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Gene: GSTA1 |
Gene summary for GSTA1 |
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Gene information | Species | Human | Gene symbol | GSTA1 | Gene ID | 2938 |
Gene name | glutathione S-transferase alpha 1 | |
Gene Alias | GST-epsilon | |
Cytomap | 6p12.2 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | A0A140VJK4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2938 | GSTA1 | LZE2D | Human | Esophagus | HGIN | 3.07e-05 | 2.83e+00 | 0.0642 |
2938 | GSTA1 | LZE2T | Human | Esophagus | ESCC | 1.58e-09 | 3.09e+00 | 0.082 |
2938 | GSTA1 | LZE20T | Human | Esophagus | ESCC | 5.56e-09 | 1.69e+00 | 0.0662 |
2938 | GSTA1 | LZE22D1 | Human | Esophagus | HGIN | 7.96e-03 | 1.26e+00 | 0.0595 |
2938 | GSTA1 | LZE24T | Human | Esophagus | ESCC | 2.75e-56 | 4.31e+00 | 0.0596 |
2938 | GSTA1 | LZE22D3 | Human | Esophagus | HGIN | 2.39e-03 | 4.07e-01 | 0.0653 |
2938 | GSTA1 | LZE21T | Human | Esophagus | ESCC | 2.20e-05 | 1.76e+00 | 0.0655 |
2938 | GSTA1 | P2T-E | Human | Esophagus | ESCC | 2.21e-07 | -1.58e-01 | 0.1177 |
2938 | GSTA1 | P4T-E | Human | Esophagus | ESCC | 1.56e-13 | 1.49e+00 | 0.1323 |
2938 | GSTA1 | P5T-E | Human | Esophagus | ESCC | 2.29e-02 | -1.71e-01 | 0.1327 |
2938 | GSTA1 | P12T-E | Human | Esophagus | ESCC | 2.30e-15 | 2.14e+00 | 0.1122 |
2938 | GSTA1 | P15T-E | Human | Esophagus | ESCC | 2.52e-04 | 1.17e+00 | 0.1149 |
2938 | GSTA1 | P22T-E | Human | Esophagus | ESCC | 2.05e-03 | 5.18e-01 | 0.1236 |
2938 | GSTA1 | P26T-E | Human | Esophagus | ESCC | 1.19e-10 | 1.32e+00 | 0.1276 |
2938 | GSTA1 | P27T-E | Human | Esophagus | ESCC | 6.08e-03 | 9.93e-01 | 0.1055 |
2938 | GSTA1 | P30T-E | Human | Esophagus | ESCC | 8.97e-34 | 4.16e+00 | 0.137 |
2938 | GSTA1 | P32T-E | Human | Esophagus | ESCC | 1.66e-02 | -1.78e-01 | 0.1666 |
2938 | GSTA1 | P39T-E | Human | Esophagus | ESCC | 3.19e-10 | 6.70e-01 | 0.0894 |
2938 | GSTA1 | P61T-E | Human | Esophagus | ESCC | 3.28e-02 | -1.41e-01 | 0.099 |
2938 | GSTA1 | P62T-E | Human | Esophagus | ESCC | 3.21e-10 | 1.23e+00 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00972374 | Stomach | WIM | cellular response to toxic substance | 16/426 | 124/18723 | 2.24e-08 | 2.78e-06 | 16 |
GO:19907484 | Stomach | WIM | cellular detoxification | 15/426 | 116/18723 | 6.00e-08 | 6.26e-06 | 15 |
GO:00987544 | Stomach | WIM | detoxification | 17/426 | 152/18723 | 7.04e-08 | 7.15e-06 | 17 |
GO:00335594 | Stomach | WIM | unsaturated fatty acid metabolic process | 14/426 | 116/18723 | 3.95e-07 | 3.13e-05 | 14 |
GO:00988694 | Stomach | WIM | cellular oxidant detoxification | 13/426 | 101/18723 | 4.85e-07 | 3.77e-05 | 13 |
GO:00066924 | Stomach | WIM | prostanoid metabolic process | 9/426 | 49/18723 | 1.38e-06 | 9.26e-05 | 9 |
GO:00066934 | Stomach | WIM | prostaglandin metabolic process | 9/426 | 49/18723 | 1.38e-06 | 9.26e-05 | 9 |
GO:00096364 | Stomach | WIM | response to toxic substance | 20/426 | 262/18723 | 2.58e-06 | 1.65e-04 | 20 |
GO:00066904 | Stomach | WIM | icosanoid metabolic process | 13/426 | 123/18723 | 4.64e-06 | 2.45e-04 | 13 |
GO:01202543 | Stomach | WIM | olefinic compound metabolic process | 12/426 | 153/18723 | 2.03e-04 | 4.67e-03 | 12 |
GO:000663131 | Stomach | WIM | fatty acid metabolic process | 20/426 | 390/18723 | 6.59e-04 | 1.07e-02 | 20 |
GO:00987545 | Stomach | SIM | detoxification | 27/708 | 152/18723 | 1.79e-11 | 5.62e-09 | 27 |
GO:00972375 | Stomach | SIM | cellular response to toxic substance | 23/708 | 124/18723 | 2.29e-10 | 5.41e-08 | 23 |
GO:00096365 | Stomach | SIM | response to toxic substance | 34/708 | 262/18723 | 3.51e-10 | 6.55e-08 | 34 |
GO:19907485 | Stomach | SIM | cellular detoxification | 22/708 | 116/18723 | 3.61e-10 | 6.55e-08 | 22 |
GO:00094105 | Stomach | SIM | response to xenobiotic stimulus | 43/708 | 462/18723 | 5.43e-08 | 5.57e-06 | 43 |
GO:00335595 | Stomach | SIM | unsaturated fatty acid metabolic process | 19/708 | 116/18723 | 6.90e-08 | 6.65e-06 | 19 |
GO:000663141 | Stomach | SIM | fatty acid metabolic process | 38/708 | 390/18723 | 1.01e-07 | 8.64e-06 | 38 |
GO:00988695 | Stomach | SIM | cellular oxidant detoxification | 17/708 | 101/18723 | 2.24e-07 | 1.65e-05 | 17 |
GO:00066905 | Stomach | SIM | icosanoid metabolic process | 18/708 | 123/18723 | 8.59e-07 | 5.07e-05 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520839 | Esophagus | HGIN | Chemical carcinogenesis - reactive oxygen species | 92/1383 | 223/8465 | 2.41e-19 | 9.83e-18 | 7.80e-18 | 92 |
hsa0541839 | Esophagus | HGIN | Fluid shear stress and atherosclerosis | 42/1383 | 139/8465 | 2.92e-05 | 3.81e-04 | 3.02e-04 | 42 |
hsa05208115 | Esophagus | HGIN | Chemical carcinogenesis - reactive oxygen species | 92/1383 | 223/8465 | 2.41e-19 | 9.83e-18 | 7.80e-18 | 92 |
hsa05418115 | Esophagus | HGIN | Fluid shear stress and atherosclerosis | 42/1383 | 139/8465 | 2.92e-05 | 3.81e-04 | 3.02e-04 | 42 |
hsa05208211 | Esophagus | ESCC | Chemical carcinogenesis - reactive oxygen species | 168/4205 | 223/8465 | 1.83e-15 | 6.81e-14 | 3.49e-14 | 168 |
hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa015247 | Esophagus | ESCC | Platinum drug resistance | 56/4205 | 73/8465 | 1.85e-06 | 1.13e-05 | 5.78e-06 | 56 |
hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa05208310 | Esophagus | ESCC | Chemical carcinogenesis - reactive oxygen species | 168/4205 | 223/8465 | 1.83e-15 | 6.81e-14 | 3.49e-14 | 168 |
hsa05418310 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0152414 | Esophagus | ESCC | Platinum drug resistance | 56/4205 | 73/8465 | 1.85e-06 | 1.13e-05 | 5.78e-06 | 56 |
hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa0520814 | Liver | NAFLD | Chemical carcinogenesis - reactive oxygen species | 44/1043 | 223/8465 | 9.22e-04 | 1.31e-02 | 1.06e-02 | 44 |
hsa0541814 | Liver | NAFLD | Fluid shear stress and atherosclerosis | 30/1043 | 139/8465 | 1.37e-03 | 1.71e-02 | 1.38e-02 | 30 |
hsa0520815 | Liver | NAFLD | Chemical carcinogenesis - reactive oxygen species | 44/1043 | 223/8465 | 9.22e-04 | 1.31e-02 | 1.06e-02 | 44 |
hsa0541815 | Liver | NAFLD | Fluid shear stress and atherosclerosis | 30/1043 | 139/8465 | 1.37e-03 | 1.71e-02 | 1.38e-02 | 30 |
hsa0520822 | Liver | Cirrhotic | Chemical carcinogenesis - reactive oxygen species | 121/2530 | 223/8465 | 1.35e-14 | 4.08e-13 | 2.52e-13 | 121 |
hsa0541822 | Liver | Cirrhotic | Fluid shear stress and atherosclerosis | 62/2530 | 139/8465 | 1.53e-04 | 1.06e-03 | 6.54e-04 | 62 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSTA1 | SNV | Missense_Mutation | c.227C>T | p.Ala76Val | p.A76V | P08263 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
GSTA1 | SNV | Missense_Mutation | c.30C>G | p.Phe10Leu | p.F10L | P08263 | protein_coding | tolerated(0.09) | benign(0.023) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
GSTA1 | SNV | Missense_Mutation | rs755670661 | c.150N>C | p.Leu50Phe | p.L50F | P08263 | protein_coding | deleterious(0.04) | possibly_damaging(0.545) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
GSTA1 | SNV | Missense_Mutation | c.325C>G | p.Leu109Val | p.L109V | P08263 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GSTA1 | SNV | Missense_Mutation | c.630N>T | p.Glu210Asp | p.E210D | P08263 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
GSTA1 | SNV | Missense_Mutation | c.593N>C | p.Leu198Pro | p.L198P | P08263 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GSTA1 | SNV | Missense_Mutation | novel | c.451N>G | p.Asn151Asp | p.N151D | P08263 | protein_coding | tolerated(0.08) | benign(0.358) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GSTA1 | SNV | Missense_Mutation | c.347A>G | p.Glu116Gly | p.E116G | P08263 | protein_coding | deleterious(0.03) | benign(0.055) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GSTA1 | SNV | Missense_Mutation | c.643G>A | p.Glu215Lys | p.E215K | P08263 | protein_coding | tolerated(0.58) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GSTA1 | SNV | Missense_Mutation | rs776912908 | c.391N>T | p.Arg131Cys | p.R131C | P08263 | protein_coding | deleterious(0.03) | benign(0.32) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | vincristine | VINCRISTINE | 29938344,19448608 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | rituximab | RITUXIMAB | 29938344,19448608 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | PHYTOCHEMICALS | 15672752 | ||
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | BROMOSULFOPHTHALEIN | SULFOBROMOPHTHALEIN SODIUM | 22849615 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | cyclophosphamide | CYCLOPHOSPHAMIDE | 22188361,29938344,19448608,26222310 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | busulfan | BUSULFAN | 24192117 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | cisplatin | CISPLATIN | 22188361 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | doxorubicin | DOXORUBICIN | 29938344,24215845,19448608 | |
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | ETHACRYNIC ACID | 11092982 | ||
2938 | GSTA1 | ENZYME, DRUGGABLE GENOME | PHENOBARBITAL | PHENOBARBITAL | 16608922 |
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