Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SAFB_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SAFB_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SAFB_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SAFB_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SAFB_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SAFB_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SAFB_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007138325 | Oral cavity | EOLP | cellular response to steroid hormone stimulus | 49/2218 | 204/18723 | 8.63e-07 | 2.15e-05 | 49 |
GO:003051824 | Oral cavity | EOLP | intracellular steroid hormone receptor signaling pathway | 29/2218 | 116/18723 | 6.49e-05 | 8.10e-04 | 29 |
GO:004340123 | Oral cavity | EOLP | steroid hormone mediated signaling pathway | 32/2218 | 136/18723 | 9.85e-05 | 1.14e-03 | 32 |
GO:000975510 | Oral cavity | EOLP | hormone-mediated signaling pathway | 36/2218 | 190/18723 | 2.87e-03 | 1.70e-02 | 36 |
GO:003052022 | Oral cavity | EOLP | intracellular estrogen receptor signaling pathway | 13/2218 | 54/18723 | 9.03e-03 | 4.14e-02 | 13 |
GO:190331133 | Oral cavity | NEOLP | regulation of mRNA metabolic process | 91/2005 | 288/18723 | 2.65e-22 | 7.88e-19 | 91 |
GO:005068433 | Oral cavity | NEOLP | regulation of mRNA processing | 56/2005 | 137/18723 | 4.37e-20 | 6.48e-17 | 56 |
GO:006145831 | Oral cavity | NEOLP | reproductive system development | 91/2005 | 427/18723 | 8.18e-11 | 9.00e-09 | 91 |
GO:004860831 | Oral cavity | NEOLP | reproductive structure development | 90/2005 | 424/18723 | 1.30e-10 | 1.33e-08 | 90 |
GO:003052231 | Oral cavity | NEOLP | intracellular receptor signaling pathway | 61/2005 | 265/18723 | 5.22e-09 | 2.87e-07 | 61 |
GO:004854532 | Oral cavity | NEOLP | response to steroid hormone | 64/2005 | 339/18723 | 4.45e-06 | 9.55e-05 | 64 |
GO:007138331 | Oral cavity | NEOLP | cellular response to steroid hormone stimulus | 42/2005 | 204/18723 | 2.34e-05 | 3.73e-04 | 42 |
GO:000632521 | Oral cavity | NEOLP | chromatin organization | 70/2005 | 409/18723 | 4.97e-05 | 6.83e-04 | 70 |
GO:003051831 | Oral cavity | NEOLP | intracellular steroid hormone receptor signaling pathway | 27/2005 | 116/18723 | 7.54e-05 | 9.71e-04 | 27 |
GO:004340131 | Oral cavity | NEOLP | steroid hormone mediated signaling pathway | 29/2005 | 136/18723 | 2.17e-04 | 2.29e-03 | 29 |
GO:00600082 | Oral cavity | NEOLP | Sertoli cell differentiation | 8/2005 | 18/18723 | 2.78e-04 | 2.79e-03 | 8 |
GO:003052123 | Oral cavity | NEOLP | androgen receptor signaling pathway | 13/2005 | 44/18723 | 4.99e-04 | 4.42e-03 | 13 |
GO:000975515 | Oral cavity | NEOLP | hormone-mediated signaling pathway | 33/2005 | 190/18723 | 3.53e-03 | 2.07e-02 | 33 |
GO:190331116 | Prostate | BPH | regulation of mRNA metabolic process | 111/3107 | 288/18723 | 2.28e-19 | 1.17e-16 | 111 |
GO:005068415 | Prostate | BPH | regulation of mRNA processing | 64/3107 | 137/18723 | 1.73e-16 | 3.82e-14 | 64 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAFB | SNV | Missense_Mutation | rs770745797 | c.502N>A | p.Glu168Lys | p.E168K | Q15424 | protein_coding | tolerated(0.39) | benign(0.372) | TCGA-AC-A7VC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAFB | SNV | Missense_Mutation | | c.2311N>T | p.Met771Leu | p.M771L | Q15424 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAFB | SNV | Missense_Mutation | | c.1825N>G | p.Lys609Glu | p.K609E | Q15424 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAFB | SNV | Missense_Mutation | | c.1534N>G | p.Asn512Asp | p.N512D | Q15424 | protein_coding | tolerated(0.45) | benign(0.029) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SAFB | SNV | Missense_Mutation | | c.1471A>T | p.Thr491Ser | p.T491S | Q15424 | protein_coding | tolerated(0.61) | benign(0.017) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
SAFB | insertion | Frame_Shift_Ins | novel | c.2290_2291insTGAGACTC | p.Arg764MetfsTer11 | p.R764Mfs*11 | Q15424 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SAFB | insertion | Frame_Shift_Ins | novel | c.2330_2331insAT | p.Gln778TyrfsTer31 | p.Q778Yfs*31 | Q15424 | protein_coding | | | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SAFB | insertion | Nonsense_Mutation | novel | c.2332_2333insAATGCAACTTCTATAAAGGGCCTTGTAAACTGTTCT | p.Gln778_His779insCysAsnPheTyrLysGlyProCysLysLeuPheTer | p.Q778_H779insCNFYKGPCKLF* | Q15424 | protein_coding | | | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SAFB | insertion | Frame_Shift_Ins | novel | c.178_179insTTTTCAACAAACCAACAAAAAAATGCAATACCCATCTAGTAACCAAA | p.Arg60LeufsTer18 | p.R60Lfs*18 | Q15424 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
SAFB | deletion | Frame_Shift_Del | novel | c.602delN | p.Ile201AsnfsTer30 | p.I201Nfs*30 | Q15424 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |