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Gene: MED4 |
Gene summary for MED4 |
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Gene information | Species | Human | Gene symbol | MED4 | Gene ID | 29079 |
Gene name | mediator complex subunit 4 | |
Gene Alias | ARC36 | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NPJ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29079 | MED4 | LZE4T | Human | Esophagus | ESCC | 7.93e-13 | 1.35e-01 | 0.0811 |
29079 | MED4 | LZE7T | Human | Esophagus | ESCC | 3.21e-06 | 2.27e-01 | 0.0667 |
29079 | MED4 | LZE8T | Human | Esophagus | ESCC | 2.95e-06 | 6.39e-02 | 0.067 |
29079 | MED4 | LZE20T | Human | Esophagus | ESCC | 3.18e-06 | 6.75e-02 | 0.0662 |
29079 | MED4 | LZE22D1 | Human | Esophagus | HGIN | 5.79e-05 | 7.09e-02 | 0.0595 |
29079 | MED4 | LZE22T | Human | Esophagus | ESCC | 1.08e-04 | 1.92e-01 | 0.068 |
29079 | MED4 | LZE24T | Human | Esophagus | ESCC | 8.26e-16 | 1.84e-01 | 0.0596 |
29079 | MED4 | LZE6T | Human | Esophagus | ESCC | 8.30e-05 | -4.12e-02 | 0.0845 |
29079 | MED4 | P1T-E | Human | Esophagus | ESCC | 1.18e-08 | 2.77e-01 | 0.0875 |
29079 | MED4 | P2T-E | Human | Esophagus | ESCC | 6.15e-20 | 4.66e-01 | 0.1177 |
29079 | MED4 | P4T-E | Human | Esophagus | ESCC | 6.84e-22 | 1.15e-01 | 0.1323 |
29079 | MED4 | P5T-E | Human | Esophagus | ESCC | 3.48e-09 | 1.02e-01 | 0.1327 |
29079 | MED4 | P8T-E | Human | Esophagus | ESCC | 8.58e-43 | 6.68e-01 | 0.0889 |
29079 | MED4 | P9T-E | Human | Esophagus | ESCC | 3.17e-17 | 3.14e-01 | 0.1131 |
29079 | MED4 | P10T-E | Human | Esophagus | ESCC | 6.93e-20 | 4.36e-01 | 0.116 |
29079 | MED4 | P11T-E | Human | Esophagus | ESCC | 8.81e-15 | 2.39e-01 | 0.1426 |
29079 | MED4 | P12T-E | Human | Esophagus | ESCC | 3.31e-23 | 4.38e-01 | 0.1122 |
29079 | MED4 | P15T-E | Human | Esophagus | ESCC | 5.61e-24 | 4.60e-01 | 0.1149 |
29079 | MED4 | P16T-E | Human | Esophagus | ESCC | 7.02e-24 | 5.31e-01 | 0.1153 |
29079 | MED4 | P17T-E | Human | Esophagus | ESCC | 9.56e-04 | 3.92e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063675 | Thyroid | PTC | transcription initiation from RNA polymerase II promoter | 44/5968 | 77/18723 | 4.04e-06 | 5.05e-05 | 44 |
GO:00063525 | Thyroid | PTC | DNA-templated transcription, initiation | 63/5968 | 130/18723 | 5.72e-05 | 5.05e-04 | 63 |
GO:20001426 | Thyroid | PTC | regulation of DNA-templated transcription, initiation | 21/5968 | 40/18723 | 5.37e-03 | 2.47e-02 | 21 |
GO:00602604 | Thyroid | PTC | regulation of transcription initiation from RNA polymerase II promoter | 18/5968 | 33/18723 | 5.77e-03 | 2.60e-02 | 18 |
GO:0048193111 | Thyroid | ATC | Golgi vesicle transport | 189/6293 | 296/18723 | 9.58e-27 | 5.05e-24 | 189 |
GO:000688823 | Thyroid | ATC | endoplasmic reticulum to Golgi vesicle-mediated transport | 84/6293 | 130/18723 | 4.40e-13 | 1.97e-11 | 84 |
GO:0043123111 | Thyroid | ATC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 97/6293 | 186/18723 | 1.31e-07 | 2.16e-06 | 97 |
GO:0043122112 | Thyroid | ATC | regulation of I-kappaB kinase/NF-kappaB signaling | 123/6293 | 249/18723 | 1.65e-07 | 2.64e-06 | 123 |
GO:0007249111 | Thyroid | ATC | I-kappaB kinase/NF-kappaB signaling | 135/6293 | 281/18723 | 3.31e-07 | 4.91e-06 | 135 |
GO:000703015 | Thyroid | ATC | Golgi organization | 79/6293 | 157/18723 | 1.07e-05 | 1.05e-04 | 79 |
GO:000636712 | Thyroid | ATC | transcription initiation from RNA polymerase II promoter | 44/6293 | 77/18723 | 1.86e-05 | 1.70e-04 | 44 |
GO:000635213 | Thyroid | ATC | DNA-templated transcription, initiation | 64/6293 | 130/18723 | 1.60e-04 | 1.10e-03 | 64 |
GO:200014213 | Thyroid | ATC | regulation of DNA-templated transcription, initiation | 22/6293 | 40/18723 | 4.32e-03 | 1.80e-02 | 22 |
GO:006026012 | Thyroid | ATC | regulation of transcription initiation from RNA polymerase II promoter | 18/6293 | 33/18723 | 1.06e-02 | 3.84e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa04919113 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491926 | Oral cavity | OSCC | Thyroid hormone signaling pathway | 73/3704 | 121/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 73 |
hsa04919112 | Oral cavity | OSCC | Thyroid hormone signaling pathway | 73/3704 | 121/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED4 | SNV | Missense_Mutation | rs775421698 | c.533N>T | p.Thr178Ile | p.T178I | Q9NPJ6 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MED4 | SNV | Missense_Mutation | c.479N>A | p.Ala160Asp | p.A160D | Q9NPJ6 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MED4 | SNV | Missense_Mutation | c.193G>A | p.Val65Ile | p.V65I | Q9NPJ6 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MED4 | SNV | Missense_Mutation | c.373N>A | p.Val125Ile | p.V125I | Q9NPJ6 | protein_coding | tolerated(1) | benign(0.045) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MED4 | SNV | Missense_Mutation | rs144201204 | c.592N>A | p.Val198Met | p.V198M | Q9NPJ6 | protein_coding | tolerated(0.22) | benign(0.326) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MED4 | SNV | Missense_Mutation | c.229C>G | p.Gln77Glu | p.Q77E | Q9NPJ6 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-A5-A0GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MED4 | SNV | Missense_Mutation | novel | c.768N>T | p.Glu256Asp | p.E256D | Q9NPJ6 | protein_coding | tolerated(0.06) | probably_damaging(0.931) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MED4 | SNV | Missense_Mutation | novel | c.151N>C | p.Ser51Pro | p.S51P | Q9NPJ6 | protein_coding | tolerated(0.47) | benign(0.328) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MED4 | SNV | Missense_Mutation | rs199856249 | c.215N>A | p.Arg72Gln | p.R72Q | Q9NPJ6 | protein_coding | deleterious(0.01) | benign(0.147) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MED4 | SNV | Missense_Mutation | c.506N>A | p.Pro169Gln | p.P169Q | Q9NPJ6 | protein_coding | tolerated(0.53) | probably_damaging(0.999) | TCGA-55-6971-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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