 |
GO:006082818 | Skin | AK | regulation of canonical Wnt signaling pathway | 57/1910 | 253/18723 | 6.57e-09 | 4.47e-07 | 57 |
GO:004586228 | Skin | AK | positive regulation of proteolysis | 74/1910 | 372/18723 | 1.32e-08 | 8.20e-07 | 74 |
GO:00000828 | Skin | AK | G1/S transition of mitotic cell cycle | 50/1910 | 214/18723 | 1.57e-08 | 9.40e-07 | 50 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0520312 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0520341 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa052035 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa051619 | Esophagus | ESCC | Hepatitis B | 108/4205 | 162/8465 | 7.68e-06 | 4.15e-05 | 2.12e-05 | 108 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0516114 | Esophagus | ESCC | Hepatitis B | 108/4205 | 162/8465 | 7.68e-06 | 4.15e-05 | 2.12e-05 | 108 |
hsa05203 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052031 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa051612 | Liver | HCC | Hepatitis B | 91/4020 | 162/8465 | 1.56e-02 | 3.76e-02 | 2.09e-02 | 91 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516111 | Liver | HCC | Hepatitis B | 91/4020 | 162/8465 | 1.56e-02 | 3.76e-02 | 2.09e-02 | 91 |
hsa051618 | Oral cavity | OSCC | Hepatitis B | 103/3704 | 162/8465 | 2.34e-07 | 1.51e-06 | 7.69e-07 | 103 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX3X | SNV | Missense_Mutation | c.1675N>A | p.Leu559Ile | p.L559I | O00571 | protein_coding | tolerated(0.31) | benign(0.182) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DDX3X | SNV | Missense_Mutation | novel | c.878C>A | p.Ser293Tyr | p.S293Y | O00571 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX3X | SNV | Missense_Mutation | c.425N>T | p.Pro142Leu | p.P142L | O00571 | protein_coding | tolerated(0.11) | benign(0.179) | TCGA-AO-A03L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
DDX3X | SNV | Missense_Mutation | novel | c.536N>C | p.Ile179Thr | p.I179T | O00571 | protein_coding | deleterious(0.03) | benign(0.336) | TCGA-B6-A402-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PD |
DDX3X | SNV | Missense_Mutation | c.203C>T | p.Ala68Val | p.A68V | O00571 | protein_coding | tolerated(0.15) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
DDX3X | SNV | Missense_Mutation | c.1907N>A | p.Gly636Glu | p.G636E | O00571 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DDX3X | SNV | Missense_Mutation | c.81N>C | p.Gln27His | p.Q27H | O00571 | protein_coding | deleterious(0.04) | possibly_damaging(0.462) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
DDX3X | SNV | Missense_Mutation | novel | c.1321G>C | p.Asp441His | p.D441H | O00571 | protein_coding | deleterious(0.02) | possibly_damaging(0.749) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DDX3X | SNV | Missense_Mutation | novel | c.1873N>A | p.Gly625Arg | p.G625R | O00571 | protein_coding | deleterious(0.04) | benign(0.009) | TCGA-E2-A1B0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
DDX3X | SNV | Missense_Mutation | novel | c.577N>A | p.Gly193Arg | p.G193R | O00571 | protein_coding | tolerated(0.4) | benign(0.272) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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