Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PLS1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PLS1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PLS1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/PLS1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PLS1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0040014 | Colorectum | FAP | regulation of multicellular organism growth | 16/2622 | 61/18723 | 8.38e-03 | 4.89e-02 | 16 |
GO:00226002 | Colorectum | FAP | digestive system process | 24/2622 | 104/18723 | 8.41e-03 | 4.89e-02 | 24 |
GO:00508922 | Colorectum | FAP | intestinal absorption | 12/2622 | 41/18723 | 8.57e-03 | 4.96e-02 | 12 |
GO:00726595 | Colorectum | CRC | protein localization to plasma membrane | 80/2078 | 284/18723 | 1.36e-15 | 4.07e-12 | 80 |
GO:00070155 | Colorectum | CRC | actin filament organization | 104/2078 | 442/18723 | 4.75e-14 | 7.12e-11 | 104 |
GO:19907785 | Colorectum | CRC | protein localization to cell periphery | 85/2078 | 333/18723 | 8.75e-14 | 1.05e-10 | 85 |
GO:00020645 | Colorectum | CRC | epithelial cell development | 55/2078 | 220/18723 | 4.63e-09 | 1.16e-06 | 55 |
GO:00325354 | Colorectum | CRC | regulation of cellular component size | 79/2078 | 383/18723 | 3.30e-08 | 4.60e-06 | 79 |
GO:19043754 | Colorectum | CRC | regulation of protein localization to cell periphery | 36/2078 | 125/18723 | 4.62e-08 | 5.91e-06 | 36 |
GO:19054754 | Colorectum | CRC | regulation of protein localization to membrane | 45/2078 | 175/18723 | 4.64e-08 | 5.91e-06 | 45 |
GO:19038295 | Colorectum | CRC | positive regulation of cellular protein localization | 61/2078 | 276/18723 | 9.59e-08 | 1.17e-05 | 61 |
GO:19030764 | Colorectum | CRC | regulation of protein localization to plasma membrane | 31/2078 | 104/18723 | 1.66e-07 | 1.72e-05 | 31 |
GO:01060274 | Colorectum | CRC | neuron projection organization | 28/2078 | 93/18723 | 5.17e-07 | 3.73e-05 | 28 |
GO:00615724 | Colorectum | CRC | actin filament bundle organization | 40/2078 | 161/18723 | 6.72e-07 | 4.52e-05 | 40 |
GO:00510174 | Colorectum | CRC | actin filament bundle assembly | 39/2078 | 157/18723 | 9.26e-07 | 5.83e-05 | 39 |
GO:00486383 | Colorectum | CRC | regulation of developmental growth | 64/2078 | 330/18723 | 5.74e-06 | 2.26e-04 | 64 |
GO:19054774 | Colorectum | CRC | positive regulation of protein localization to membrane | 28/2078 | 106/18723 | 8.84e-06 | 3.11e-04 | 28 |
GO:00459274 | Colorectum | CRC | positive regulation of growth | 51/2078 | 259/18723 | 3.23e-05 | 8.27e-04 | 51 |
GO:19043774 | Colorectum | CRC | positive regulation of protein localization to cell periphery | 20/2078 | 69/18723 | 3.92e-05 | 9.54e-04 | 20 |
GO:00308664 | Colorectum | CRC | cortical actin cytoskeleton organization | 14/2078 | 40/18723 | 5.81e-05 | 1.31e-03 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLS1 | SNV | Missense_Mutation | | c.1849N>C | p.Phe617Leu | p.F617L | Q14651 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLS1 | SNV | Missense_Mutation | | c.1712N>A | p.Arg571Lys | p.R571K | Q14651 | protein_coding | tolerated(1) | benign(0) | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD |
PLS1 | SNV | Missense_Mutation | rs773749532 | c.1526C>T | p.Ser509Leu | p.S509L | Q14651 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
PLS1 | SNV | Missense_Mutation | novel | c.605N>G | p.Ser202Cys | p.S202C | Q14651 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PLS1 | insertion | Frame_Shift_Ins | novel | c.1245_1246insAAAAA | p.His416LysfsTer12 | p.H416Kfs*12 | Q14651 | protein_coding | | | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PLS1 | insertion | In_Frame_Ins | novel | c.1246_1247insAAA | p.His416delinsGlnAsn | p.H416delinsQN | Q14651 | protein_coding | | | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PLS1 | insertion | Nonsense_Mutation | novel | c.1534_1535insGAGAGGGGTAATGTTCATTTTATGATACAGATCTCTGGGCAGGGGTAAGAGA | p.Glu515Ter | p.E515* | Q14651 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PLS1 | SNV | Missense_Mutation | | c.233N>T | p.Ser78Leu | p.S78L | Q14651 | protein_coding | tolerated(0.07) | benign(0.272) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
PLS1 | SNV | Missense_Mutation | | c.1515N>C | p.Leu505Phe | p.L505F | Q14651 | protein_coding | deleterious(0.03) | possibly_damaging(0.521) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLS1 | SNV | Missense_Mutation | | c.529N>C | p.Ile177Leu | p.I177L | Q14651 | protein_coding | deleterious(0) | benign(0.179) | TCGA-IR-A3LC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | Complete Response |