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Gene: FKBP1A |
Gene summary for FKBP1A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FKBP1A | Gene ID | 2280 |
Gene name | FKBP prolyl isomerase 1A | |
Gene Alias | FKBP-12 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | P62942 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2280 | FKBP1A | GSM4909280 | Human | Breast | Precancer | 2.88e-04 | -5.53e-01 | 0.0305 |
2280 | FKBP1A | GSM4909287 | Human | Breast | IDC | 2.16e-02 | -2.88e-01 | 0.2057 |
2280 | FKBP1A | GSM4909294 | Human | Breast | IDC | 7.64e-08 | -1.70e-01 | 0.2022 |
2280 | FKBP1A | GSM4909296 | Human | Breast | IDC | 1.09e-10 | -3.15e-01 | 0.1524 |
2280 | FKBP1A | GSM4909297 | Human | Breast | IDC | 1.65e-22 | -2.53e-01 | 0.1517 |
2280 | FKBP1A | GSM4909301 | Human | Breast | IDC | 6.99e-09 | -3.59e-01 | 0.1577 |
2280 | FKBP1A | GSM4909304 | Human | Breast | IDC | 2.97e-16 | -5.19e-01 | 0.1636 |
2280 | FKBP1A | GSM4909308 | Human | Breast | IDC | 5.52e-13 | 4.58e-01 | 0.158 |
2280 | FKBP1A | GSM4909311 | Human | Breast | IDC | 5.12e-40 | -3.15e-01 | 0.1534 |
2280 | FKBP1A | GSM4909312 | Human | Breast | IDC | 1.77e-40 | 5.33e-01 | 0.1552 |
2280 | FKBP1A | GSM4909316 | Human | Breast | IDC | 1.71e-04 | 1.73e-02 | 0.21 |
2280 | FKBP1A | GSM4909318 | Human | Breast | IDC | 9.20e-04 | 3.14e-01 | 0.2031 |
2280 | FKBP1A | GSM4909319 | Human | Breast | IDC | 1.48e-57 | -4.19e-01 | 0.1563 |
2280 | FKBP1A | GSM4909320 | Human | Breast | IDC | 1.82e-17 | -7.62e-01 | 0.1575 |
2280 | FKBP1A | GSM4909321 | Human | Breast | IDC | 1.89e-22 | -3.10e-01 | 0.1559 |
2280 | FKBP1A | brca1 | Human | Breast | Precancer | 1.96e-15 | 4.85e-01 | -0.0338 |
2280 | FKBP1A | brca2 | Human | Breast | Precancer | 1.87e-02 | 2.21e-01 | -0.024 |
2280 | FKBP1A | M1 | Human | Breast | IDC | 6.06e-08 | -4.71e-01 | 0.1577 |
2280 | FKBP1A | M2 | Human | Breast | IDC | 1.89e-09 | 4.08e-01 | 0.21 |
2280 | FKBP1A | NCCBC14 | Human | Breast | DCIS | 1.60e-15 | -4.06e-01 | 0.2021 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:00071795 | Cervix | CC | transforming growth factor beta receptor signaling pathway | 38/2311 | 198/18723 | 3.62e-03 | 2.31e-02 | 38 |
GO:00313983 | Cervix | CC | positive regulation of protein ubiquitination | 25/2311 | 119/18723 | 5.09e-03 | 3.01e-02 | 25 |
GO:19033224 | Cervix | CC | positive regulation of protein modification by small protein conjugation or removal | 28/2311 | 138/18723 | 5.26e-03 | 3.08e-02 | 28 |
GO:00353087 | Cervix | CC | negative regulation of protein dephosphorylation | 10/2311 | 34/18723 | 6.40e-03 | 3.58e-02 | 10 |
GO:19900006 | Cervix | CC | amyloid fibril formation | 10/2311 | 34/18723 | 6.40e-03 | 3.58e-02 | 10 |
GO:0051279 | Cervix | CC | regulation of release of sequestered calcium ion into cytosol | 18/2311 | 79/18723 | 6.82e-03 | 3.74e-02 | 18 |
GO:0042987 | Cervix | CC | amyloid precursor protein catabolic process | 16/2311 | 68/18723 | 7.57e-03 | 4.04e-02 | 16 |
GO:003139615 | Cervix | HSIL_HPV | regulation of protein ubiquitination | 33/737 | 210/18723 | 1.02e-11 | 6.81e-09 | 33 |
GO:190332015 | Cervix | HSIL_HPV | regulation of protein modification by small protein conjugation or removal | 34/737 | 242/18723 | 1.16e-10 | 4.31e-08 | 34 |
GO:004211013 | Cervix | HSIL_HPV | T cell activation | 48/737 | 487/18723 | 5.12e-09 | 7.61e-07 | 48 |
GO:005134614 | Cervix | HSIL_HPV | negative regulation of hydrolase activity | 37/737 | 379/18723 | 3.81e-07 | 2.06e-05 | 37 |
GO:004593615 | Cervix | HSIL_HPV | negative regulation of phosphate metabolic process | 36/737 | 441/18723 | 3.12e-05 | 8.94e-04 | 36 |
GO:001056315 | Cervix | HSIL_HPV | negative regulation of phosphorus metabolic process | 36/737 | 442/18723 | 3.27e-05 | 9.16e-04 | 36 |
GO:000645814 | Cervix | HSIL_HPV | 'de novo' protein folding | 9/737 | 43/18723 | 3.66e-05 | 9.96e-04 | 9 |
GO:006107714 | Cervix | HSIL_HPV | chaperone-mediated protein folding | 11/737 | 67/18723 | 5.61e-05 | 1.37e-03 | 11 |
GO:000717913 | Cervix | HSIL_HPV | transforming growth factor beta receptor signaling pathway | 20/737 | 198/18723 | 1.12e-04 | 2.33e-03 | 20 |
GO:004202614 | Cervix | HSIL_HPV | protein refolding | 6/737 | 23/18723 | 2.07e-04 | 3.72e-03 | 6 |
GO:000645714 | Cervix | HSIL_HPV | protein folding | 20/737 | 212/18723 | 2.81e-04 | 4.69e-03 | 20 |
GO:199000013 | Cervix | HSIL_HPV | amyloid fibril formation | 7/737 | 34/18723 | 3.02e-04 | 4.94e-03 | 7 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FKBP1A | SNV | Missense_Mutation | novel | c.206N>G | p.Val69Gly | p.V69G | P62942 | protein_coding | deleterious(0) | possibly_damaging(0.747) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FKBP1A | SNV | Missense_Mutation | c.298N>C | p.Phe100Leu | p.F100L | P62942 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FKBP1A | SNV | Missense_Mutation | c.116N>A | p.Ser39Tyr | p.S39Y | P62942 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FKBP1A | SNV | Missense_Mutation | c.116N>G | p.Ser39Cys | p.S39C | P62942 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-CL-5917-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FKBP1A | SNV | Missense_Mutation | c.173N>A | p.Arg58Gln | p.R58Q | P62942 | protein_coding | tolerated(0.12) | benign(0.309) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
FKBP1A | SNV | Missense_Mutation | novel | c.253G>A | p.Ala85Thr | p.A85T | P62942 | protein_coding | deleterious(0.04) | benign(0.009) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FKBP1A | SNV | Missense_Mutation | novel | c.240T>G | p.Asp80Glu | p.D80E | P62942 | protein_coding | tolerated(0.16) | benign(0.029) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FKBP1A | SNV | Missense_Mutation | novel | c.263N>G | p.His88Arg | p.H88R | P62942 | protein_coding | tolerated(0.22) | probably_damaging(0.981) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FKBP1A | SNV | Missense_Mutation | c.208N>T | p.Gly70Cys | p.G70C | P62942 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
FKBP1A | SNV | Missense_Mutation | rs760096309 | c.121N>T | p.Arg41Trp | p.R41W | P62942 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | inhibitor | CHEMBL3545142 | OLOCROLIMUS | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | SCY-641 | RUCLOSPORIN | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | AP1903 | RIMIDUCID | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | Rapamycin | SIROLIMUS | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | SIROLIMUS | SIROLIMUS | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | inhibitor | CHEMBL413 | SIROLIMUS | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | TACROLIMUS | TACROLIMUS | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | AZD-8055 | AZD-8055 | 23375793 | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | inhibitor | 178102653 | SIROLIMUS | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | EVEROLIMUS | EVEROLIMUS | 24836070 |
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