Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RPL7L1

Gene summary for RPL7L1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RPL7L1

Gene ID

285855

Gene nameribosomal protein L7 like 1
Gene AliasdJ475N16.4
Cytomap6p21.1
Gene Typeprotein-coding
GO ID

GO:0000463

UniProtAcc

A0A024RD36


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
285855RPL7L1HTA11_1938_2000001011HumanColorectumAD3.19e-095.62e-01-0.0811
285855RPL7L1HTA11_78_2000001011HumanColorectumAD3.91e-053.59e-01-0.1088
285855RPL7L1HTA11_347_2000001011HumanColorectumAD7.28e-125.08e-01-0.1954
285855RPL7L1HTA11_83_2000001011HumanColorectumSER8.26e-084.90e-01-0.1526
285855RPL7L1HTA11_696_2000001011HumanColorectumAD2.20e-023.38e-01-0.1464
285855RPL7L1HTA11_1391_2000001011HumanColorectumAD6.94e-115.38e-01-0.059
285855RPL7L1HTA11_866_3004761011HumanColorectumAD8.85e-032.82e-010.096
285855RPL7L1HTA11_7663_2000001011HumanColorectumSER1.99e-045.94e-010.0131
285855RPL7L1HTA11_7696_3000711011HumanColorectumAD7.73e-094.07e-010.0674
285855RPL7L1HTA11_99999965062_69753HumanColorectumMSI-H7.11e-051.16e+000.3487
285855RPL7L1HTA11_99999965104_69814HumanColorectumMSS6.57e-157.82e-010.281
285855RPL7L1HTA11_99999971662_82457HumanColorectumMSS2.70e-177.04e-010.3859
285855RPL7L1HTA11_99999973899_84307HumanColorectumMSS6.07e-034.32e-010.2585
285855RPL7L1HTA11_99999974143_84620HumanColorectumMSS1.48e-053.60e-010.3005
285855RPL7L1A015-C-203HumanColorectumFAP1.38e-03-3.24e-02-0.1294
285855RPL7L1A015-C-104HumanColorectumFAP2.71e-042.70e-03-0.1899
285855RPL7L1AEH-subject1HumanEndometriumAEH1.79e-22-3.74e-01-0.3059
285855RPL7L1AEH-subject2HumanEndometriumAEH4.43e-05-2.72e-01-0.2525
285855RPL7L1AEH-subject3HumanEndometriumAEH3.53e-14-2.86e-01-0.2576
285855RPL7L1AEH-subject4HumanEndometriumAEH2.35e-07-3.31e-01-0.2657
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004225427SkinAKribosome biogenesis73/1910299/187238.44e-132.08e-1073
GO:000170120SkinAKin utero embryonic development75/1910367/187233.09e-092.62e-0775
GO:000636420SkinAKrRNA processing53/1910225/187234.35e-093.30e-0753
GO:001607220SkinAKrRNA metabolic process54/1910236/187239.23e-096.07e-0754
GO:004227327SkinAKribosomal large subunit biogenesis24/191072/187238.63e-084.02e-0624
GO:003447016SkinAKncRNA processing68/1910395/187231.12e-052.33e-0468
GO:00018245SkinAKblastocyst development24/1910106/187231.38e-041.69e-0324
GO:00346607SkinAKncRNA metabolic process75/1910485/187231.64e-041.93e-0375
GO:00018254SkinAKblastocyst formation12/191038/187232.64e-042.85e-0312
GO:00004708SkinAKmaturation of LSU-rRNA8/191028/187235.55e-033.05e-028
GO:002261329SkincSCCribonucleoprotein complex biogenesis302/4864463/187235.13e-723.22e-68302
GO:004225428SkincSCCribosome biogenesis206/4864299/187233.33e-551.04e-51206
GO:000636424SkincSCCrRNA processing156/4864225/187231.42e-421.48e-39156
GO:001607224SkincSCCrRNA metabolic process158/4864236/187234.06e-402.83e-37158
GO:003447017SkincSCCncRNA processing215/4864395/187236.83e-344.28e-31215
GO:003466013SkincSCCncRNA metabolic process234/4864485/187231.37e-264.77e-24234
GO:004227328SkincSCCribosomal large subunit biogenesis57/486472/187234.90e-218.53e-1957
GO:000170124SkincSCCin utero embryonic development150/4864367/187232.47e-101.04e-08150
GO:000047022SkincSCCmaturation of LSU-rRNA22/486428/187238.75e-092.76e-0722
GO:000182413SkincSCCblastocyst development53/4864106/187239.74e-082.32e-0653
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RPL7L1SNVMissense_Mutationc.341G>Tp.Arg114Ilep.R114IQ6DKI1protein_codingdeleterious(0)possibly_damaging(0.495)TCGA-IR-A3LA-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RPL7L1SNVMissense_Mutationc.494G>Cp.Gly165Alap.G165AQ6DKI1protein_codingdeleterious(0.01)possibly_damaging(0.782)TCGA-JX-A3Q0-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
RPL7L1SNVMissense_Mutationnovelc.270N>Cp.Leu90Phep.L90FQ6DKI1protein_codingdeleterious(0.04)benign(0.361)TCGA-VS-A94Z-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RPL7L1SNVMissense_Mutationnovelc.372N>Gp.Ile124Metp.I124MQ6DKI1protein_codingdeleterious(0.02)benign(0.277)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
RPL7L1SNVMissense_Mutationnovelc.230G>Cp.Arg77Prop.R77PQ6DKI1protein_codingdeleterious(0.01)possibly_damaging(0.809)TCGA-AM-5820-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
RPL7L1SNVMissense_Mutationrs377107940c.422N>Ap.Arg141Hisp.R141HQ6DKI1protein_codingtolerated(0.06)benign(0.021)TCGA-AZ-4313-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
RPL7L1insertionFrame_Shift_Insnovelc.397_398insCp.Gln135ProfsTer38p.Q135Pfs*38Q6DKI1protein_codingTCGA-AA-3877-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
RPL7L1deletionFrame_Shift_Delnovelc.233delTp.Leu78ProfsTer4p.L78Pfs*4Q6DKI1protein_codingTCGA-AM-5820-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
RPL7L1SNVMissense_Mutationrs191520270c.301N>Tp.Arg101Cysp.R101CQ6DKI1protein_codingtolerated(0.06)benign(0.031)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
RPL7L1SNVMissense_Mutationc.630N>Cp.Glu210Aspp.E210DQ6DKI1protein_codingtolerated(0.09)benign(0.005)TCGA-AJ-A3BD-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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