Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/HRAS_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HRAS_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HRAS_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HRAS_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HRAS_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HRAS_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00508522 | Breast | DCIS | T cell receptor signaling pathway | 20/1390 | 123/18723 | 7.14e-04 | 8.56e-03 | 20 |
GO:190303622 | Breast | DCIS | positive regulation of response to wounding | 14/1390 | 72/18723 | 7.32e-04 | 8.69e-03 | 14 |
GO:190121521 | Breast | DCIS | negative regulation of neuron death | 29/1390 | 208/18723 | 7.58e-04 | 8.95e-03 | 29 |
GO:190547722 | Breast | DCIS | positive regulation of protein localization to membrane | 18/1390 | 106/18723 | 7.67e-04 | 8.97e-03 | 18 |
GO:007037111 | Breast | DCIS | ERK1 and ERK2 cascade | 41/1390 | 330/18723 | 8.11e-04 | 9.32e-03 | 41 |
GO:190303422 | Breast | DCIS | regulation of response to wounding | 24/1390 | 167/18723 | 1.37e-03 | 1.42e-02 | 24 |
GO:00457402 | Breast | DCIS | positive regulation of DNA replication | 9/1390 | 40/18723 | 2.23e-03 | 2.04e-02 | 9 |
GO:000225311 | Breast | DCIS | activation of immune response | 43/1390 | 375/18723 | 2.96e-03 | 2.54e-02 | 43 |
GO:005067921 | Breast | DCIS | positive regulation of epithelial cell proliferation | 27/1390 | 207/18723 | 3.00e-03 | 2.56e-02 | 27 |
GO:003315713 | Breast | DCIS | regulation of intracellular protein transport | 29/1390 | 229/18723 | 3.34e-03 | 2.81e-02 | 29 |
GO:009030322 | Breast | DCIS | positive regulation of wound healing | 11/1390 | 59/18723 | 3.71e-03 | 3.00e-02 | 11 |
GO:000756921 | Breast | DCIS | cell aging | 19/1390 | 132/18723 | 4.03e-03 | 3.20e-02 | 19 |
GO:003238813 | Breast | DCIS | positive regulation of intracellular transport | 26/1390 | 202/18723 | 4.24e-03 | 3.33e-02 | 26 |
GO:00971785 | Breast | DCIS | ruffle assembly | 9/1390 | 44/18723 | 4.42e-03 | 3.41e-02 | 9 |
GO:190437522 | Breast | DCIS | regulation of protein localization to cell periphery | 18/1390 | 125/18723 | 5.02e-03 | 3.73e-02 | 18 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0516718 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0491518 | Breast | Precancer | Estrogen signaling pathway | 28/684 | 138/8465 | 4.10e-06 | 5.39e-05 | 4.13e-05 | 28 |
hsa0541718 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa042108 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0516618 | Breast | Precancer | Human T-cell leukemia virus 1 infection | 33/684 | 222/8465 | 4.29e-04 | 3.31e-03 | 2.53e-03 | 33 |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0520514 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0516316 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa052309 | Breast | Precancer | Central carbon metabolism in cancer | 13/684 | 70/8465 | 3.57e-03 | 2.17e-02 | 1.66e-02 | 13 |
hsa052196 | Breast | Precancer | Bladder cancer | 9/684 | 41/8465 | 4.65e-03 | 2.72e-02 | 2.08e-02 | 9 |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | Pz-1 | | 26126987 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | MEK INHIBITOR PD0325901 | | 26544513 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | Sirolimus | SIROLIMUS | 26882569 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | Selumetinib | SELUMETINIB | 26544513,27222538 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | BRYOSTATIN-1 | | 16483930 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | rigosertib | RIGOSERTIB | 27104980 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | VIRAL VECTOR | | 10911621 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | REOLYSIN | PELAREOREP | |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | Everolimus | EVEROLIMUS | 26544513 |
3265 | HRAS | CLINICALLY ACTIONABLE, DRUG RESISTANCE, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME | | LAK | | 3489774 |