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Gene: FABP1 |
Gene summary for FABP1 |
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Gene information | Species | Human | Gene symbol | FABP1 | Gene ID | 2168 |
Gene name | fatty acid binding protein 1 | |
Gene Alias | FABPL | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P07148 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2168 | FABP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.25e-09 | -4.78e-01 | 0.0155 |
2168 | FABP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.86e-37 | 3.98e+00 | -0.1808 |
2168 | FABP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.14e-21 | 2.47e+00 | -0.0811 |
2168 | FABP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.22e-04 | 1.81e+00 | -0.1088 |
2168 | FABP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.27e-55 | 3.81e+00 | -0.1954 |
2168 | FABP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.06e-05 | 3.75e+00 | -0.2602 |
2168 | FABP1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.52e-18 | 4.61e+00 | -0.2196 |
2168 | FABP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.58e-35 | 3.47e+00 | -0.1207 |
2168 | FABP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.74e-29 | 4.07e+00 | -0.1526 |
2168 | FABP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.17e-44 | 3.71e+00 | -0.1464 |
2168 | FABP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.52e-18 | 2.50e+00 | -0.1001 |
2168 | FABP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.59e-23 | 3.26e+00 | -0.059 |
2168 | FABP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.46e-11 | 3.53e+00 | -0.1706 |
2168 | FABP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.36e-24 | 4.06e+00 | -0.2061 |
2168 | FABP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.29e-15 | 4.38e+00 | -0.1462 |
2168 | FABP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.76e-04 | 1.60e+00 | -0.0842 |
2168 | FABP1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.25e-06 | 1.29e+00 | -0.00410000000000005 |
2168 | FABP1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.73e-11 | 1.69e+00 | -0.0179 |
2168 | FABP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.32e-10 | -5.56e-01 | 0.096 |
2168 | FABP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.29e-06 | 1.31e+00 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00090623 | Colorectum | FAP | fatty acid catabolic process | 31/2622 | 100/18723 | 9.77e-06 | 2.85e-04 | 31 |
GO:00003024 | Colorectum | FAP | response to reactive oxygen species | 55/2622 | 222/18723 | 1.25e-05 | 3.42e-04 | 55 |
GO:00704823 | Colorectum | FAP | response to oxygen levels | 77/2622 | 347/18723 | 2.08e-05 | 5.05e-04 | 77 |
GO:00302583 | Colorectum | FAP | lipid modification | 52/2622 | 212/18723 | 2.84e-05 | 6.49e-04 | 52 |
GO:00620122 | Colorectum | FAP | regulation of small molecule metabolic process | 74/2622 | 334/18723 | 3.15e-05 | 7.13e-04 | 74 |
GO:00714533 | Colorectum | FAP | cellular response to oxygen levels | 45/2622 | 177/18723 | 3.77e-05 | 8.13e-04 | 45 |
GO:00066353 | Colorectum | FAP | fatty acid beta-oxidation | 24/2622 | 74/18723 | 4.23e-05 | 8.91e-04 | 24 |
GO:00193953 | Colorectum | FAP | fatty acid oxidation | 30/2622 | 103/18723 | 5.09e-05 | 1.03e-03 | 30 |
GO:00016663 | Colorectum | FAP | response to hypoxia | 68/2622 | 307/18723 | 6.53e-05 | 1.25e-03 | 68 |
GO:00362932 | Colorectum | FAP | response to decreased oxygen levels | 70/2622 | 322/18723 | 9.49e-05 | 1.61e-03 | 70 |
GO:00344402 | Colorectum | FAP | lipid oxidation | 30/2622 | 108/18723 | 1.32e-04 | 2.12e-03 | 30 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
GO:00723293 | Colorectum | FAP | monocarboxylic acid catabolic process | 32/2622 | 122/18723 | 2.57e-04 | 3.53e-03 | 32 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00442422 | Colorectum | FAP | cellular lipid catabolic process | 49/2622 | 214/18723 | 2.87e-04 | 3.77e-03 | 49 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:0036294 | Colorectum | FAP | cellular response to decreased oxygen levels | 39/2622 | 161/18723 | 3.52e-04 | 4.47e-03 | 39 |
GO:0071456 | Colorectum | FAP | cellular response to hypoxia | 37/2622 | 151/18723 | 3.88e-04 | 4.75e-03 | 37 |
GO:00425424 | Colorectum | FAP | response to hydrogen peroxide | 36/2622 | 146/18723 | 4.06e-04 | 4.90e-03 | 36 |
GO:00432814 | Colorectum | FAP | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 46/2622 | 209/18723 | 1.06e-03 | 1.03e-02 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04936 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0332021 | Liver | Cirrhotic | PPAR signaling pathway | 32/2530 | 75/8465 | 1.24e-02 | 3.92e-02 | 2.42e-02 | 32 |
hsa049361 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0332031 | Liver | Cirrhotic | PPAR signaling pathway | 32/2530 | 75/8465 | 1.24e-02 | 3.92e-02 | 2.42e-02 | 32 |
hsa049362 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa033204 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa049363 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa033205 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa04975 | Stomach | GC | Fat digestion and absorption | 14/708 | 43/8465 | 5.71e-06 | 8.30e-05 | 5.84e-05 | 14 |
hsa03320 | Stomach | GC | PPAR signaling pathway | 18/708 | 75/8465 | 3.26e-05 | 4.01e-04 | 2.82e-04 | 18 |
hsa049751 | Stomach | GC | Fat digestion and absorption | 14/708 | 43/8465 | 5.71e-06 | 8.30e-05 | 5.84e-05 | 14 |
hsa033201 | Stomach | GC | PPAR signaling pathway | 18/708 | 75/8465 | 3.26e-05 | 4.01e-04 | 2.82e-04 | 18 |
hsa049752 | Stomach | SIM | Fat digestion and absorption | 12/465 | 43/8465 | 2.11e-06 | 3.05e-05 | 2.45e-05 | 12 |
hsa033202 | Stomach | SIM | PPAR signaling pathway | 15/465 | 75/8465 | 1.08e-05 | 1.42e-04 | 1.14e-04 | 15 |
hsa049753 | Stomach | SIM | Fat digestion and absorption | 12/465 | 43/8465 | 2.11e-06 | 3.05e-05 | 2.45e-05 | 12 |
hsa033203 | Stomach | SIM | PPAR signaling pathway | 15/465 | 75/8465 | 1.08e-05 | 1.42e-04 | 1.14e-04 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FABP1 | SNV | Missense_Mutation | c.227N>A | p.Gly76Glu | p.G76E | P07148 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
FABP1 | SNV | Missense_Mutation | novel | c.268N>C | p.Lys90Gln | p.K90Q | P07148 | protein_coding | deleterious(0) | possibly_damaging(0.561) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FABP1 | SNV | Missense_Mutation | novel | c.381N>G | p.Ile127Met | p.I127M | P07148 | protein_coding | tolerated(0.08) | benign(0.205) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FABP1 | SNV | Missense_Mutation | novel | c.271N>A | p.Leu91Met | p.L91M | P07148 | protein_coding | deleterious(0.04) | possibly_damaging(0.736) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FABP1 | SNV | Missense_Mutation | novel | c.172N>A | p.Val58Met | p.V58M | P07148 | protein_coding | deleterious(0.02) | possibly_damaging(0.794) | TCGA-AJ-A3IA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FABP1 | SNV | Missense_Mutation | c.70N>A | p.Leu24Met | p.L24M | P07148 | protein_coding | tolerated(0.06) | benign(0.154) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
FABP1 | SNV | Missense_Mutation | novel | c.371N>A | p.Ser124Asn | p.S124N | P07148 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FABP1 | SNV | Missense_Mutation | rs772030208 | c.319G>A | p.Asp107Asn | p.D107N | P07148 | protein_coding | tolerated(0.18) | benign(0.062) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FABP1 | SNV | Missense_Mutation | c.293N>C | p.Ile98Thr | p.I98T | P07148 | protein_coding | deleterious(0.03) | possibly_damaging(0.79) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FABP1 | SNV | Missense_Mutation | novel | c.7T>G | p.Phe3Val | p.F3V | P07148 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2168 | FABP1 | DRUGGABLE GENOME | FENOFIBRIC ACID | |||
2168 | FABP1 | DRUGGABLE GENOME | fenofibrate | FENOFIBRATE | 15249972 | |
2168 | FABP1 | DRUGGABLE GENOME | DEXAMETHASONE | DEXAMETHASONE | 15324484,15532708 | |
2168 | FABP1 | DRUGGABLE GENOME | CLOFIBRATE | CLOFIBRATE | 2328261 |
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