GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00706131 | Liver | HCC | regulation of protein processing | 37/7958 | 65/18723 | 1.33e-02 | 4.77e-02 | 37 |
GO:004586220 | Oral cavity | OSCC | positive regulation of proteolysis | 236/7305 | 372/18723 | 6.53e-22 | 1.38e-19 | 236 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00164856 | Oral cavity | OSCC | protein processing | 121/7305 | 225/18723 | 4.56e-06 | 5.23e-05 | 121 |
GO:19033172 | Oral cavity | OSCC | regulation of protein maturation | 36/7305 | 67/18723 | 1.01e-02 | 3.51e-02 | 36 |
GO:00706132 | Oral cavity | OSCC | regulation of protein processing | 35/7305 | 65/18723 | 1.07e-02 | 3.64e-02 | 35 |
GO:0045862110 | Oral cavity | LP | positive regulation of proteolysis | 165/4623 | 372/18723 | 5.40e-17 | 8.46e-15 | 165 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:001648513 | Oral cavity | LP | protein processing | 83/4623 | 225/18723 | 2.87e-05 | 4.52e-04 | 83 |
GO:190331711 | Oral cavity | LP | regulation of protein maturation | 29/4623 | 67/18723 | 6.51e-04 | 5.90e-03 | 29 |
GO:007061311 | Oral cavity | LP | regulation of protein processing | 28/4623 | 65/18723 | 8.77e-04 | 7.59e-03 | 28 |
GO:00316383 | Oral cavity | LP | zymogen activation | 26/4623 | 60/18723 | 1.19e-03 | 9.62e-03 | 26 |
GO:004586229 | Skin | cSCC | positive regulation of proteolysis | 169/4864 | 372/18723 | 2.43e-16 | 2.21e-14 | 169 |
GO:005160419 | Skin | cSCC | protein maturation | 117/4864 | 294/18723 | 1.27e-07 | 2.93e-06 | 117 |
GO:00164858 | Skin | cSCC | protein processing | 79/4864 | 225/18723 | 1.43e-03 | 9.02e-03 | 79 |
GO:0045862113 | Thyroid | PTC | positive regulation of proteolysis | 198/5968 | 372/18723 | 6.68e-18 | 6.91e-16 | 198 |
GO:005160420 | Thyroid | PTC | protein maturation | 132/5968 | 294/18723 | 1.71e-06 | 2.39e-05 | 132 |
GO:00164859 | Thyroid | PTC | protein processing | 95/5968 | 225/18723 | 6.60e-04 | 4.15e-03 | 95 |
GO:00107554 | Thyroid | PTC | regulation of plasminogen activation | 9/5968 | 13/18723 | 6.33e-03 | 2.79e-02 | 9 |
GO:004586234 | Thyroid | ATC | positive regulation of proteolysis | 202/6293 | 372/18723 | 1.07e-16 | 9.42e-15 | 202 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLG | SNV | Missense_Mutation | novel | c.871N>T | p.Val291Leu | p.V291L | P00747 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-3C-AAAU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | zoladex | SD |
PLG | SNV | Missense_Mutation | novel | c.1833N>C | p.Leu611Phe | p.L611F | P00747 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PLG | SNV | Missense_Mutation | novel | c.22C>A | p.Leu8Ile | p.L8I | P00747 | protein_coding | tolerated(0.05) | benign(0.368) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLG | SNV | Missense_Mutation | | c.1993N>C | p.Asp665His | p.D665H | P00747 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLG | SNV | Missense_Mutation | novel | c.1670N>C | p.Val557Ala | p.V557A | P00747 | protein_coding | deleterious(0) | benign(0.411) | TCGA-AR-A2LJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
PLG | SNV | Missense_Mutation | novel | c.866T>G | p.Val289Gly | p.V289G | P00747 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLG | SNV | Missense_Mutation | | c.747N>A | p.Asp249Glu | p.D249E | P00747 | protein_coding | tolerated(0.05) | benign(0.167) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLG | SNV | Missense_Mutation | novel | c.866T>G | p.Val289Gly | p.V289G | P00747 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PLG | SNV | Missense_Mutation | | c.1078G>A | p.Glu360Lys | p.E360K | P00747 | protein_coding | tolerated(0.1) | benign(0.345) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
PLG | SNV | Missense_Mutation | novel | c.288N>T | p.Lys96Asn | p.K96N | P00747 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-E2-A2P5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | UROKINASE | UROKINASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | ALTEPLASE | ALTEPLASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | ALTEPLASE | ALTEPLASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | DESMOTEPLASE | DESMOTEPLASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | Reteplase | RETEPLASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | NYSTATIN | NYSTATIN | 7721938 |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | ANISTREPLASE | ANISTREPLASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | RETEPLASE | RETEPLASE | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | BORTEZOMIB | BORTEZOMIB | 20875739 |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | | ANTIDEPRESSANTS | | 16890384 |