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Gene: VTA1 |
Gene summary for VTA1 |
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Gene information | Species | Human | Gene symbol | VTA1 | Gene ID | 51534 |
Gene name | vesicle trafficking 1 | |
Gene Alias | 6orf55 | |
Cytomap | 6q24.1-q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A087WY55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51534 | VTA1 | LZE4T | Human | Esophagus | ESCC | 9.76e-22 | 4.23e-01 | 0.0811 |
51534 | VTA1 | LZE5T | Human | Esophagus | ESCC | 2.01e-03 | 3.59e-01 | 0.0514 |
51534 | VTA1 | LZE7T | Human | Esophagus | ESCC | 1.70e-06 | 4.33e-01 | 0.0667 |
51534 | VTA1 | LZE8T | Human | Esophagus | ESCC | 9.89e-07 | 1.24e-01 | 0.067 |
51534 | VTA1 | LZE20T | Human | Esophagus | ESCC | 1.15e-05 | 1.91e-01 | 0.0662 |
51534 | VTA1 | LZE22T | Human | Esophagus | ESCC | 6.24e-03 | 1.49e-01 | 0.068 |
51534 | VTA1 | LZE24T | Human | Esophagus | ESCC | 2.58e-15 | 4.25e-01 | 0.0596 |
51534 | VTA1 | LZE6T | Human | Esophagus | ESCC | 3.42e-04 | 3.73e-01 | 0.0845 |
51534 | VTA1 | P2T-E | Human | Esophagus | ESCC | 5.50e-31 | 5.30e-01 | 0.1177 |
51534 | VTA1 | P4T-E | Human | Esophagus | ESCC | 3.84e-26 | 6.55e-01 | 0.1323 |
51534 | VTA1 | P5T-E | Human | Esophagus | ESCC | 1.18e-27 | 6.59e-01 | 0.1327 |
51534 | VTA1 | P8T-E | Human | Esophagus | ESCC | 1.09e-30 | 5.38e-01 | 0.0889 |
51534 | VTA1 | P9T-E | Human | Esophagus | ESCC | 3.87e-11 | 2.65e-01 | 0.1131 |
51534 | VTA1 | P10T-E | Human | Esophagus | ESCC | 4.41e-33 | 5.25e-01 | 0.116 |
51534 | VTA1 | P11T-E | Human | Esophagus | ESCC | 1.20e-17 | 7.06e-01 | 0.1426 |
51534 | VTA1 | P12T-E | Human | Esophagus | ESCC | 4.61e-28 | 4.62e-01 | 0.1122 |
51534 | VTA1 | P15T-E | Human | Esophagus | ESCC | 7.59e-40 | 7.63e-01 | 0.1149 |
51534 | VTA1 | P16T-E | Human | Esophagus | ESCC | 2.01e-44 | 7.63e-01 | 0.1153 |
51534 | VTA1 | P17T-E | Human | Esophagus | ESCC | 6.10e-13 | 4.66e-01 | 0.1278 |
51534 | VTA1 | P19T-E | Human | Esophagus | ESCC | 2.58e-11 | 1.09e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003298422 | Thyroid | ATC | protein-containing complex disassembly | 121/6293 | 224/18723 | 2.25e-10 | 6.59e-09 | 121 |
GO:000703423 | Thyroid | ATC | vacuolar transport | 89/6293 | 157/18723 | 2.26e-09 | 5.40e-08 | 89 |
GO:003250921 | Thyroid | ATC | endosome transport via multivesicular body sorting pathway | 25/6293 | 31/18723 | 1.01e-07 | 1.70e-06 | 25 |
GO:003625715 | Thyroid | ATC | multivesicular body organization | 25/6293 | 31/18723 | 1.01e-07 | 1.70e-06 | 25 |
GO:003625815 | Thyroid | ATC | multivesicular body assembly | 24/6293 | 30/18723 | 2.44e-07 | 3.77e-06 | 24 |
GO:000703216 | Thyroid | ATC | endosome organization | 48/6293 | 82/18723 | 3.13e-06 | 3.56e-05 | 48 |
GO:007198515 | Thyroid | ATC | multivesicular body sorting pathway | 26/6293 | 37/18723 | 5.64e-06 | 6.00e-05 | 26 |
GO:004532421 | Thyroid | ATC | late endosome to vacuole transport | 18/6293 | 25/18723 | 9.87e-05 | 7.19e-04 | 18 |
GO:001906821 | Thyroid | ATC | virion assembly | 23/6293 | 35/18723 | 1.03e-04 | 7.41e-04 | 23 |
GO:003251112 | Thyroid | ATC | late endosome to vacuole transport via multivesicular body sorting pathway | 13/6293 | 17/18723 | 3.73e-04 | 2.28e-03 | 13 |
GO:190489613 | Thyroid | ATC | ESCRT complex disassembly | 9/6293 | 10/18723 | 3.81e-04 | 2.31e-03 | 9 |
GO:190490313 | Thyroid | ATC | ESCRT III complex disassembly | 9/6293 | 10/18723 | 3.81e-04 | 2.31e-03 | 9 |
GO:004675515 | Thyroid | ATC | viral budding | 17/6293 | 26/18723 | 9.13e-04 | 4.92e-03 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VTA1 | SNV | Missense_Mutation | novel | c.241N>G | p.Thr81Ala | p.T81A | Q9NP79 | protein_coding | deleterious(0.03) | benign(0.378) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
VTA1 | SNV | Missense_Mutation | novel | c.642T>G | p.Ile214Met | p.I214M | Q9NP79 | protein_coding | deleterious(0.03) | possibly_damaging(0.776) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
VTA1 | SNV | Missense_Mutation | novel | c.372N>C | p.Leu124Phe | p.L124F | Q9NP79 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
VTA1 | SNV | Missense_Mutation | c.814N>T | p.Ala272Ser | p.A272S | Q9NP79 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VTA1 | SNV | Missense_Mutation | c.235N>A | p.Ala79Thr | p.A79T | Q9NP79 | protein_coding | deleterious(0) | possibly_damaging(0.491) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
VTA1 | SNV | Missense_Mutation | c.655N>T | p.His219Tyr | p.H219Y | Q9NP79 | protein_coding | tolerated(0.24) | probably_damaging(0.924) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VTA1 | SNV | Missense_Mutation | novel | c.518N>G | p.Asn173Ser | p.N173S | Q9NP79 | protein_coding | tolerated(0.47) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
VTA1 | SNV | Missense_Mutation | rs776504793 | c.647N>T | p.Pro216Leu | p.P216L | Q9NP79 | protein_coding | deleterious(0) | possibly_damaging(0.633) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
VTA1 | SNV | Missense_Mutation | c.692N>A | p.Ser231Asn | p.S231N | Q9NP79 | protein_coding | tolerated(0.52) | benign(0.009) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
VTA1 | SNV | Missense_Mutation | c.636A>G | p.Ile212Met | p.I212M | Q9NP79 | protein_coding | tolerated(0.1) | possibly_damaging(0.844) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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