![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: USP16 |
Gene summary for USP16 |
![]() |
Gene information | Species | Human | Gene symbol | USP16 | Gene ID | 10600 |
Gene name | ubiquitin specific peptidase 16 | |
Gene Alias | UBP-M | |
Cytomap | 21q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9Y5T5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10600 | USP16 | LZE4T | Human | Esophagus | ESCC | 1.91e-11 | 4.21e-01 | 0.0811 |
10600 | USP16 | LZE7T | Human | Esophagus | ESCC | 1.43e-10 | 8.32e-01 | 0.0667 |
10600 | USP16 | LZE8T | Human | Esophagus | ESCC | 1.24e-10 | 3.72e-01 | 0.067 |
10600 | USP16 | LZE24T | Human | Esophagus | ESCC | 6.50e-07 | 6.03e-02 | 0.0596 |
10600 | USP16 | LZE21T | Human | Esophagus | ESCC | 1.92e-06 | 2.50e-01 | 0.0655 |
10600 | USP16 | LZE6T | Human | Esophagus | ESCC | 4.13e-04 | 2.32e-01 | 0.0845 |
10600 | USP16 | P1T-E | Human | Esophagus | ESCC | 4.17e-10 | 6.72e-01 | 0.0875 |
10600 | USP16 | P2T-E | Human | Esophagus | ESCC | 4.23e-44 | 7.34e-01 | 0.1177 |
10600 | USP16 | P4T-E | Human | Esophagus | ESCC | 4.85e-40 | 9.19e-01 | 0.1323 |
10600 | USP16 | P5T-E | Human | Esophagus | ESCC | 2.04e-36 | 7.66e-01 | 0.1327 |
10600 | USP16 | P8T-E | Human | Esophagus | ESCC | 2.05e-26 | 5.20e-01 | 0.0889 |
10600 | USP16 | P9T-E | Human | Esophagus | ESCC | 1.95e-18 | 4.53e-01 | 0.1131 |
10600 | USP16 | P10T-E | Human | Esophagus | ESCC | 2.83e-43 | 8.32e-01 | 0.116 |
10600 | USP16 | P11T-E | Human | Esophagus | ESCC | 2.91e-20 | 7.60e-01 | 0.1426 |
10600 | USP16 | P12T-E | Human | Esophagus | ESCC | 1.95e-48 | 1.02e+00 | 0.1122 |
10600 | USP16 | P15T-E | Human | Esophagus | ESCC | 3.96e-18 | 4.75e-01 | 0.1149 |
10600 | USP16 | P16T-E | Human | Esophagus | ESCC | 9.74e-44 | 8.27e-01 | 0.1153 |
10600 | USP16 | P17T-E | Human | Esophagus | ESCC | 1.36e-10 | 4.06e-01 | 0.1278 |
10600 | USP16 | P19T-E | Human | Esophagus | ESCC | 1.54e-06 | 5.66e-01 | 0.1662 |
10600 | USP16 | P20T-E | Human | Esophagus | ESCC | 1.94e-13 | 3.39e-01 | 0.1124 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00002803 | Skin | cSCC | nuclear division | 178/4864 | 439/18723 | 1.17e-11 | 5.93e-10 | 178 |
GO:001657024 | Skin | cSCC | histone modification | 179/4864 | 463/18723 | 9.65e-10 | 3.74e-08 | 179 |
GO:000641423 | Skin | cSCC | translational elongation | 30/4864 | 55/18723 | 6.13e-06 | 8.70e-05 | 30 |
GO:003552012 | Skin | cSCC | monoubiquitinated protein deubiquitination | 8/4864 | 10/18723 | 5.51e-04 | 4.04e-03 | 8 |
GO:00512624 | Skin | cSCC | protein tetramerization | 35/4864 | 87/18723 | 2.52e-03 | 1.43e-02 | 35 |
GO:00706464 | Skin | cSCC | protein modification by small protein removal | 55/4864 | 157/18723 | 7.29e-03 | 3.46e-02 | 55 |
GO:001657010 | Thyroid | PTC | histone modification | 235/5968 | 463/18723 | 1.17e-17 | 1.15e-15 | 235 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0034250113 | Thyroid | PTC | positive regulation of cellular amide metabolic process | 98/5968 | 162/18723 | 5.26e-14 | 3.04e-12 | 98 |
GO:0045727113 | Thyroid | PTC | positive regulation of translation | 84/5968 | 136/18723 | 6.52e-13 | 3.08e-11 | 84 |
GO:01400148 | Thyroid | PTC | mitotic nuclear division | 135/5968 | 287/18723 | 4.90e-08 | 1.04e-06 | 135 |
GO:00706465 | Thyroid | PTC | protein modification by small protein removal | 71/5968 | 157/18723 | 3.03e-04 | 2.12e-03 | 71 |
GO:00482855 | Thyroid | PTC | organelle fission | 188/5968 | 488/18723 | 9.64e-04 | 5.77e-03 | 188 |
GO:00705363 | Thyroid | PTC | protein K63-linked deubiquitination | 20/5968 | 35/18723 | 1.75e-03 | 9.51e-03 | 20 |
GO:00355205 | Thyroid | PTC | monoubiquitinated protein deubiquitination | 8/5968 | 10/18723 | 2.46e-03 | 1.27e-02 | 8 |
GO:00002804 | Thyroid | PTC | nuclear division | 167/5968 | 439/18723 | 3.27e-03 | 1.60e-02 | 167 |
GO:00165794 | Thyroid | PTC | protein deubiquitination | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:000641735 | Thyroid | ATC | regulation of translation | 236/6293 | 468/18723 | 2.39e-14 | 1.34e-12 | 236 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP16 | SNV | Missense_Mutation | novel | c.1066G>C | p.Asp356His | p.D356H | Q9Y5T5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
USP16 | SNV | Missense_Mutation | novel | c.194C>T | p.Thr65Ile | p.T65I | Q9Y5T5 | protein_coding | tolerated(0.09) | benign(0.073) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
USP16 | SNV | Missense_Mutation | c.911T>C | p.Leu304Pro | p.L304P | Q9Y5T5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
USP16 | deletion | Frame_Shift_Del | c.814delN | p.Lys273ArgfsTer4 | p.K273Rfs*4 | Q9Y5T5 | protein_coding | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
USP16 | insertion | Frame_Shift_Ins | rs781590124 | c.1041_1042insA | p.Ser350IlefsTer7 | p.S350Ifs*7 | Q9Y5T5 | protein_coding | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
USP16 | SNV | Missense_Mutation | rs776153683 | c.2123N>A | p.Arg708His | p.R708H | Q9Y5T5 | protein_coding | tolerated(0.13) | benign(0.035) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
USP16 | deletion | Frame_Shift_Del | novel | c.2155delA | p.Ile719SerfsTer2 | p.I719Sfs*2 | Q9Y5T5 | protein_coding | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
USP16 | SNV | Missense_Mutation | c.1481A>G | p.Lys494Arg | p.K494R | Q9Y5T5 | protein_coding | tolerated(0.16) | benign(0.037) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP16 | SNV | Missense_Mutation | rs768071962 | c.2122C>T | p.Arg708Cys | p.R708C | Q9Y5T5 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP16 | SNV | Missense_Mutation | novel | c.1517N>C | p.Lys506Thr | p.K506T | Q9Y5T5 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |