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Gene: TNFRSF14 |
Gene summary for TNFRSF14 |
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Gene information | Species | Human | Gene symbol | TNFRSF14 | Gene ID | 8764 |
Gene name | TNF receptor superfamily member 14 | |
Gene Alias | ATAR | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024R052 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8764 | TNFRSF14 | LZE4T | Human | Esophagus | ESCC | 1.30e-10 | 2.25e-01 | 0.0811 |
8764 | TNFRSF14 | LZE8T | Human | Esophagus | ESCC | 8.91e-12 | 3.24e-01 | 0.067 |
8764 | TNFRSF14 | LZE20T | Human | Esophagus | ESCC | 1.28e-05 | 3.26e-01 | 0.0662 |
8764 | TNFRSF14 | LZE22D1 | Human | Esophagus | HGIN | 4.94e-03 | 1.18e-01 | 0.0595 |
8764 | TNFRSF14 | LZE22T | Human | Esophagus | ESCC | 3.61e-03 | 1.32e-01 | 0.068 |
8764 | TNFRSF14 | LZE24T | Human | Esophagus | ESCC | 1.01e-12 | 4.09e-01 | 0.0596 |
8764 | TNFRSF14 | LZE6T | Human | Esophagus | ESCC | 2.02e-04 | 1.91e-01 | 0.0845 |
8764 | TNFRSF14 | P1T-E | Human | Esophagus | ESCC | 2.56e-04 | 4.21e-01 | 0.0875 |
8764 | TNFRSF14 | P2T-E | Human | Esophagus | ESCC | 4.53e-28 | 3.31e-01 | 0.1177 |
8764 | TNFRSF14 | P4T-E | Human | Esophagus | ESCC | 2.28e-11 | 2.84e-01 | 0.1323 |
8764 | TNFRSF14 | P5T-E | Human | Esophagus | ESCC | 1.36e-10 | 1.17e-01 | 0.1327 |
8764 | TNFRSF14 | P8T-E | Human | Esophagus | ESCC | 6.64e-45 | 9.33e-01 | 0.0889 |
8764 | TNFRSF14 | P9T-E | Human | Esophagus | ESCC | 6.55e-04 | 1.83e-01 | 0.1131 |
8764 | TNFRSF14 | P10T-E | Human | Esophagus | ESCC | 1.21e-07 | 2.22e-02 | 0.116 |
8764 | TNFRSF14 | P11T-E | Human | Esophagus | ESCC | 6.67e-10 | 4.77e-01 | 0.1426 |
8764 | TNFRSF14 | P12T-E | Human | Esophagus | ESCC | 2.88e-05 | 6.19e-02 | 0.1122 |
8764 | TNFRSF14 | P15T-E | Human | Esophagus | ESCC | 2.32e-07 | 2.56e-01 | 0.1149 |
8764 | TNFRSF14 | P16T-E | Human | Esophagus | ESCC | 1.81e-16 | 1.28e-01 | 0.1153 |
8764 | TNFRSF14 | P17T-E | Human | Esophagus | ESCC | 1.14e-08 | 4.40e-01 | 0.1278 |
8764 | TNFRSF14 | P20T-E | Human | Esophagus | ESCC | 9.66e-12 | 3.23e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00224085 | Prostate | BPH | negative regulation of cell-cell adhesion | 46/3107 | 196/18723 | 7.95e-03 | 3.47e-02 | 46 |
GO:00421299 | Prostate | BPH | regulation of T cell proliferation | 41/3107 | 171/18723 | 8.09e-03 | 3.52e-02 | 41 |
GO:00466402 | Prostate | BPH | regulation of alpha-beta T cell proliferation | 12/3107 | 35/18723 | 8.36e-03 | 3.61e-02 | 12 |
GO:19030399 | Prostate | BPH | positive regulation of leukocyte cell-cell adhesion | 54/3107 | 239/18723 | 9.57e-03 | 4.05e-02 | 54 |
GO:00706639 | Prostate | BPH | regulation of leukocyte proliferation | 55/3107 | 245/18723 | 1.02e-02 | 4.29e-02 | 55 |
GO:004209810 | Prostate | BPH | T cell proliferation | 46/3107 | 199/18723 | 1.05e-02 | 4.39e-02 | 46 |
GO:00026859 | Prostate | BPH | regulation of leukocyte migration | 48/3107 | 210/18723 | 1.13e-02 | 4.60e-02 | 48 |
GO:001603219 | Prostate | Tumor | viral process | 155/3246 | 415/18723 | 7.20e-23 | 1.12e-19 | 155 |
GO:001905819 | Prostate | Tumor | viral life cycle | 117/3246 | 317/18723 | 4.10e-17 | 1.18e-14 | 117 |
GO:004440319 | Prostate | Tumor | biological process involved in symbiotic interaction | 99/3246 | 290/18723 | 2.71e-12 | 2.37e-10 | 99 |
GO:005212619 | Prostate | Tumor | movement in host environment | 68/3246 | 175/18723 | 1.06e-11 | 8.21e-10 | 68 |
GO:005170119 | Prostate | Tumor | biological process involved in interaction with host | 75/3246 | 203/18723 | 1.69e-11 | 1.22e-09 | 75 |
GO:004440919 | Prostate | Tumor | entry into host | 58/3246 | 151/18723 | 5.78e-10 | 2.99e-08 | 58 |
GO:004671819 | Prostate | Tumor | viral entry into host cell | 55/3246 | 144/18723 | 2.03e-09 | 8.89e-08 | 55 |
GO:004578519 | Prostate | Tumor | positive regulation of cell adhesion | 125/3246 | 437/18723 | 2.56e-09 | 1.08e-07 | 125 |
GO:000716215 | Prostate | Tumor | negative regulation of cell adhesion | 82/3246 | 303/18723 | 1.38e-05 | 1.89e-04 | 82 |
GO:002240717 | Prostate | Tumor | regulation of cell-cell adhesion | 112/3246 | 448/18723 | 2.20e-05 | 2.80e-04 | 112 |
GO:004211015 | Prostate | Tumor | T cell activation | 117/3246 | 487/18723 | 9.22e-05 | 9.05e-04 | 117 |
GO:003461217 | Prostate | Tumor | response to tumor necrosis factor | 66/3246 | 253/18723 | 2.87e-04 | 2.32e-03 | 66 |
GO:000181914 | Prostate | Tumor | positive regulation of cytokine production | 109/3246 | 467/18723 | 4.98e-04 | 3.67e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Breast | DCIS |
LTA | TNFRSF14 | LTA_TNFRSF14 | LT | Cervix | ADJ |
BTLA | TNFRSF14 | BTLA_TNFRSF14 | BTLA | Cervix | ADJ |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Cervix | CC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Cervix | Healthy |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Cervix | Precancer |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Endometrium | ADJ |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Endometrium | AEH |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Endometrium | Healthy |
LTA | TNFRSF14 | LTA_TNFRSF14 | LT | Esophagus | ADJ |
LTA | TNFRSF14 | LTA_TNFRSF14 | LT | Esophagus | ESCC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Esophagus | ESCC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | HNSCC | ADJ |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | HNSCC | OSCC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Liver | Healthy |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Liver | Precancer |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Lung | AAH |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Prostate | BPH |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Prostate | Tumor |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Skin | cSCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF14 | SNV | Missense_Mutation | c.583G>T | p.Gly195Trp | p.G195W | Q92956 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | |
TNFRSF14 | SNV | Missense_Mutation | novel | c.531G>T | p.Glu177Asp | p.E177D | Q92956 | protein_coding | tolerated(0.23) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF14 | SNV | Missense_Mutation | c.160N>C | p.Cys54Arg | p.C54R | Q92956 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
TNFRSF14 | SNV | Missense_Mutation | rs371087831 | c.785C>T | p.Pro262Leu | p.P262L | Q92956 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF14 | SNV | Missense_Mutation | c.558N>A | p.Ser186Arg | p.S186R | Q92956 | protein_coding | deleterious(0.03) | benign(0.3) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
TNFRSF14 | SNV | Missense_Mutation | c.823T>A | p.Ser275Thr | p.S275T | Q92956 | protein_coding | tolerated(0.76) | benign(0) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNFRSF14 | SNV | Missense_Mutation | c.779C>T | p.Ala260Val | p.A260V | Q92956 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
TNFRSF14 | SNV | Missense_Mutation | novel | c.631N>A | p.Val211Ile | p.V211I | Q92956 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF14 | SNV | Missense_Mutation | novel | c.454N>G | p.Lys152Glu | p.K152E | Q92956 | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF14 | SNV | Missense_Mutation | novel | c.644T>C | p.Val215Ala | p.V215A | Q92956 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8764 | TNFRSF14 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | 178101757 | |||
8764 | TNFRSF14 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | 178101763 | |||
8764 | TNFRSF14 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | 178101591 |
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