Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KIF20B_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIF20B_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KIF20B_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/KIF20B_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KIF20B_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003001025 | Skin | cSCC | establishment of cell polarity | 65/4864 | 143/18723 | 3.60e-07 | 7.18e-06 | 65 |
GO:004578717 | Skin | cSCC | positive regulation of cell cycle | 120/4864 | 313/18723 | 8.95e-07 | 1.64e-05 | 120 |
GO:009006815 | Skin | cSCC | positive regulation of cell cycle process | 92/4864 | 236/18723 | 7.33e-06 | 1.01e-04 | 92 |
GO:001402015 | Skin | cSCC | primary neural tube formation | 39/4864 | 94/18723 | 7.37e-04 | 5.15e-03 | 39 |
GO:000184315 | Skin | cSCC | neural tube closure | 37/4864 | 88/18723 | 7.39e-04 | 5.15e-03 | 37 |
GO:006060615 | Skin | cSCC | tube closure | 37/4864 | 89/18723 | 9.52e-04 | 6.47e-03 | 37 |
GO:000184117 | Skin | cSCC | neural tube formation | 41/4864 | 102/18723 | 1.16e-03 | 7.61e-03 | 41 |
GO:000183822 | Skin | cSCC | embryonic epithelial tube formation | 47/4864 | 121/18723 | 1.26e-03 | 8.18e-03 | 47 |
GO:00443805 | Skin | cSCC | protein localization to cytoskeleton | 26/4864 | 58/18723 | 1.44e-03 | 9.09e-03 | 26 |
GO:001633113 | Skin | cSCC | morphogenesis of embryonic epithelium | 55/4864 | 147/18723 | 1.45e-03 | 9.11e-03 | 55 |
GO:00324654 | Skin | cSCC | regulation of cytokinesis | 37/4864 | 92/18723 | 1.94e-03 | 1.17e-02 | 37 |
GO:00726986 | Skin | cSCC | protein localization to microtubule cytoskeleton | 24/4864 | 54/18723 | 2.49e-03 | 1.42e-02 | 24 |
GO:003514822 | Skin | cSCC | tube formation | 54/4864 | 148/18723 | 3.00e-03 | 1.66e-02 | 54 |
GO:007217521 | Skin | cSCC | epithelial tube formation | 49/4864 | 132/18723 | 3.06e-03 | 1.68e-02 | 49 |
GO:00513026 | Skin | cSCC | regulation of cell division | 61/4864 | 177/18723 | 7.34e-03 | 3.47e-02 | 61 |
GO:0032386111 | Thyroid | PTC | regulation of intracellular transport | 202/5968 | 337/18723 | 1.12e-26 | 3.93e-24 | 202 |
GO:0033157112 | Thyroid | PTC | regulation of intracellular protein transport | 149/5968 | 229/18723 | 3.83e-25 | 1.15e-22 | 149 |
GO:0032388112 | Thyroid | PTC | positive regulation of intracellular transport | 132/5968 | 202/18723 | 1.10e-22 | 2.57e-20 | 132 |
GO:0090316110 | Thyroid | PTC | positive regulation of intracellular protein transport | 109/5968 | 160/18723 | 4.20e-21 | 7.79e-19 | 109 |
GO:1904951113 | Thyroid | PTC | positive regulation of establishment of protein localization | 175/5968 | 319/18723 | 1.10e-17 | 1.12e-15 | 175 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF20B | SNV | Missense_Mutation | | c.2560N>T | p.Ser854Cys | p.S854C | Q96Q89 | protein_coding | tolerated(0.12) | possibly_damaging(0.887) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIF20B | SNV | Missense_Mutation | | c.5099T>A | p.Ile1700Lys | p.I1700K | Q96Q89 | protein_coding | tolerated(0.05) | benign(0.01) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIF20B | SNV | Missense_Mutation | | c.3128N>A | p.Arg1043Gln | p.R1043Q | Q96Q89 | protein_coding | tolerated(0.61) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF20B | SNV | Missense_Mutation | novel | c.3230N>C | p.Gln1077Pro | p.Q1077P | Q96Q89 | protein_coding | deleterious(0.01) | benign(0.278) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF20B | SNV | Missense_Mutation | novel | c.2411C>G | p.Ser804Cys | p.S804C | Q96Q89 | protein_coding | deleterious(0.02) | benign(0.439) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF20B | SNV | Missense_Mutation | novel | c.825N>G | p.Phe275Leu | p.F275L | Q96Q89 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-E9-A3X8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphane | CR |
KIF20B | SNV | Missense_Mutation | novel | c.1783N>A | p.Leu595Ile | p.L595I | Q96Q89 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-Z7-A8R5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
KIF20B | insertion | Nonsense_Mutation | novel | c.1385_1386insATTTTAGG | p.Tyr463PhefsTer2 | p.Y463Ffs*2 | Q96Q89 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KIF20B | insertion | Nonsense_Mutation | novel | c.1387_1388insGAGTAAATATAAATCAGCCTTC | p.Tyr463Ter | p.Y463* | Q96Q89 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KIF20B | insertion | Nonsense_Mutation | novel | c.4957_4958insGAGGAGGCTGAGAT | p.Ala1653GlyfsTer4 | p.A1653Gfs*4 | Q96Q89 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |