Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RBM22_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RBM22_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RBM22_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RBM22_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RBM22_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00511709 | Oral cavity | OSCC | import into nucleus | 100/7305 | 159/18723 | 8.67e-10 | 2.15e-08 | 100 |
GO:00066069 | Oral cavity | OSCC | protein import into nucleus | 97/7305 | 155/18723 | 2.27e-09 | 5.30e-08 | 97 |
GO:004682414 | Oral cavity | OSCC | positive regulation of nucleocytoplasmic transport | 45/7305 | 62/18723 | 8.26e-08 | 1.46e-06 | 45 |
GO:004682518 | Oral cavity | OSCC | regulation of protein export from nucleus | 26/7305 | 30/18723 | 9.63e-08 | 1.66e-06 | 26 |
GO:00066119 | Oral cavity | OSCC | protein export from nucleus | 42/7305 | 57/18723 | 1.10e-07 | 1.87e-06 | 42 |
GO:003312018 | Oral cavity | OSCC | positive regulation of RNA splicing | 29/7305 | 37/18723 | 1.21e-06 | 1.61e-05 | 29 |
GO:19045899 | Oral cavity | OSCC | regulation of protein import | 43/7305 | 63/18723 | 2.43e-06 | 3.06e-05 | 43 |
GO:19045918 | Oral cavity | OSCC | positive regulation of protein import | 31/7305 | 43/18723 | 1.10e-05 | 1.14e-04 | 31 |
GO:00423068 | Oral cavity | OSCC | regulation of protein import into nucleus | 40/7305 | 60/18723 | 1.32e-05 | 1.33e-04 | 40 |
GO:00423078 | Oral cavity | OSCC | positive regulation of protein import into nucleus | 29/7305 | 41/18723 | 3.81e-05 | 3.37e-04 | 29 |
GO:000941018 | Oral cavity | OSCC | response to xenobiotic stimulus | 222/7305 | 462/18723 | 4.00e-05 | 3.48e-04 | 222 |
GO:00468279 | Oral cavity | OSCC | positive regulation of protein export from nucleus | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:004348434 | Oral cavity | NEOLP | regulation of RNA splicing | 61/2005 | 148/18723 | 5.56e-22 | 1.10e-18 | 61 |
GO:000838033 | Oral cavity | NEOLP | RNA splicing | 110/2005 | 434/18723 | 2.29e-18 | 2.72e-15 | 110 |
GO:000037733 | Oral cavity | NEOLP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 81/2005 | 320/18723 | 7.96e-14 | 2.63e-11 | 81 |
GO:000039833 | Oral cavity | NEOLP | mRNA splicing, via spliceosome | 81/2005 | 320/18723 | 7.96e-14 | 2.63e-11 | 81 |
GO:000037533 | Oral cavity | NEOLP | RNA splicing, via transesterification reactions | 81/2005 | 324/18723 | 1.64e-13 | 5.13e-11 | 81 |
GO:004682231 | Oral cavity | NEOLP | regulation of nucleocytoplasmic transport | 39/2005 | 106/18723 | 1.14e-12 | 2.60e-10 | 39 |
GO:000691331 | Oral cavity | NEOLP | nucleocytoplasmic transport | 75/2005 | 301/18723 | 1.56e-12 | 3.20e-10 | 75 |
GO:005116931 | Oral cavity | NEOLP | nuclear transport | 75/2005 | 301/18723 | 1.56e-12 | 3.20e-10 | 75 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM22 | SNV | Missense_Mutation | | c.616A>G | p.Asn206Asp | p.N206D | Q9NW64 | protein_coding | deleterious(0.04) | benign(0.038) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
RBM22 | insertion | Nonsense_Mutation | novel | c.384_385insTGGTATTAGGTCTATTTTGGTAATTATATTTTG | p.Ser128_Asp129insTrpTyrTerValTyrPheGlyAsnTyrIleLeu | p.S128_D129insWY*VYFGNYIL | Q9NW64 | protein_coding | | | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
RBM22 | insertion | Frame_Shift_Ins | novel | c.369_370insTTTCATAGTTCTAAGACAT | p.Glu124PhefsTer7 | p.E124Ffs*7 | Q9NW64 | protein_coding | | | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM22 | deletion | Frame_Shift_Del | novel | c.696delN | p.Thr233HisfsTer7 | p.T233Hfs*7 | Q9NW64 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RBM22 | SNV | Missense_Mutation | novel | c.836C>T | p.Ala279Val | p.A279V | Q9NW64 | protein_coding | deleterious(0.02) | possibly_damaging(0.734) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RBM22 | SNV | Missense_Mutation | rs755478465 | c.191N>A | p.Arg64His | p.R64H | Q9NW64 | protein_coding | tolerated(0.11) | probably_damaging(0.999) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RBM22 | SNV | Missense_Mutation | | c.959A>G | p.Asp320Gly | p.D320G | Q9NW64 | protein_coding | tolerated(0.17) | benign(0.031) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM22 | SNV | Missense_Mutation | | c.602N>A | p.Arg201His | p.R201H | Q9NW64 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RBM22 | SNV | Missense_Mutation | | c.125G>T | p.Gly42Val | p.G42V | Q9NW64 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
RBM22 | SNV | Missense_Mutation | | c.391N>G | p.Thr131Ala | p.T131A | Q9NW64 | protein_coding | tolerated(0.33) | benign(0.017) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |