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Gene: UCHL1 |
Gene summary for UCHL1 |
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Gene information | Species | Human | Gene symbol | UCHL1 | Gene ID | 7345 |
Gene name | ubiquitin C-terminal hydrolase L1 | |
Gene Alias | HEL-117 | |
Cytomap | 4p13 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P09936 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7345 | UCHL1 | sample1 | Human | Cervix | CC | 5.15e-21 | 5.30e-01 | 0.0959 |
7345 | UCHL1 | T1 | Human | Cervix | CC | 5.31e-19 | 3.84e-01 | 0.0918 |
7345 | UCHL1 | LZE2T | Human | Esophagus | ESCC | 1.57e-11 | 1.86e+00 | 0.082 |
7345 | UCHL1 | LZE4T | Human | Esophagus | ESCC | 8.39e-40 | 1.68e+00 | 0.0811 |
7345 | UCHL1 | LZE7T | Human | Esophagus | ESCC | 4.18e-27 | 2.21e+00 | 0.0667 |
7345 | UCHL1 | LZE6T | Human | Esophagus | ESCC | 2.17e-12 | 2.06e+00 | 0.0845 |
7345 | UCHL1 | P2T-E | Human | Esophagus | ESCC | 1.30e-75 | 2.11e+00 | 0.1177 |
7345 | UCHL1 | P5T-E | Human | Esophagus | ESCC | 8.28e-08 | 2.84e-01 | 0.1327 |
7345 | UCHL1 | P10T-E | Human | Esophagus | ESCC | 5.18e-87 | 1.78e+00 | 0.116 |
7345 | UCHL1 | P11T-E | Human | Esophagus | ESCC | 3.72e-24 | 1.98e+00 | 0.1426 |
7345 | UCHL1 | P12T-E | Human | Esophagus | ESCC | 2.09e-64 | 1.93e+00 | 0.1122 |
7345 | UCHL1 | P15T-E | Human | Esophagus | ESCC | 1.68e-44 | 1.97e+00 | 0.1149 |
7345 | UCHL1 | P16T-E | Human | Esophagus | ESCC | 4.89e-19 | 6.74e-01 | 0.1153 |
7345 | UCHL1 | P19T-E | Human | Esophagus | ESCC | 1.78e-05 | 1.08e+00 | 0.1662 |
7345 | UCHL1 | P21T-E | Human | Esophagus | ESCC | 1.67e-76 | 2.86e+00 | 0.1617 |
7345 | UCHL1 | P22T-E | Human | Esophagus | ESCC | 1.53e-05 | 1.59e-01 | 0.1236 |
7345 | UCHL1 | P24T-E | Human | Esophagus | ESCC | 8.36e-11 | 5.43e-01 | 0.1287 |
7345 | UCHL1 | P26T-E | Human | Esophagus | ESCC | 5.87e-08 | 1.42e-01 | 0.1276 |
7345 | UCHL1 | P27T-E | Human | Esophagus | ESCC | 2.69e-46 | 1.50e+00 | 0.1055 |
7345 | UCHL1 | P28T-E | Human | Esophagus | ESCC | 3.17e-14 | 4.18e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051348110 | Oral cavity | LP | negative regulation of transferase activity | 106/4623 | 268/18723 | 4.60e-08 | 1.61e-06 | 106 |
GO:001624113 | Oral cavity | LP | regulation of macroautophagy | 61/4623 | 141/18723 | 1.00e-06 | 2.50e-05 | 61 |
GO:0010563110 | Oral cavity | LP | negative regulation of phosphorus metabolic process | 153/4623 | 442/18723 | 1.47e-06 | 3.53e-05 | 153 |
GO:0045936110 | Oral cavity | LP | negative regulation of phosphate metabolic process | 152/4623 | 441/18723 | 2.10e-06 | 4.77e-05 | 152 |
GO:0042326110 | Oral cavity | LP | negative regulation of phosphorylation | 131/4623 | 385/18723 | 2.10e-05 | 3.46e-04 | 131 |
GO:003367318 | Oral cavity | LP | negative regulation of kinase activity | 86/4623 | 237/18723 | 4.19e-05 | 6.07e-04 | 86 |
GO:0001933110 | Oral cavity | LP | negative regulation of protein phosphorylation | 117/4623 | 342/18723 | 4.34e-05 | 6.22e-04 | 117 |
GO:000646919 | Oral cavity | LP | negative regulation of protein kinase activity | 78/4623 | 212/18723 | 5.45e-05 | 7.55e-04 | 78 |
GO:004340918 | Oral cavity | LP | negative regulation of MAPK cascade | 67/4623 | 180/18723 | 1.18e-04 | 1.40e-03 | 67 |
GO:007190015 | Oral cavity | LP | regulation of protein serine/threonine kinase activity | 119/4623 | 359/18723 | 1.70e-04 | 1.90e-03 | 119 |
GO:00434071 | Oral cavity | LP | negative regulation of MAP kinase activity | 27/4623 | 59/18723 | 3.38e-04 | 3.37e-03 | 27 |
GO:007238412 | Oral cavity | LP | organelle transport along microtubule | 35/4623 | 85/18723 | 5.94e-04 | 5.44e-03 | 35 |
GO:003070516 | Oral cavity | LP | cytoskeleton-dependent intracellular transport | 68/4623 | 195/18723 | 8.92e-04 | 7.64e-03 | 68 |
GO:001097012 | Oral cavity | LP | transport along microtubule | 56/4623 | 155/18723 | 9.49e-04 | 8.04e-03 | 56 |
GO:004340512 | Oral cavity | LP | regulation of MAP kinase activity | 62/4623 | 177/18723 | 1.29e-03 | 1.04e-02 | 62 |
GO:000941019 | Oral cavity | LP | response to xenobiotic stimulus | 141/4623 | 462/18723 | 2.33e-03 | 1.68e-02 | 141 |
GO:000808815 | Oral cavity | LP | axo-dendritic transport | 30/4623 | 75/18723 | 2.42e-03 | 1.73e-02 | 30 |
GO:007190111 | Oral cavity | LP | negative regulation of protein serine/threonine kinase activity | 42/4623 | 120/18723 | 7.27e-03 | 4.06e-02 | 42 |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05012310 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501222 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501232 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05012113 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05012210 | Oral cavity | LP | Parkinson disease | 166/2418 | 266/8465 | 2.02e-31 | 3.36e-29 | 2.17e-29 | 166 |
hsa0502229 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0501238 | Oral cavity | LP | Parkinson disease | 166/2418 | 266/8465 | 2.02e-31 | 3.36e-29 | 2.17e-29 | 166 |
hsa0502237 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UCHL1 | SNV | Missense_Mutation | novel | c.31G>C | p.Glu11Gln | p.E11Q | P09936 | protein_coding | tolerated(0.07) | benign(0.037) | TCGA-Q1-A73R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | rs139583787 | c.457C>T | p.Arg153Trp | p.R153W | P09936 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
UCHL1 | SNV | Missense_Mutation | rs770039881 | c.649N>A | p.Val217Met | p.V217M | P09936 | protein_coding | tolerated(0.13) | possibly_damaging(0.696) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.466G>T | p.Asp156Tyr | p.D156Y | P09936 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.420G>T | p.Gln140His | p.Q140H | P09936 | protein_coding | tolerated(0.54) | possibly_damaging(0.745) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | c.458G>A | p.Arg153Gln | p.R153Q | P09936 | protein_coding | tolerated(0.16) | possibly_damaging(0.753) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UCHL1 | SNV | Missense_Mutation | rs139583787 | c.457N>T | p.Arg153Trp | p.R153W | P09936 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | rs139583787 | c.457N>T | p.Arg153Trp | p.R153W | P09936 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.522N>C | p.Glu174Asp | p.E174D | P09936 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.23T>C | p.Ile8Thr | p.I8T | P09936 | protein_coding | tolerated(0.28) | probably_damaging(0.992) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7345 | UCHL1 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166861 |
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