Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ARC_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ARC_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ARC_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ARC_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000828612 | Lung | AIS | insulin receptor signaling pathway | 25/1849 | 116/18723 | 1.39e-04 | 3.05e-03 | 25 |
GO:190336312 | Lung | AIS | negative regulation of cellular protein catabolic process | 18/1849 | 75/18723 | 2.89e-04 | 5.40e-03 | 18 |
GO:00165751 | Lung | AIS | histone deacetylation | 19/1849 | 82/18723 | 3.23e-04 | 5.84e-03 | 19 |
GO:004586113 | Lung | AIS | negative regulation of proteolysis | 55/1849 | 351/18723 | 3.87e-04 | 6.72e-03 | 55 |
GO:000632512 | Lung | AIS | chromatin organization | 62/1849 | 409/18723 | 4.24e-04 | 7.29e-03 | 62 |
GO:003560111 | Lung | AIS | protein deacylation | 23/1849 | 112/18723 | 5.25e-04 | 8.42e-03 | 23 |
GO:00987321 | Lung | AIS | macromolecule deacylation | 23/1849 | 116/18723 | 8.77e-04 | 1.19e-02 | 23 |
GO:190305112 | Lung | AIS | negative regulation of proteolysis involved in cellular protein catabolic process | 15/1849 | 64/18723 | 1.17e-03 | 1.49e-02 | 15 |
GO:004873213 | Lung | AIS | gland development | 63/1849 | 436/18723 | 1.34e-03 | 1.66e-02 | 63 |
GO:0030850 | Lung | AIS | prostate gland development | 11/1849 | 45/18723 | 3.63e-03 | 3.42e-02 | 11 |
GO:20000598 | Lung | AIS | negative regulation of ubiquitin-dependent protein catabolic process | 11/1849 | 48/18723 | 6.14e-03 | 4.98e-02 | 11 |
GO:190336223 | Lung | AAH | regulation of cellular protein catabolic process | 24/613 | 255/18723 | 3.74e-06 | 1.07e-03 | 24 |
GO:004217623 | Lung | AAH | regulation of protein catabolic process | 29/613 | 391/18723 | 3.92e-05 | 4.60e-03 | 29 |
GO:200005823 | Lung | AAH | regulation of ubiquitin-dependent protein catabolic process | 16/613 | 164/18723 | 9.96e-05 | 7.08e-03 | 16 |
GO:000828621 | Lung | AAH | insulin receptor signaling pathway | 13/613 | 116/18723 | 1.10e-04 | 7.39e-03 | 13 |
GO:190305023 | Lung | AAH | regulation of proteolysis involved in cellular protein catabolic process | 19/613 | 221/18723 | 1.28e-04 | 8.23e-03 | 19 |
GO:190165322 | Lung | AAH | cellular response to peptide | 24/613 | 359/18723 | 8.02e-04 | 2.72e-02 | 24 |
GO:003133023 | Lung | AAH | negative regulation of cellular catabolic process | 19/613 | 262/18723 | 1.07e-03 | 3.21e-02 | 19 |
GO:003286822 | Lung | AAH | response to insulin | 19/613 | 264/18723 | 1.17e-03 | 3.33e-02 | 19 |
GO:007137522 | Lung | AAH | cellular response to peptide hormone stimulus | 20/613 | 290/18723 | 1.47e-03 | 3.76e-02 | 20 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARC | SNV | Missense_Mutation | | c.373N>T | p.Arg125Cys | p.R125C | Q7LC44 | protein_coding | deleterious_low_confidence(0) | benign(0.432) | TCGA-A1-A0SG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
ARC | SNV | Missense_Mutation | rs766434970 | c.1144N>A | p.Ala382Thr | p.A382T | Q7LC44 | protein_coding | deleterious_low_confidence(0.01) | benign(0.026) | TCGA-LL-A7T0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARC | SNV | Missense_Mutation | | c.932N>T | p.Thr311Met | p.T311M | Q7LC44 | protein_coding | deleterious(0.05) | probably_damaging(0.933) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARC | SNV | Missense_Mutation | | c.686G>A | p.Arg229Gln | p.R229Q | Q7LC44 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-AA-3494-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PR |
ARC | SNV | Missense_Mutation | novel | c.365N>A | p.Arg122His | p.R122H | Q7LC44 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARC | SNV | Missense_Mutation | rs771620864 | c.307G>A | p.Ala103Thr | p.A103T | Q7LC44 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.649) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ARC | SNV | Missense_Mutation | | c.1043N>G | p.Leu348Arg | p.L348R | Q7LC44 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARC | SNV | Missense_Mutation | rs771620864 | c.307N>A | p.Ala103Thr | p.A103T | Q7LC44 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.649) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARC | SNV | Missense_Mutation | rs774341447 | c.332N>A | p.Arg111His | p.R111H | Q7LC44 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-CM-6165-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARC | SNV | Missense_Mutation | | c.1111N>T | p.Pro371Ser | p.P371S | Q7LC44 | protein_coding | deleterious_low_confidence(0.02) | benign(0.001) | TCGA-D5-6929-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+ | SD |