Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009887618 | Thyroid | PTC | vesicle-mediated transport to the plasma membrane | 74/5968 | 136/18723 | 4.20e-08 | 9.08e-07 | 74 |
GO:0010975110 | Thyroid | PTC | regulation of neuron projection development | 194/5968 | 445/18723 | 1.05e-07 | 2.08e-06 | 194 |
GO:003083326 | Thyroid | PTC | regulation of actin filament polymerization | 88/5968 | 172/18723 | 1.07e-07 | 2.11e-06 | 88 |
GO:190382815 | Thyroid | PTC | negative regulation of cellular protein localization | 64/5968 | 117/18723 | 2.61e-07 | 4.52e-06 | 64 |
GO:001635819 | Thyroid | PTC | dendrite development | 115/5968 | 243/18723 | 3.16e-07 | 5.35e-06 | 115 |
GO:1903076112 | Thyroid | PTC | regulation of protein localization to plasma membrane | 58/5968 | 104/18723 | 3.91e-07 | 6.51e-06 | 58 |
GO:0120032111 | Thyroid | PTC | regulation of plasma membrane bounded cell projection assembly | 92/5968 | 186/18723 | 4.12e-07 | 6.83e-06 | 92 |
GO:003001020 | Thyroid | PTC | establishment of cell polarity | 74/5968 | 143/18723 | 6.05e-07 | 9.63e-06 | 74 |
GO:006049120 | Thyroid | PTC | regulation of cell projection assembly | 92/5968 | 188/18723 | 7.55e-07 | 1.18e-05 | 92 |
GO:0030865110 | Thyroid | PTC | cortical cytoskeleton organization | 38/5968 | 61/18723 | 9.77e-07 | 1.46e-05 | 38 |
GO:0034329111 | Thyroid | PTC | cell junction assembly | 180/5968 | 420/18723 | 1.17e-06 | 1.69e-05 | 180 |
GO:003152917 | Thyroid | PTC | ruffle organization | 35/5968 | 56/18723 | 2.34e-06 | 3.11e-05 | 35 |
GO:0006898110 | Thyroid | PTC | receptor-mediated endocytosis | 112/5968 | 244/18723 | 2.87e-06 | 3.74e-05 | 112 |
GO:0001667112 | Thyroid | PTC | ameboidal-type cell migration | 198/5968 | 475/18723 | 3.36e-06 | 4.34e-05 | 198 |
GO:00609988 | Thyroid | PTC | regulation of dendritic spine development | 37/5968 | 61/18723 | 3.41e-06 | 4.40e-05 | 37 |
GO:0010634111 | Thyroid | PTC | positive regulation of epithelial cell migration | 85/5968 | 176/18723 | 3.83e-06 | 4.80e-05 | 85 |
GO:015011717 | Thyroid | PTC | positive regulation of cell-substrate junction organization | 23/5968 | 33/18723 | 9.16e-06 | 1.04e-04 | 23 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:190547725 | Thyroid | PTC | positive regulation of protein localization to membrane | 55/5968 | 106/18723 | 1.45e-05 | 1.55e-04 | 55 |
GO:009717815 | Thyroid | PTC | ruffle assembly | 28/5968 | 44/18723 | 1.46e-05 | 1.56e-04 | 28 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARF6 | SNV | Missense_Mutation | novel | c.390N>C | p.Met130Ile | p.M130I | P62330 | protein_coding | deleterious_low_confidence(0.03) | benign(0.029) | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ARF6 | SNV | Missense_Mutation | | c.433N>T | p.Arg145Trp | p.R145W | P62330 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.848) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | | c.91N>C | p.Tyr31His | p.Y31H | P62330 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ARF6 | SNV | Missense_Mutation | | c.433C>T | p.Arg145Trp | p.R145W | P62330 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.848) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | | c.415N>A | p.Leu139Met | p.L139M | P62330 | protein_coding | deleterious_low_confidence(0.04) | benign(0.41) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | | c.418N>T | p.Gly140Cys | p.G140C | P62330 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.884) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | | c.448N>C | p.Tyr150His | p.Y150H | P62330 | protein_coding | tolerated_low_confidence(0.15) | possibly_damaging(0.503) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | novel | c.246N>C | p.Gln82His | p.Q82H | P62330 | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.968) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | novel | c.446G>T | p.Trp149Leu | p.W149L | P62330 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARF6 | SNV | Missense_Mutation | novel | c.102N>T | p.Lys34Asn | p.K34N | P62330 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.989) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |