![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LGALS7 |
Gene summary for LGALS7 |
![]() |
Gene information | Species | Human | Gene symbol | LGALS7 | Gene ID | 3963 |
Gene name | galectin 7 | |
Gene Alias | GAL7 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P47929 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3963 | LGALS7 | CA_HPV_1 | Human | Cervix | CC | 1.91e-09 | -2.73e-01 | 0.0264 |
3963 | LGALS7 | CA_HPV_3 | Human | Cervix | CC | 4.16e-05 | -2.47e-01 | 0.0414 |
3963 | LGALS7 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 7.11e-03 | -1.53e-01 | 0.0116 |
3963 | LGALS7 | CCII_1 | Human | Cervix | CC | 8.34e-03 | -2.73e-01 | 0.3249 |
3963 | LGALS7 | Tumor | Human | Cervix | CC | 5.89e-19 | 5.98e-01 | 0.1241 |
3963 | LGALS7 | sample3 | Human | Cervix | CC | 2.85e-11 | 3.77e-01 | 0.1387 |
3963 | LGALS7 | H2 | Human | Cervix | HSIL_HPV | 5.96e-05 | -2.32e-01 | 0.0632 |
3963 | LGALS7 | L1 | Human | Cervix | CC | 1.39e-23 | 9.87e-01 | 0.0802 |
3963 | LGALS7 | T3 | Human | Cervix | CC | 6.20e-12 | 3.96e-01 | 0.1389 |
3963 | LGALS7 | LZE4T | Human | Esophagus | ESCC | 7.27e-04 | -2.24e-01 | 0.0811 |
3963 | LGALS7 | LZE20T | Human | Esophagus | ESCC | 2.38e-09 | 1.52e+00 | 0.0662 |
3963 | LGALS7 | LZE22T | Human | Esophagus | ESCC | 1.49e-06 | 1.24e+00 | 0.068 |
3963 | LGALS7 | LZE24T | Human | Esophagus | ESCC | 5.89e-06 | 8.08e-01 | 0.0596 |
3963 | LGALS7 | LZE21T | Human | Esophagus | ESCC | 3.28e-09 | 3.29e+00 | 0.0655 |
3963 | LGALS7 | P1T-E | Human | Esophagus | ESCC | 1.78e-07 | 1.40e+00 | 0.0875 |
3963 | LGALS7 | P4T-E | Human | Esophagus | ESCC | 1.62e-19 | 1.19e+00 | 0.1323 |
3963 | LGALS7 | P5T-E | Human | Esophagus | ESCC | 2.95e-50 | 1.83e+00 | 0.1327 |
3963 | LGALS7 | P9T-E | Human | Esophagus | ESCC | 1.42e-42 | 2.34e+00 | 0.1131 |
3963 | LGALS7 | P10T-E | Human | Esophagus | ESCC | 4.57e-13 | 9.55e-01 | 0.116 |
3963 | LGALS7 | P11T-E | Human | Esophagus | ESCC | 1.56e-07 | 3.12e+00 | 0.1426 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004664021 | Oral cavity | NEOLP | regulation of alpha-beta T cell proliferation | 10/2005 | 35/18723 | 2.88e-03 | 1.77e-02 | 10 |
GO:004665122 | Oral cavity | NEOLP | lymphocyte proliferation | 46/2005 | 288/18723 | 3.72e-03 | 2.15e-02 | 46 |
GO:003294312 | Oral cavity | NEOLP | mononuclear cell proliferation | 46/2005 | 291/18723 | 4.54e-03 | 2.54e-02 | 46 |
GO:002240822 | Oral cavity | NEOLP | negative regulation of cell-cell adhesion | 33/2005 | 196/18723 | 5.76e-03 | 3.04e-02 | 33 |
GO:005067013 | Oral cavity | NEOLP | regulation of lymphocyte proliferation | 36/2005 | 225/18723 | 9.20e-03 | 4.38e-02 | 36 |
GO:003294413 | Oral cavity | NEOLP | regulation of mononuclear cell proliferation | 36/2005 | 227/18723 | 1.05e-02 | 4.89e-02 | 36 |
GO:004211019 | Skin | AK | T cell activation | 85/1910 | 487/18723 | 5.16e-07 | 1.85e-05 | 85 |
GO:002240725 | Skin | AK | regulation of cell-cell adhesion | 79/1910 | 448/18723 | 8.55e-07 | 2.81e-05 | 79 |
GO:005086317 | Skin | AK | regulation of T cell activation | 59/1910 | 329/18723 | 1.20e-05 | 2.46e-04 | 59 |
GO:000716210 | Skin | AK | negative regulation of cell adhesion | 55/1910 | 303/18723 | 1.64e-05 | 3.15e-04 | 55 |
GO:000715919 | Skin | AK | leukocyte cell-cell adhesion | 64/1910 | 371/18723 | 1.87e-05 | 3.52e-04 | 64 |
GO:190303718 | Skin | AK | regulation of leukocyte cell-cell adhesion | 57/1910 | 336/18723 | 8.41e-05 | 1.15e-03 | 57 |
GO:000268317 | Skin | AK | negative regulation of immune system process | 67/1910 | 434/18723 | 3.74e-04 | 3.63e-03 | 67 |
GO:00224087 | Skin | AK | negative regulation of cell-cell adhesion | 32/1910 | 196/18723 | 5.06e-03 | 2.84e-02 | 32 |
GO:0022407110 | Skin | SCCIS | regulation of cell-cell adhesion | 53/919 | 448/18723 | 2.75e-09 | 1.45e-06 | 53 |
GO:0042110110 | Skin | SCCIS | T cell activation | 53/919 | 487/18723 | 4.77e-08 | 8.19e-06 | 53 |
GO:000268318 | Skin | SCCIS | negative regulation of immune system process | 49/919 | 434/18723 | 4.92e-08 | 8.19e-06 | 49 |
GO:0007159110 | Skin | SCCIS | leukocyte cell-cell adhesion | 44/919 | 371/18723 | 5.77e-08 | 9.01e-06 | 44 |
GO:190303719 | Skin | SCCIS | regulation of leukocyte cell-cell adhesion | 40/919 | 336/18723 | 2.09e-07 | 2.17e-05 | 40 |
GO:005086318 | Skin | SCCIS | regulation of T cell activation | 39/919 | 329/18723 | 3.30e-07 | 3.03e-05 | 39 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS7 | SNV | Missense_Mutation | novel | c.215N>A | p.Arg72His | p.R72H | P47929 | protein_coding | tolerated(0.16) | benign(0.009) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
LGALS7 | SNV | Missense_Mutation | novel | c.96N>C | p.Arg32Ser | p.R32S | P47929 | protein_coding | tolerated(0.05) | possibly_damaging(0.476) | TCGA-DD-A1EL-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LGALS7 | SNV | Missense_Mutation | novel | c.235N>T | p.Val79Phe | p.V79F | P47929 | protein_coding | tolerated(0.17) | benign(0.158) | TCGA-K7-A6G5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |