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Gene: ULK1 |
Gene summary for ULK1 |
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Gene information | Species | Human | Gene symbol | ULK1 | Gene ID | 8408 |
Gene name | unc-51 like autophagy activating kinase 1 | |
Gene Alias | ATG1 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | O75385 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8408 | ULK1 | HCC1_Meng | Human | Liver | HCC | 1.92e-22 | 5.09e-03 | 0.0246 |
8408 | ULK1 | HCC2_Meng | Human | Liver | HCC | 3.18e-08 | 4.85e-02 | 0.0107 |
8408 | ULK1 | HCC1 | Human | Liver | HCC | 2.70e-02 | 3.02e+00 | 0.5336 |
8408 | ULK1 | HCC2 | Human | Liver | HCC | 6.07e-10 | 2.67e+00 | 0.5341 |
8408 | ULK1 | S014 | Human | Liver | HCC | 1.58e-04 | 4.24e-01 | 0.2254 |
8408 | ULK1 | S015 | Human | Liver | HCC | 2.96e-05 | 4.89e-01 | 0.2375 |
8408 | ULK1 | S016 | Human | Liver | HCC | 1.62e-03 | 3.27e-01 | 0.2243 |
8408 | ULK1 | S027 | Human | Liver | HCC | 1.68e-07 | 8.42e-01 | 0.2446 |
8408 | ULK1 | S028 | Human | Liver | HCC | 1.30e-11 | 6.24e-01 | 0.2503 |
8408 | ULK1 | S029 | Human | Liver | HCC | 1.11e-06 | 5.11e-01 | 0.2581 |
8408 | ULK1 | C30 | Human | Oral cavity | OSCC | 2.30e-11 | 6.00e-01 | 0.3055 |
8408 | ULK1 | C38 | Human | Oral cavity | OSCC | 1.51e-06 | 9.25e-01 | 0.172 |
8408 | ULK1 | C43 | Human | Oral cavity | OSCC | 2.39e-15 | 2.66e-01 | 0.1704 |
8408 | ULK1 | C51 | Human | Oral cavity | OSCC | 5.20e-09 | 5.87e-01 | 0.2674 |
8408 | ULK1 | C57 | Human | Oral cavity | OSCC | 2.88e-02 | 2.63e-01 | 0.1679 |
8408 | ULK1 | C08 | Human | Oral cavity | OSCC | 3.18e-05 | 1.53e-01 | 0.1919 |
8408 | ULK1 | LN22 | Human | Oral cavity | OSCC | 2.98e-03 | 6.13e-01 | 0.1733 |
8408 | ULK1 | EOLP-1 | Human | Oral cavity | EOLP | 4.01e-04 | 1.27e-01 | -0.0202 |
8408 | ULK1 | SYSMH1 | Human | Oral cavity | OSCC | 6.71e-15 | 2.94e-01 | 0.1127 |
8408 | ULK1 | SYSMH2 | Human | Oral cavity | OSCC | 1.85e-06 | 1.58e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001097515 | Oral cavity | EOLP | regulation of neuron projection development | 86/2218 | 445/18723 | 2.75e-06 | 6.05e-05 | 86 |
GO:190211712 | Oral cavity | EOLP | positive regulation of organelle assembly | 22/2218 | 67/18723 | 4.97e-06 | 1.02e-04 | 22 |
GO:001050821 | Oral cavity | EOLP | positive regulation of autophagy | 33/2218 | 124/18723 | 5.07e-06 | 1.03e-04 | 33 |
GO:190211521 | Oral cavity | EOLP | regulation of organelle assembly | 43/2218 | 186/18723 | 1.11e-05 | 1.94e-04 | 43 |
GO:000155823 | Oral cavity | EOLP | regulation of cell growth | 78/2218 | 414/18723 | 2.02e-05 | 3.19e-04 | 78 |
GO:004677713 | Oral cavity | EOLP | protein autophosphorylation | 49/2218 | 227/18723 | 2.04e-05 | 3.21e-04 | 49 |
GO:001623911 | Oral cavity | EOLP | positive regulation of macroautophagy | 20/2218 | 63/18723 | 2.32e-05 | 3.50e-04 | 20 |
GO:007149625 | Oral cavity | EOLP | cellular response to external stimulus | 63/2218 | 320/18723 | 3.18e-05 | 4.49e-04 | 63 |
GO:003166823 | Oral cavity | EOLP | cellular response to extracellular stimulus | 51/2218 | 246/18723 | 4.36e-05 | 5.88e-04 | 51 |
GO:00486389 | Oral cavity | EOLP | regulation of developmental growth | 64/2218 | 330/18723 | 4.45e-05 | 5.96e-04 | 64 |
GO:004858815 | Oral cavity | EOLP | developmental cell growth | 49/2218 | 234/18723 | 4.67e-05 | 6.20e-04 | 49 |
GO:004440325 | Oral cavity | EOLP | biological process involved in symbiotic interaction | 57/2218 | 290/18723 | 7.75e-05 | 9.39e-04 | 57 |
GO:004259422 | Oral cavity | EOLP | response to starvation | 42/2218 | 197/18723 | 1.03e-04 | 1.17e-03 | 42 |
GO:003166923 | Oral cavity | EOLP | cellular response to nutrient levels | 44/2218 | 215/18723 | 1.92e-04 | 1.96e-03 | 44 |
GO:004592613 | Oral cavity | EOLP | negative regulation of growth | 49/2218 | 249/18723 | 2.31e-04 | 2.26e-03 | 49 |
GO:003166725 | Oral cavity | EOLP | response to nutrient levels | 82/2218 | 474/18723 | 2.59e-04 | 2.52e-03 | 82 |
GO:00440901 | Oral cavity | EOLP | positive regulation of vacuole organization | 7/2218 | 13/18723 | 2.90e-04 | 2.74e-03 | 7 |
GO:000703321 | Oral cavity | EOLP | vacuole organization | 37/2218 | 180/18723 | 5.45e-04 | 4.67e-03 | 37 |
GO:004867515 | Oral cavity | EOLP | axon extension | 27/2218 | 120/18723 | 7.04e-04 | 5.78e-03 | 27 |
GO:190300822 | Oral cavity | EOLP | organelle disassembly | 26/2218 | 114/18723 | 7.06e-04 | 5.78e-03 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0501721 | Liver | HCC | Spinocerebellar ataxia | 92/4020 | 143/8465 | 3.20e-05 | 1.88e-04 | 1.04e-04 | 92 |
hsa0421121 | Liver | HCC | Longevity regulating pathway | 61/4020 | 89/8465 | 4.46e-05 | 2.37e-04 | 1.32e-04 | 61 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0501632 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0501731 | Liver | HCC | Spinocerebellar ataxia | 92/4020 | 143/8465 | 3.20e-05 | 1.88e-04 | 1.04e-04 | 92 |
hsa0421131 | Liver | HCC | Longevity regulating pathway | 61/4020 | 89/8465 | 4.46e-05 | 2.37e-04 | 1.32e-04 | 61 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ULK1 | SNV | Missense_Mutation | novel | c.989N>T | p.Ser330Phe | p.S330F | O75385 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ULK1 | SNV | Missense_Mutation | c.644T>C | p.Leu215Pro | p.L215P | O75385 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ULK1 | insertion | In_Frame_Ins | novel | c.247-1_247insTTTAAGTTTTGTATTTTTAGTAGA | p.Gln82_Glu83insPheLysPheCysIlePheSerArg | p.Q82_E83insFKFCIFSR | O75385 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ULK1 | deletion | Frame_Shift_Del | novel | c.1470delN | p.Ala491ProfsTer156 | p.A491Pfs*156 | O75385 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ULK1 | SNV | Missense_Mutation | novel | c.2048N>G | p.Glu683Gly | p.E683G | O75385 | protein_coding | tolerated(0.13) | benign(0.054) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ULK1 | SNV | Missense_Mutation | novel | c.448N>A | p.Ala150Thr | p.A150T | O75385 | protein_coding | tolerated(0.27) | benign(0.017) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ULK1 | SNV | Missense_Mutation | rs757530790 | c.2009N>C | p.Phe670Ser | p.F670S | O75385 | protein_coding | tolerated(0.17) | benign(0.074) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ULK1 | SNV | Missense_Mutation | c.1379N>G | p.Ser460Cys | p.S460C | O75385 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ULK1 | SNV | Missense_Mutation | rs761511646 | c.848N>T | p.Ser283Leu | p.S283L | O75385 | protein_coding | deleterious(0.02) | benign(0.132) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
ULK1 | SNV | Missense_Mutation | rs150697369 | c.1631C>G | p.Ser544Cys | p.S544C | O75385 | protein_coding | tolerated(0.08) | possibly_damaging(0.635) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8408 | ULK1 | KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565893 |
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