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Gene: PXN |
Gene summary for PXN |
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Gene information | Species | Human | Gene symbol | PXN | Gene ID | 5829 |
Gene name | paxillin | |
Gene Alias | PXN | |
Cytomap | 12q24.23 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | A0A140VJQ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5829 | PXN | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.83e-03 | 3.82e-01 | -0.1808 |
5829 | PXN | HTA11_78_2000001011 | Human | Colorectum | AD | 3.93e-03 | 3.77e-01 | -0.1088 |
5829 | PXN | HTA11_347_2000001011 | Human | Colorectum | AD | 3.51e-14 | 5.84e-01 | -0.1954 |
5829 | PXN | HTA11_696_2000001011 | Human | Colorectum | AD | 7.69e-04 | 3.13e-01 | -0.1464 |
5829 | PXN | HTA11_866_2000001011 | Human | Colorectum | AD | 1.05e-02 | 2.92e-01 | -0.1001 |
5829 | PXN | A015-C-203 | Human | Colorectum | FAP | 4.49e-04 | -9.19e-02 | -0.1294 |
5829 | PXN | A002-C-205 | Human | Colorectum | FAP | 2.26e-05 | -2.33e-01 | -0.1236 |
5829 | PXN | A015-C-104 | Human | Colorectum | FAP | 4.73e-06 | -1.07e-01 | -0.1899 |
5829 | PXN | A002-C-016 | Human | Colorectum | FAP | 8.81e-06 | -1.80e-01 | 0.0521 |
5829 | PXN | A002-C-116 | Human | Colorectum | FAP | 3.78e-11 | -2.04e-01 | -0.0452 |
5829 | PXN | F034 | Human | Colorectum | FAP | 2.87e-05 | -1.85e-01 | -0.0665 |
5829 | PXN | F072B | Human | Colorectum | FAP | 2.94e-03 | -1.77e-01 | 0.257 |
5829 | PXN | LZE4T | Human | Esophagus | ESCC | 4.28e-08 | -1.01e-01 | 0.0811 |
5829 | PXN | LZE7T | Human | Esophagus | ESCC | 2.23e-04 | -9.42e-03 | 0.0667 |
5829 | PXN | LZE8T | Human | Esophagus | ESCC | 8.23e-05 | 2.36e-02 | 0.067 |
5829 | PXN | LZE20T | Human | Esophagus | ESCC | 4.81e-04 | -8.51e-02 | 0.0662 |
5829 | PXN | LZE22D1 | Human | Esophagus | HGIN | 6.59e-03 | -9.25e-02 | 0.0595 |
5829 | PXN | LZE24T | Human | Esophagus | ESCC | 9.31e-10 | 1.76e-02 | 0.0596 |
5829 | PXN | LZE6T | Human | Esophagus | ESCC | 3.02e-02 | 1.31e-01 | 0.0845 |
5829 | PXN | P2T-E | Human | Esophagus | ESCC | 1.24e-25 | 5.04e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902905111 | Esophagus | ESCC | positive regulation of supramolecular fiber organization | 142/8552 | 209/18723 | 5.51e-11 | 1.76e-09 | 142 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:003158919 | Esophagus | ESCC | cell-substrate adhesion | 221/8552 | 363/18723 | 3.06e-09 | 6.62e-08 | 221 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:011005327 | Esophagus | ESCC | regulation of actin filament organization | 166/8552 | 278/18723 | 1.54e-06 | 1.85e-05 | 166 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:00715609 | Esophagus | ESCC | cellular response to transforming growth factor beta stimulus | 151/8552 | 250/18723 | 1.78e-06 | 2.10e-05 | 151 |
GO:000716018 | Esophagus | ESCC | cell-matrix adhesion | 141/8552 | 233/18723 | 3.33e-06 | 3.71e-05 | 141 |
GO:005101727 | Esophagus | ESCC | actin filament bundle assembly | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:00071799 | Esophagus | ESCC | transforming growth factor beta receptor signaling pathway | 121/8552 | 198/18723 | 8.26e-06 | 8.03e-05 | 121 |
GO:006157227 | Esophagus | ESCC | actin filament bundle organization | 101/8552 | 161/18723 | 9.22e-06 | 8.82e-05 | 101 |
GO:007137516 | Esophagus | ESCC | cellular response to peptide hormone stimulus | 166/8552 | 290/18723 | 4.48e-05 | 3.55e-04 | 166 |
GO:003003820 | Esophagus | ESCC | contractile actin filament bundle assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:004314920 | Esophagus | ESCC | stress fiber assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa05205 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa052051 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PXN | insertion | Nonsense_Mutation | novel | c.1223_1224insTGTGTGAGAACTAAATGAGATAATGC | p.Asn409ValfsTer2 | p.N409Vfs*2 | P49023 | protein_coding | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PXN | SNV | Missense_Mutation | rs201427575 | c.1127N>G | p.Lys376Arg | p.K376R | P49023 | protein_coding | tolerated(0.07) | benign(0.022) | TCGA-EA-A3HR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PXN | SNV | Missense_Mutation | novel | c.1346N>T | p.Thr449Met | p.T449M | P49023 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PXN | SNV | Missense_Mutation | novel | c.1185C>G | p.His395Gln | p.H395Q | P49023 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PXN | SNV | Missense_Mutation | c.1067A>G | p.Gln356Arg | p.Q356R | P49023 | protein_coding | deleterious(0.02) | probably_damaging(0.948) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PXN | SNV | Missense_Mutation | c.742N>A | p.Val248Ile | p.V248I | P49023 | protein_coding | tolerated(0.35) | benign(0.236) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
PXN | SNV | Missense_Mutation | rs766354430 | c.1189N>A | p.Val397Ile | p.V397I | P49023 | protein_coding | tolerated(0.07) | benign(0.428) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PXN | SNV | Missense_Mutation | c.1618C>T | p.His540Tyr | p.H540Y | P49023 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PXN | SNV | Missense_Mutation | c.1602N>T | p.Gln534His | p.Q534H | P49023 | protein_coding | deleterious(0.02) | benign(0.236) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PXN | SNV | Missense_Mutation | rs748821995 | c.16N>A | p.Ala6Thr | p.A6T | P49023 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5829 | PXN | NA | H2O2 | 9590268 | ||
5829 | PXN | NA | 1,2,4,5-BENZENETETRAAMINE TETRAHYDROCHLORIDE | CHEMBL456559 | 18989950 | |
5829 | PXN | NA | ANTISENSE OLIGONUCLEOTIDES | 14576084 | ||
5829 | PXN | NA | LOVASTATIN | LOVASTATIN | 11581207 |
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