Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RIN1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RIN1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RIN1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RIN1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190274311 | Liver | Cirrhotic | regulation of lamellipodium organization | 25/4634 | 54/18723 | 4.63e-04 | 3.75e-03 | 25 |
GO:00107205 | Liver | Cirrhotic | positive regulation of cell development | 99/4634 | 298/18723 | 5.71e-04 | 4.46e-03 | 99 |
GO:00482461 | Liver | Cirrhotic | macrophage chemotaxis | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:1905521 | Liver | Cirrhotic | regulation of macrophage migration | 20/4634 | 41/18723 | 7.37e-04 | 5.44e-03 | 20 |
GO:00105915 | Liver | Cirrhotic | regulation of lamellipodium assembly | 20/4634 | 42/18723 | 1.08e-03 | 7.54e-03 | 20 |
GO:003003211 | Liver | Cirrhotic | lamellipodium assembly | 30/4634 | 72/18723 | 1.18e-03 | 7.98e-03 | 30 |
GO:19055171 | Liver | Cirrhotic | macrophage migration | 24/4634 | 55/18723 | 1.67e-03 | 1.07e-02 | 24 |
GO:0010758 | Liver | Cirrhotic | regulation of macrophage chemotaxis | 14/4634 | 27/18723 | 2.20e-03 | 1.35e-02 | 14 |
GO:00321032 | Liver | Cirrhotic | positive regulation of response to external stimulus | 131/4634 | 427/18723 | 2.90e-03 | 1.66e-02 | 131 |
GO:01200326 | Liver | Cirrhotic | regulation of plasma membrane bounded cell projection assembly | 63/4634 | 186/18723 | 3.16e-03 | 1.78e-02 | 63 |
GO:00604915 | Liver | Cirrhotic | regulation of cell projection assembly | 63/4634 | 188/18723 | 4.17e-03 | 2.22e-02 | 63 |
GO:1905523 | Liver | Cirrhotic | positive regulation of macrophage migration | 13/4634 | 26/18723 | 4.72e-03 | 2.48e-02 | 13 |
GO:00026904 | Liver | Cirrhotic | positive regulation of leukocyte chemotaxis | 35/4634 | 94/18723 | 4.75e-03 | 2.49e-02 | 35 |
GO:00026876 | Liver | Cirrhotic | positive regulation of leukocyte migration | 47/4634 | 135/18723 | 5.55e-03 | 2.81e-02 | 47 |
GO:00026886 | Liver | Cirrhotic | regulation of leukocyte chemotaxis | 42/4634 | 122/18723 | 1.04e-02 | 4.62e-02 | 42 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:001076922 | Liver | HCC | regulation of cell morphogenesis involved in differentiation | 65/7958 | 96/18723 | 5.17e-07 | 8.37e-06 | 65 |
GO:003134611 | Liver | HCC | positive regulation of cell projection organization | 193/7958 | 353/18723 | 2.28e-06 | 3.08e-05 | 193 |
GO:001077022 | Liver | HCC | positive regulation of cell morphogenesis involved in differentiation | 53/7958 | 79/18723 | 8.69e-06 | 1.02e-04 | 53 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIN1 | SNV | Missense_Mutation | novel | c.1624N>G | p.Leu542Val | p.L542V | Q13671 | protein_coding | tolerated(0.46) | benign(0.19) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
RIN1 | SNV | Missense_Mutation | novel | c.2022N>A | p.Phe674Leu | p.F674L | Q13671 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-A1-A0SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIN1 | SNV | Missense_Mutation | | c.73C>G | p.Leu25Val | p.L25V | Q13671 | protein_coding | tolerated_low_confidence(0.1) | benign(0.069) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RIN1 | SNV | Missense_Mutation | novel | c.1291G>A | p.Val431Ile | p.V431I | Q13671 | protein_coding | tolerated(0.24) | benign(0.005) | TCGA-AO-A03V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
RIN1 | SNV | Missense_Mutation | | c.803N>G | p.Pro268Arg | p.P268R | Q13671 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-D8-A27T-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
RIN1 | SNV | Missense_Mutation | rs62619978 | c.2245N>T | p.Arg749Trp | p.R749W | Q13671 | protein_coding | deleterious_low_confidence(0.03) | benign(0.183) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
RIN1 | insertion | Nonsense_Mutation | novel | c.1822_1823insCATAGCTGCATCCAAAAGAGGCCCAGGTCATCTAACCTAAGGAGAAT | p.Arg608ProfsTer2 | p.R608Pfs*2 | Q13671 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
RIN1 | insertion | Frame_Shift_Ins | novel | c.1770_1771insACTTGTTTTTGCTTCTCCTCCTGCATAGCACCTCCTCCGAGTAG | p.Gly591ThrfsTer25 | p.G591Tfs*25 | Q13671 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
RIN1 | insertion | Nonsense_Mutation | novel | c.1770_1771insAATAGGACCTACCTCCTGGGGTTGAGGTGAAGATTAAATG | p.Gly591AsnfsTer10 | p.G591Nfs*10 | Q13671 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
RIN1 | SNV | Missense_Mutation | novel | c.1922N>T | p.Ser641Phe | p.S641F | Q13671 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |