Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TP53INP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TP53INP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/TP53INP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TP53INP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048102 | Prostate | BPH | autophagic cell death | 7/3107 | 11/18723 | 6.10e-04 | 4.16e-03 | 7 |
GO:009875416 | Prostate | BPH | detoxification | 41/3107 | 152/18723 | 8.07e-04 | 5.27e-03 | 41 |
GO:00070334 | Prostate | BPH | vacuole organization | 45/3107 | 180/18723 | 2.49e-03 | 1.34e-02 | 45 |
GO:00346443 | Prostate | BPH | cellular response to UV | 25/3107 | 90/18723 | 5.18e-03 | 2.43e-02 | 25 |
GO:00094113 | Prostate | BPH | response to UV | 37/3107 | 149/18723 | 6.40e-03 | 2.91e-02 | 37 |
GO:00973062 | Prostate | BPH | cellular response to alcohol | 25/3107 | 93/18723 | 8.12e-03 | 3.53e-02 | 25 |
GO:00481456 | Prostate | BPH | regulation of fibroblast proliferation | 22/3107 | 80/18723 | 9.50e-03 | 4.03e-02 | 22 |
GO:00000453 | Prostate | BPH | autophagosome assembly | 26/3107 | 99/18723 | 9.68e-03 | 4.09e-02 | 26 |
GO:00481445 | Prostate | BPH | fibroblast proliferation | 22/3107 | 81/18723 | 1.10e-02 | 4.53e-02 | 22 |
GO:000989619 | Prostate | Tumor | positive regulation of catabolic process | 155/3246 | 492/18723 | 5.62e-15 | 8.52e-13 | 155 |
GO:000697919 | Prostate | Tumor | response to oxidative stress | 144/3246 | 446/18723 | 5.75e-15 | 8.52e-13 | 144 |
GO:003133119 | Prostate | Tumor | positive regulation of cellular catabolic process | 134/3246 | 427/18723 | 5.54e-13 | 5.84e-11 | 134 |
GO:006219719 | Prostate | Tumor | cellular response to chemical stress | 112/3246 | 337/18723 | 7.53e-13 | 7.67e-11 | 112 |
GO:003459919 | Prostate | Tumor | cellular response to oxidative stress | 92/3246 | 288/18723 | 8.68e-10 | 4.22e-08 | 92 |
GO:001623614 | Prostate | Tumor | macroautophagy | 87/3246 | 291/18723 | 7.82e-08 | 2.16e-06 | 87 |
GO:000926615 | Prostate | Tumor | response to temperature stimulus | 59/3246 | 178/18723 | 2.14e-07 | 5.21e-06 | 59 |
GO:000940816 | Prostate | Tumor | response to heat | 41/3246 | 110/18723 | 4.75e-07 | 1.04e-05 | 41 |
GO:007121415 | Prostate | Tumor | cellular response to abiotic stimulus | 92/3246 | 331/18723 | 1.25e-06 | 2.32e-05 | 92 |
GO:010400415 | Prostate | Tumor | cellular response to environmental stimulus | 92/3246 | 331/18723 | 1.25e-06 | 2.32e-05 | 92 |
GO:001050614 | Prostate | Tumor | regulation of autophagy | 86/3246 | 317/18723 | 7.77e-06 | 1.16e-04 | 86 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TP53INP1 | SNV | Missense_Mutation | novel | c.379N>T | p.Pro127Ser | p.P127S | Q96A56 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TP53INP1 | SNV | Missense_Mutation | | c.649N>A | p.Asp217Asn | p.D217N | Q96A56 | protein_coding | tolerated(0.13) | possibly_damaging(0.536) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TP53INP1 | SNV | Missense_Mutation | novel | c.82N>T | p.Asp28Tyr | p.D28Y | Q96A56 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TP53INP1 | insertion | Frame_Shift_Ins | novel | c.511_512insATCAGTG | p.Cys171TyrfsTer32 | p.C171Yfs*32 | Q96A56 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
TP53INP1 | insertion | Frame_Shift_Ins | novel | c.509_510insACCAATTGATAACCAATCACATAGTT | p.His170GlnfsTer35 | p.H170Qfs*35 | Q96A56 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
TP53INP1 | insertion | In_Frame_Ins | novel | c.139_140insTCTTCTTTCTCTTCATTTATACCC | p.Glu47delinsValPhePheLeuPheIleTyrThrGln | p.E47delinsVFFLFIYTQ | Q96A56 | protein_coding | | | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TP53INP1 | SNV | Missense_Mutation | | c.136N>A | p.Glu46Lys | p.E46K | Q96A56 | protein_coding | tolerated(0.12) | benign(0.049) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TP53INP1 | SNV | Missense_Mutation | novel | c.421N>T | p.Leu141Phe | p.L141F | Q96A56 | protein_coding | deleterious(0.02) | possibly_damaging(0.787) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TP53INP1 | deletion | Frame_Shift_Del | novel | c.26_29delTTGT | p.Phe9TrpfsTer28 | p.F9Wfs*28 | Q96A56 | protein_coding | | | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TP53INP1 | SNV | Missense_Mutation | | c.649N>A | p.Asp217Asn | p.D217N | Q96A56 | protein_coding | tolerated(0.13) | possibly_damaging(0.536) | TCGA-AA-3837-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |