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Gene: TMEM5 |
Gene summary for TMEM5 |
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Gene information | Species | Human | Gene symbol | TMEM5 | Gene ID | 10329 |
Gene name | ribitol xylosyltransferase 1 | |
Gene Alias | HP10481 | |
Cytomap | 12q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | G3V1K2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10329 | TMEM5 | P1T-E | Human | Esophagus | ESCC | 6.83e-08 | 4.35e-01 | 0.0875 |
10329 | TMEM5 | P2T-E | Human | Esophagus | ESCC | 1.54e-56 | 1.00e+00 | 0.1177 |
10329 | TMEM5 | P4T-E | Human | Esophagus | ESCC | 1.16e-16 | 4.26e-01 | 0.1323 |
10329 | TMEM5 | P5T-E | Human | Esophagus | ESCC | 2.59e-11 | 2.34e-01 | 0.1327 |
10329 | TMEM5 | P8T-E | Human | Esophagus | ESCC | 8.13e-22 | 4.88e-01 | 0.0889 |
10329 | TMEM5 | P9T-E | Human | Esophagus | ESCC | 5.17e-15 | 2.90e-01 | 0.1131 |
10329 | TMEM5 | P10T-E | Human | Esophagus | ESCC | 1.70e-32 | 5.60e-01 | 0.116 |
10329 | TMEM5 | P11T-E | Human | Esophagus | ESCC | 2.67e-12 | 3.16e-01 | 0.1426 |
10329 | TMEM5 | P12T-E | Human | Esophagus | ESCC | 1.35e-10 | 2.77e-01 | 0.1122 |
10329 | TMEM5 | P15T-E | Human | Esophagus | ESCC | 8.76e-18 | 3.60e-01 | 0.1149 |
10329 | TMEM5 | P16T-E | Human | Esophagus | ESCC | 2.57e-27 | 5.21e-01 | 0.1153 |
10329 | TMEM5 | P19T-E | Human | Esophagus | ESCC | 5.11e-06 | 4.58e-01 | 0.1662 |
10329 | TMEM5 | P20T-E | Human | Esophagus | ESCC | 9.38e-21 | 4.92e-01 | 0.1124 |
10329 | TMEM5 | P21T-E | Human | Esophagus | ESCC | 2.45e-25 | 4.03e-01 | 0.1617 |
10329 | TMEM5 | P22T-E | Human | Esophagus | ESCC | 6.88e-35 | 5.14e-01 | 0.1236 |
10329 | TMEM5 | P23T-E | Human | Esophagus | ESCC | 6.57e-24 | 6.02e-01 | 0.108 |
10329 | TMEM5 | P24T-E | Human | Esophagus | ESCC | 1.05e-15 | 2.40e-01 | 0.1287 |
10329 | TMEM5 | P26T-E | Human | Esophagus | ESCC | 3.17e-23 | 4.70e-01 | 0.1276 |
10329 | TMEM5 | P27T-E | Human | Esophagus | ESCC | 6.41e-13 | 3.45e-01 | 0.1055 |
10329 | TMEM5 | P28T-E | Human | Esophagus | ESCC | 2.93e-17 | 3.83e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19030774 | Colorectum | CRC | negative regulation of protein localization to plasma membrane | 9/2078 | 24/18723 | 6.92e-04 | 9.05e-03 | 9 |
GO:19043763 | Colorectum | CRC | negative regulation of protein localization to cell periphery | 9/2078 | 26/18723 | 1.35e-03 | 1.49e-02 | 9 |
GO:19038283 | Colorectum | CRC | negative regulation of cellular protein localization | 23/2078 | 117/18723 | 4.49e-03 | 3.51e-02 | 23 |
GO:00516044 | Colorectum | CRC | protein maturation | 47/2078 | 294/18723 | 6.52e-03 | 4.70e-02 | 47 |
GO:19054762 | Colorectum | CRC | negative regulation of protein localization to membrane | 9/2078 | 32/18723 | 6.55e-03 | 4.70e-02 | 9 |
GO:000989616 | Endometrium | AEH | positive regulation of catabolic process | 104/2100 | 492/18723 | 9.38e-11 | 1.10e-08 | 104 |
GO:003133116 | Endometrium | AEH | positive regulation of cellular catabolic process | 91/2100 | 427/18723 | 9.15e-10 | 8.31e-08 | 91 |
GO:007265914 | Endometrium | AEH | protein localization to plasma membrane | 63/2100 | 284/18723 | 7.58e-08 | 3.92e-06 | 63 |
GO:19907789 | Endometrium | AEH | protein localization to cell periphery | 68/2100 | 333/18723 | 6.38e-07 | 2.38e-05 | 68 |
GO:004586116 | Endometrium | AEH | negative regulation of proteolysis | 63/2100 | 351/18723 | 1.07e-04 | 1.53e-03 | 63 |
GO:19054759 | Endometrium | AEH | regulation of protein localization to membrane | 34/2100 | 175/18723 | 9.62e-04 | 8.75e-03 | 34 |
GO:00105068 | Endometrium | AEH | regulation of autophagy | 54/2100 | 317/18723 | 1.15e-03 | 9.97e-03 | 54 |
GO:00105085 | Endometrium | AEH | positive regulation of autophagy | 26/2100 | 124/18723 | 1.17e-03 | 1.01e-02 | 26 |
GO:19030769 | Endometrium | AEH | regulation of protein localization to plasma membrane | 22/2100 | 104/18723 | 2.40e-03 | 1.80e-02 | 22 |
GO:19043759 | Endometrium | AEH | regulation of protein localization to cell periphery | 25/2100 | 125/18723 | 2.84e-03 | 2.04e-02 | 25 |
GO:00070348 | Endometrium | AEH | vacuolar transport | 29/2100 | 157/18723 | 4.69e-03 | 2.99e-02 | 29 |
GO:00325094 | Endometrium | AEH | endosome transport via multivesicular body sorting pathway | 9/2100 | 31/18723 | 5.59e-03 | 3.44e-02 | 9 |
GO:000989617 | Endometrium | EEC | positive regulation of catabolic process | 108/2168 | 492/18723 | 2.55e-11 | 3.64e-09 | 108 |
GO:003133117 | Endometrium | EEC | positive regulation of cellular catabolic process | 94/2168 | 427/18723 | 4.30e-10 | 4.45e-08 | 94 |
GO:007265915 | Endometrium | EEC | protein localization to plasma membrane | 64/2168 | 284/18723 | 1.05e-07 | 5.05e-06 | 64 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM5 | SNV | Missense_Mutation | novel | c.1220N>C | p.Lys407Thr | p.K407T | Q9Y2B1 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM5 | SNV | Missense_Mutation | c.287N>T | p.Thr96Ile | p.T96I | Q9Y2B1 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
TMEM5 | SNV | Missense_Mutation | novel | c.739G>A | p.Ala247Thr | p.A247T | Q9Y2B1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM5 | SNV | Missense_Mutation | novel | c.239G>A | p.Arg80Lys | p.R80K | Q9Y2B1 | protein_coding | tolerated(0.38) | benign(0.009) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM5 | SNV | Missense_Mutation | rs570064856 | c.154G>C | p.Glu52Gln | p.E52Q | Q9Y2B1 | protein_coding | tolerated(0.39) | benign(0.221) | TCGA-VS-A9UU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM5 | SNV | Missense_Mutation | c.559N>G | p.Leu187Val | p.L187V | Q9Y2B1 | protein_coding | deleterious(0) | possibly_damaging(0.861) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM5 | SNV | Missense_Mutation | c.559N>G | p.Leu187Val | p.L187V | Q9Y2B1 | protein_coding | deleterious(0) | possibly_damaging(0.861) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TMEM5 | SNV | Missense_Mutation | novel | c.724N>C | p.Trp242Arg | p.W242R | Q9Y2B1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM5 | SNV | Missense_Mutation | novel | c.1133N>T | p.Ser378Phe | p.S378F | Q9Y2B1 | protein_coding | deleterious(0.02) | possibly_damaging(0.568) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM5 | SNV | Missense_Mutation | novel | c.316G>A | p.Ala106Thr | p.A106T | Q9Y2B1 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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