GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332135 | Thyroid | ATC | negative regulation of protein modification by small protein conjugation or removal | 60/6293 | 95/18723 | 3.53e-09 | 8.14e-08 | 60 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:005143834 | Thyroid | ATC | regulation of ubiquitin-protein transferase activity | 38/6293 | 53/18723 | 1.60e-08 | 3.23e-07 | 38 |
GO:001072022 | Thyroid | ATC | positive regulation of cell development | 146/6293 | 298/18723 | 2.36e-08 | 4.56e-07 | 146 |
GO:0051017210 | Thyroid | ATC | actin filament bundle assembly | 85/6293 | 157/18723 | 8.99e-08 | 1.54e-06 | 85 |
GO:0061572210 | Thyroid | ATC | actin filament bundle organization | 86/6293 | 161/18723 | 1.68e-07 | 2.69e-06 | 86 |
GO:004867522 | Thyroid | ATC | axon extension | 68/6293 | 120/18723 | 1.73e-07 | 2.75e-06 | 68 |
GO:005076922 | Thyroid | ATC | positive regulation of neurogenesis | 112/6293 | 225/18723 | 3.53e-07 | 5.21e-06 | 112 |
GO:005076723 | Thyroid | ATC | regulation of neurogenesis | 168/6293 | 364/18723 | 3.73e-07 | 5.48e-06 | 168 |
GO:004577314 | Thyroid | ATC | positive regulation of axon extension | 30/6293 | 42/18723 | 6.06e-07 | 8.44e-06 | 30 |
GO:199013824 | Thyroid | ATC | neuron projection extension | 89/6293 | 172/18723 | 6.63e-07 | 9.13e-06 | 89 |
GO:005077213 | Thyroid | ATC | positive regulation of axonogenesis | 48/6293 | 79/18723 | 6.89e-07 | 9.35e-06 | 48 |
GO:005144434 | Thyroid | ATC | negative regulation of ubiquitin-protein transferase activity | 17/6293 | 19/18723 | 7.02e-07 | 9.42e-06 | 17 |
GO:004858823 | Thyroid | ATC | developmental cell growth | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:006056019 | Thyroid | ATC | developmental growth involved in morphogenesis | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:003103226 | Thyroid | ATC | actomyosin structure organization | 98/6293 | 196/18723 | 1.44e-06 | 1.77e-05 | 98 |
GO:000726619 | Thyroid | ATC | Rho protein signal transduction | 73/6293 | 137/18723 | 1.58e-06 | 1.93e-05 | 73 |
GO:005077011 | Thyroid | ATC | regulation of axonogenesis | 80/6293 | 154/18723 | 1.95e-06 | 2.34e-05 | 80 |
GO:005196014 | Thyroid | ATC | regulation of nervous system development | 195/6293 | 443/18723 | 2.62e-06 | 3.06e-05 | 195 |
GO:005196221 | Thyroid | ATC | positive regulation of nervous system development | 126/6293 | 272/18723 | 8.17e-06 | 8.27e-05 | 126 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIMK1 | SNV | Missense_Mutation | | c.1567N>A | p.Gly523Ser | p.G523S | P53667 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | novel | c.139N>T | p.Ala47Ser | p.A47S | P53667 | protein_coding | tolerated(0.87) | benign(0.007) | TCGA-PE-A5DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | CR |
LIMK1 | insertion | Frame_Shift_Ins | novel | c.544_545insACCAGGAAGCTTCACTGAGCTTCAGCAGCCAGAGTTT | p.Ile182AsnfsTer14 | p.I182Nfs*14 | P53667 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | insertion | Frame_Shift_Ins | novel | c.1712_1713insC | p.Asn574LysfsTer71 | p.N574Kfs*71 | P53667 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | | c.358G>A | p.Asp120Asn | p.D120N | P53667 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
LIMK1 | SNV | Missense_Mutation | | c.1557N>C | p.Glu519Asp | p.E519D | P53667 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LIMK1 | SNV | Missense_Mutation | | c.646N>A | p.Ser216Thr | p.S216T | P53667 | protein_coding | tolerated(0.11) | benign(0.117) | TCGA-EA-A556-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | rs782256257 | c.985C>T | p.Arg329Trp | p.R329W | P53667 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-IR-A3LC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | Complete Response |
LIMK1 | SNV | Missense_Mutation | novel | c.1563N>G | p.Ile521Met | p.I521M | P53667 | protein_coding | tolerated(0.71) | benign(0.323) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
LIMK1 | SNV | Missense_Mutation | novel | c.1864N>C | p.Glu622Gln | p.E622Q | P53667 | protein_coding | deleterious(0.04) | possibly_damaging(0.65) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | PAZOPANIB | PAZOPANIB | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | GO-6976 | GO-6976 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | CENISERTIB | CENISERTIB | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | TAE-684 | TAE-684 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | BMS-345541 | BMS-345541 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | TCMDC-125758 | CHEMBL546797 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565797 | | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | SB-220025 | SB-220025 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | RG-1530 | RG-1530 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 363894217 | VORUCICLIB | |