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Gene: UCP2 |
Gene summary for UCP2 |
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Gene information | Species | Human | Gene symbol | UCP2 | Gene ID | 7351 |
Gene name | uncoupling protein 2 | |
Gene Alias | BMIQ4 | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R5N5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7351 | UCP2 | GSM4909288 | Human | Breast | IDC | 4.04e-05 | 1.70e-01 | 0.0988 |
7351 | UCP2 | GSM4909290 | Human | Breast | IDC | 8.76e-11 | 4.50e-01 | 0.2096 |
7351 | UCP2 | GSM4909291 | Human | Breast | IDC | 2.73e-13 | 5.52e-01 | 0.1753 |
7351 | UCP2 | GSM4909297 | Human | Breast | IDC | 4.70e-02 | -8.43e-02 | 0.1517 |
7351 | UCP2 | GSM4909308 | Human | Breast | IDC | 2.54e-07 | 3.41e-01 | 0.158 |
7351 | UCP2 | GSM4909311 | Human | Breast | IDC | 2.31e-04 | -6.56e-02 | 0.1534 |
7351 | UCP2 | GSM4909312 | Human | Breast | IDC | 2.71e-04 | 2.66e-01 | 0.1552 |
7351 | UCP2 | GSM4909313 | Human | Breast | IDC | 1.70e-08 | 4.08e-01 | 0.0391 |
7351 | UCP2 | GSM4909316 | Human | Breast | IDC | 1.66e-07 | 5.51e-01 | 0.21 |
7351 | UCP2 | GSM4909319 | Human | Breast | IDC | 5.94e-07 | -9.74e-02 | 0.1563 |
7351 | UCP2 | GSM4909321 | Human | Breast | IDC | 2.98e-03 | 1.65e-01 | 0.1559 |
7351 | UCP2 | brca2 | Human | Breast | Precancer | 3.69e-10 | 4.51e-01 | -0.024 |
7351 | UCP2 | M2 | Human | Breast | IDC | 4.97e-06 | 4.94e-01 | 0.21 |
7351 | UCP2 | M5 | Human | Breast | IDC | 6.07e-07 | 6.86e-01 | 0.1598 |
7351 | UCP2 | NCCBC11 | Human | Breast | DCIS | 2.28e-02 | 4.39e-01 | 0.1232 |
7351 | UCP2 | NCCBC14 | Human | Breast | DCIS | 2.16e-06 | 3.36e-01 | 0.2021 |
7351 | UCP2 | NCCBC3 | Human | Breast | DCIS | 7.14e-04 | 3.23e-01 | 0.1198 |
7351 | UCP2 | NCCBC5 | Human | Breast | DCIS | 7.88e-09 | 4.19e-01 | 0.2046 |
7351 | UCP2 | P2 | Human | Breast | IDC | 8.72e-10 | 5.62e-01 | 0.21 |
7351 | UCP2 | DCIS2 | Human | Breast | DCIS | 4.17e-03 | -1.14e-01 | 0.0085 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000940922 | Breast | DCIS | response to cold | 11/1390 | 49/18723 | 7.63e-04 | 8.95e-03 | 11 |
GO:005070822 | Breast | DCIS | regulation of protein secretion | 35/1390 | 268/18723 | 7.83e-04 | 9.11e-03 | 35 |
GO:004259323 | Breast | DCIS | glucose homeostasis | 34/1390 | 258/18723 | 7.87e-04 | 9.11e-03 | 34 |
GO:009742122 | Breast | DCIS | liver regeneration | 9/1390 | 35/18723 | 8.05e-04 | 9.27e-03 | 9 |
GO:003350023 | Breast | DCIS | carbohydrate homeostasis | 34/1390 | 259/18723 | 8.43e-04 | 9.58e-03 | 34 |
GO:000167823 | Breast | DCIS | cellular glucose homeostasis | 24/1390 | 172/18723 | 2.05e-03 | 1.91e-02 | 24 |
GO:007133322 | Breast | DCIS | cellular response to glucose stimulus | 21/1390 | 151/18723 | 3.92e-03 | 3.12e-02 | 21 |
GO:003286813 | Breast | DCIS | response to insulin | 32/1390 | 264/18723 | 4.20e-03 | 3.31e-02 | 32 |
GO:003286913 | Breast | DCIS | cellular response to insulin stimulus | 26/1390 | 203/18723 | 4.53e-03 | 3.47e-02 | 26 |
GO:007133122 | Breast | DCIS | cellular response to hexose stimulus | 21/1390 | 153/18723 | 4.58e-03 | 3.50e-02 | 21 |
GO:007132222 | Breast | DCIS | cellular response to carbohydrate stimulus | 22/1390 | 163/18723 | 4.62e-03 | 3.52e-02 | 22 |
GO:007132622 | Breast | DCIS | cellular response to monosaccharide stimulus | 21/1390 | 154/18723 | 4.94e-03 | 3.71e-02 | 21 |
GO:003166922 | Breast | DCIS | cellular response to nutrient levels | 27/1390 | 215/18723 | 5.06e-03 | 3.74e-02 | 27 |
GO:000926713 | Breast | DCIS | cellular response to starvation | 21/1390 | 156/18723 | 5.74e-03 | 4.13e-02 | 21 |
GO:00423911 | Breast | DCIS | regulation of membrane potential | 47/1390 | 434/18723 | 5.87e-03 | 4.20e-02 | 47 |
GO:007169222 | Breast | DCIS | protein localization to extracellular region | 41/1390 | 368/18723 | 6.01e-03 | 4.29e-02 | 41 |
GO:000930622 | Breast | DCIS | protein secretion | 40/1390 | 359/18723 | 6.59e-03 | 4.61e-02 | 40 |
GO:003559222 | Breast | DCIS | establishment of protein localization to extracellular region | 40/1390 | 360/18723 | 6.90e-03 | 4.77e-02 | 40 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UCP2 | SNV | Missense_Mutation | novel | c.22N>A | p.Asp8Asn | p.D8N | P55851 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A2-A3XZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
UCP2 | SNV | Missense_Mutation | c.452G>C | p.Gly151Ala | p.G151A | P55851 | protein_coding | tolerated(0.57) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UCP2 | SNV | Missense_Mutation | c.94N>A | p.Phe32Ile | p.F32I | P55851 | protein_coding | tolerated(0.51) | possibly_damaging(0.643) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
UCP2 | SNV | Missense_Mutation | c.52N>A | p.Leu18Ile | p.L18I | P55851 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR | |
UCP2 | SNV | Missense_Mutation | c.488N>T | p.Tyr163Phe | p.Y163F | P55851 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
UCP2 | deletion | Frame_Shift_Del | rs770840871 | c.143_144delAG | p.Gln48ArgfsTer25 | p.Q48Rfs*25 | P55851 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
UCP2 | SNV | Missense_Mutation | rs780835346 | c.292G>A | p.Gly98Ser | p.G98S | P55851 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UCP2 | SNV | Missense_Mutation | rs781271646 | c.154N>T | p.Arg52Cys | p.R52C | P55851 | protein_coding | deleterious(0.05) | benign(0.09) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
UCP2 | deletion | Frame_Shift_Del | c.32delN | p.Pro11LeufsTer5 | p.P11Lfs*5 | P55851 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
UCP2 | SNV | Missense_Mutation | rs145061662 | c.263G>A | p.Arg88His | p.R88H | P55851 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | INTRALIPID | SOYBEAN OIL | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | BRL49653 | 9299560 | ||
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | HEPARIN | HEPARIN | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | ANTIOXIDANT | 15642337 | ||
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | TRIIODOTHYRONINE | LIOTHYRONINE SODIUM | 9428737,10444435 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | SALINE | SODIUM CHLORIDE | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | CL-316,243 |
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