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Gene: MT1M |
Gene summary for MT1M |
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Gene information | Species | Human | Gene symbol | MT1M | Gene ID | 4499 |
Gene name | metallothionein 1M | |
Gene Alias | MT-1M | |
Cytomap | 16q13 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | A0A024R6T4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4499 | MT1M | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.94e-08 | 7.05e-01 | -0.1808 |
4499 | MT1M | HTA11_347_2000001011 | Human | Colorectum | AD | 7.48e-13 | 5.19e-01 | -0.1954 |
4499 | MT1M | HTA11_411_2000001011 | Human | Colorectum | SER | 2.83e-02 | 7.83e-01 | -0.2602 |
4499 | MT1M | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.19e-02 | 2.81e-01 | -0.1207 |
4499 | MT1M | HTA11_866_2000001011 | Human | Colorectum | AD | 3.99e-18 | 6.02e-01 | -0.1001 |
4499 | MT1M | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.06e-13 | 1.17e+00 | -0.1706 |
4499 | MT1M | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.10e-22 | 1.65e+00 | -0.2061 |
4499 | MT1M | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.87e-08 | 9.47e-01 | -0.1462 |
4499 | MT1M | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.28e-03 | 6.28e-01 | 0.0171 |
4499 | MT1M | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.62e-12 | 1.09e+00 | -0.0124 |
4499 | MT1M | LZE8T | Human | Esophagus | ESCC | 1.56e-04 | 2.46e-01 | 0.067 |
4499 | MT1M | P4T-E | Human | Esophagus | ESCC | 4.31e-07 | 9.77e-01 | 0.1323 |
4499 | MT1M | P8T-E | Human | Esophagus | ESCC | 7.09e-10 | 2.66e-01 | 0.0889 |
4499 | MT1M | P11T-E | Human | Esophagus | ESCC | 3.82e-02 | 1.23e+00 | 0.1426 |
4499 | MT1M | P12T-E | Human | Esophagus | ESCC | 2.89e-19 | 7.16e-01 | 0.1122 |
4499 | MT1M | P16T-E | Human | Esophagus | ESCC | 4.82e-25 | 6.31e-01 | 0.1153 |
4499 | MT1M | P20T-E | Human | Esophagus | ESCC | 7.63e-21 | 7.89e-01 | 0.1124 |
4499 | MT1M | P21T-E | Human | Esophagus | ESCC | 2.07e-66 | 1.84e+00 | 0.1617 |
4499 | MT1M | P24T-E | Human | Esophagus | ESCC | 9.58e-29 | 1.20e+00 | 0.1287 |
4499 | MT1M | P27T-E | Human | Esophagus | ESCC | 1.28e-11 | 2.49e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005507632 | Thyroid | ATC | transition metal ion homeostasis | 66/6293 | 138/18723 | 3.64e-04 | 2.25e-03 | 66 |
GO:007124124 | Thyroid | ATC | cellular response to inorganic substance | 98/6293 | 226/18723 | 1.35e-03 | 7.02e-03 | 98 |
GO:004668632 | Thyroid | ATC | response to cadmium ion | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:009875433 | Thyroid | ATC | detoxification | 66/6293 | 152/18723 | 7.23e-03 | 2.85e-02 | 66 |
GO:007124823 | Thyroid | ATC | cellular response to metal ion | 82/6293 | 197/18723 | 1.11e-02 | 3.99e-02 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MT1M | SNV | Missense_Mutation | c.4N>A | p.Asp2Asn | p.D2N | Q8N339 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.831) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
MT1M | insertion | Nonsense_Mutation | novel | c.83_84insAGACATTTGAGTCTTCAGGGTTCAGCACAGAAGGTT | p.Ser28_Cys29insAspIleTerValPheArgValGlnHisArgArgPhe | p.S28_C29insDI*VFRVQHRRF | Q8N339 | protein_coding | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MT1M | SNV | Missense_Mutation | rs568220625 | c.49N>A | p.Gly17Ser | p.G17S | Q8N339 | protein_coding | tolerated(0.37) | benign(0.009) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MT1M | SNV | Missense_Mutation | c.88N>G | p.Lys30Glu | p.K30E | Q8N339 | protein_coding | deleterious(0.01) | benign(0.225) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MT1M | SNV | Missense_Mutation | c.80N>A | p.Thr27Asn | p.T27N | Q8N339 | protein_coding | deleterious(0) | possibly_damaging(0.508) | TCGA-DC-4749-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MT1M | SNV | Missense_Mutation | novel | c.179N>A | p.Cys60Tyr | p.C60Y | Q8N339 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.998) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MT1M | SNV | Missense_Mutation | c.177C>G | p.Cys59Trp | p.C59W | Q8N339 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
MT1M | SNV | Missense_Mutation | novel | c.38G>A | p.Cys13Tyr | p.C13Y | Q8N339 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
MT1M | SNV | Missense_Mutation | c.85T>A | p.Cys29Ser | p.C29S | Q8N339 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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